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2C9A
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BU of 2c9a by Molmil
Crystal structure of the MAM-Ig module of receptor protein tyrosine phosphatase mu
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, ...
Authors:Aricescu, A.R, Hon, W.C, Siebold, C, Lu, W, Van Der Merwe, P.A, Jones, E.Y.
Deposit date:2005-12-09
Release date:2006-01-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Analysis of Receptor Protein Tyrosine Phosphatase Mu-Mediated Cell Adhesion.
Embo J., 25, 2006
2V5Y
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BU of 2v5y by Molmil
Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION
Authors:Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y.
Deposit date:2007-07-11
Release date:2007-09-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism.
Science, 317, 2007
5KC6
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BU of 5kc6 by Molmil
Crystal structure of Cbln1 (Val55-Gly58 deletion mutant)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1
Authors:Elegheert, J, Clay, J.E, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
1JLN
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BU of 1jln by Molmil
Crystal structure of the catalytic domain of protein tyrosine phosphatase PTP-SL/BR7
Descriptor: Protein Tyrosine Phosphatase, receptor type, R
Authors:Szedlacsek, S.E, Aricescu, A.R, Fulga, T.A, Renault, L, Scheidig, A.J.
Deposit date:2001-07-16
Release date:2001-08-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
J.Mol.Biol., 311, 2001
7A4M
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BU of 7a4m by Molmil
Cryo-EM structure of mouse heavy-chain apoferritin at 1.22 A
Descriptor: FE (III) ION, Ferritin heavy chain, ZINC ION
Authors:Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W.
Deposit date:2020-08-20
Release date:2020-10-28
Last modified:2023-06-21
Method:ELECTRON MICROSCOPY (1.22 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
7A5V
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BU of 7a5v by Molmil
CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W.
Deposit date:2020-08-22
Release date:2020-11-18
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (1.7 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
6QD6
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BU of 6qd6 by Molmil
Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207
Descriptor: CHLORIDE ION, Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207
Authors:Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkonig, A, Zogg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
Deposit date:2018-12-31
Release date:2019-12-18
Last modified:2021-01-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Nat.Methods, 18, 2021
6QFA
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BU of 6qfa by Molmil
CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ...
Authors:Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
Deposit date:2019-01-09
Release date:2021-08-04
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
2CME
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BU of 2cme by Molmil
The crystal structure of SARS coronavirus ORF-9b protein
Descriptor: DECANE, HYPOTHETICAL PROTEIN 5
Authors:Meier, C, Aricescu, A.R, Assenberg, R, Aplin, R.T, Gilbert, R.J.C, Grimes, J.M, Stuart, D.I.
Deposit date:2006-05-06
Release date:2006-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of Orf-9B, a Lipid Binding Protein from the Sars Coronavirus.
Structure, 14, 2006
3SUA
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BU of 3sua by Molmil
Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.39 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3SU8
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BU of 3su8 by Molmil
Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
6YPE
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BU of 6ype by Molmil
Crystal structure of the human neuronal pentraxin 1 (NP1) pentraxin (PTX) domain.
Descriptor: CACODYLATE ION, CALCIUM ION, Neuronal pentraxin-1
Authors:Elegheert, J, Clayton, A.J, Aricescu, A.R.
Deposit date:2020-04-15
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Science, 369, 2020
5KCA
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BU of 5kca by Molmil
Crystal structure of the Cbln1 C1q domain trimer in complex with the amino-terminal domain (ATD) of iGluR Delta-2 (GluD2)
Descriptor: CALCIUM ION, Cerebellin-1,Cerebellin-1,Cerebellin-1,Glutamate receptor ionotropic, delta-2
Authors:Elegheert, J, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
5KC8
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BU of 5kc8 by Molmil
Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-2 (GluD2)
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Glutamate receptor ionotropic, ...
Authors:Elegheert, J, Clay, J.E, Siebold, C, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
5KC5
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BU of 5kc5 by Molmil
Crystal structure of the Cbln1 C1q domain trimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1
Authors:Elegheert, J, Clay, J.E, Siebold, C, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
5KC9
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BU of 5kc9 by Molmil
Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-1 (GluD1)
Descriptor: 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Elegheert, J, Clay, J.E, Siebold, C, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
5KC7
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BU of 5kc7 by Molmil
Crystal structure of Cbln1 (Val55-Gly58 deletion mutant)
Descriptor: Cerebellin-1
Authors:Elegheert, J, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (7.035 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016
4PBV
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BU of 4pbv by Molmil
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NT-3 growth factor receptor, Protein-tyrosine phosphatase CRYPalpha1 isoform, ...
Authors:Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R.
Deposit date:2014-04-14
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis.
Nat Commun, 5, 2014
4PBX
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BU of 4pbx by Molmil
Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase S
Authors:Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R.
Deposit date:2014-04-14
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis.
Nat Commun, 5, 2014
4PBW
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BU of 4pbw by Molmil
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NT-3 growth factor receptor, Protein-tyrosine phosphatase CRYPalpha1 isoform
Authors:Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R.
Deposit date:2014-04-14
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis.
Nat Commun, 5, 2014
7NDG
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BU of 7ndg by Molmil
Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ...
Authors:Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
Deposit date:2021-02-01
Release date:2021-03-31
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (5.98 Å)
Cite:Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
6HUK
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BU of 6huk by Molmil
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUG
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BU of 6hug by Molmil
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUO
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BU of 6huo by Molmil
CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-09
Release date:2019-01-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUJ
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BU of 6huj by Molmil
CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019

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