Author results

3NEW
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P38-ALPHA COMPLEXED WITH COMPOUND 10
分子名称:Mitogen-activated protein kinase 14, 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one
著者Goedken, E.R., Comess, K.M., Sun, C., Argiriadi, M., Jia, Y., Quinn, C.M., Banach, D.L., Marcotte, D., Borhani, D.
登録日2010-06-09
公開日2010-12-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases.
Acs Chem.Biol., 6, 2011
4Q9S
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CRYSTAL STRUCTURE OF HUMAN FOCAL ADHESION KINASE (FAK) BOUND TO COMPOUND1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)
分子名称:Focal adhesion kinase 1, 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one
著者Argiriadi, M.A., George, D.M.
登録日2014-05-01
公開日2014-07-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit.
J.Med.Chem., 58, 2015
4Q9Z
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HUMAN PROTEIN KINASE C THETA IN COMPLEX WITH COMPOUND35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)
分子名称:HUMAN PROTEIN KINASE C THETA, (1R)-9-(azetidin-3-ylamino)-1,8-dimethyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, SODIUM ION
著者Argiriadi, M.A., George, D.M.
登録日2014-05-02
公開日2014-07-02
最終更新日2015-01-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit.
J.Med.Chem., 58, 2015
5T68
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CRYSTAL STRUCTURE OF SYK CATALYTIC DOMAIN IN COMPLEX WITH A FURO[3,2-D]PYRIMIDINE
分子名称:Tyrosine-protein kinase SYK, N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine
著者Argiriadi, M.A., Hoemann, M., Wilson, N., Banach, D., Burchat, A., Calderwood, D., Clapham, B., Cox, P., Duignan, D.B., Konopacki, D., Somal, G., Vasudevan, A.
登録日2016-09-01
公開日2016-10-26
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.
Bioorg. Med. Chem. Lett., 26, 2016
3O2M
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CRYSTAL STRUCTURE OF JNK1-ALPHA1 ISOFORM COMPLEX WITH A BIARYL TETRAZOL (A-82118)
分子名称:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, JIP1, ...
著者Abad-Zapatero, C.
登録日2010-07-22
公開日2011-01-12
最終更新日2011-09-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Acs Chem.Biol., 6, 2011