Author results

4QBY
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YCP IN COMPLEX WITH BOC-ALA-ALA-ALA-CHO
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Arciniega, M., Beck, P., Lange, O., Groll, M., Huber, R.
Deposit date:2014-05-09
Release date:2014-06-18
Last modified:2014-07-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding.
Proc.Natl.Acad.Sci.USA, 111, 2014
3SHJ
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PROTEASOME IN COMPLEX WITH HYDROXYUREA DERIVATIVE HU10
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Gallastegui, N., Beck, P., Arciniega, M., Hillebrand, S., Huber, R., Groll, M.
Deposit date:2011-06-16
Release date:2011-12-07
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Hydroxyureas as noncovalent proteasome inhibitors.
Angew.Chem.Int.Ed.Engl., 51, 2012
3V3V
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF QUERCETAGETIN, A NATURAL JNK1 INHIBITOR
Descriptor:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ...
Authors:Baek, S., Kang, N.J., Popowicz, G.M., Arciniega, M., Jung, S.K., Byun, S., Song, N.R., Heo, Y.S., Kim, B.Y., Lee, H.J., Holak, T.A., Augustin, M., Bode, A.M., Huber, R., Dong, Z., Lee, K.W.
Deposit date:2011-12-14
Release date:2012-12-05
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
J.Mol.Biol., 425, 2013
5JXG
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXH
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STRUCTURE THE PROPROTEIN CONVERTASE FURIN IN COMPLEX WITH META-GUANIDINOMETHYL-PHAC-RVR-AMBA AT 2.0 ANGSTROM RESOLUTION.
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXI
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN IN PRESENCE OF EDTA.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXJ
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STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN COMPLEXED TO META-GUANIDINOMETHYL-PHAC-RVR-AMBA IN PRESENCE OF EDTA
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
4MDN
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STRUCTURE OF A NOVEL SUBMICROMOLAR MDM2 INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, SULFATE ION
Authors:Bista, M., Popowicz, G., Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
4MDQ
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STRUCTURE OF A NOVEL SUBMICROMOLAR MDM2 INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide
Authors:Bista, M., Popowicz, G., Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
5F5W
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CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF GLYCYL TRNA SYNTHETASE (GLYRS) FROM AQUIFEX AEOLICUS IN COMPLEX WITH AN ANALOG OF GLYCYL ADENYLATE (GLY-SA)
Descriptor:Glycine--tRNA ligase alpha subunit, 5'-O-(glycylsulfamoyl)adenosine
Authors:Valencia-Sanchez, M.I., Torres-Larios, A.
Deposit date:2015-12-04
Release date:2016-05-11
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.
J.Biol.Chem., 291, 2016
6EOO
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DPP8 - APO, SPACE GROUP 20
Descriptor:Dipeptidyl peptidase 8
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EOP
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DPP8 - SLRFLYEG, SPACE GROUP 20
Descriptor:Dipeptidyl peptidase 8, SER-LEU-ARG-PHE-LEU-TYR-GLU-GLY, CITRATE ANION, ...
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EOQ
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DPP9 - APO
Descriptor:Dipeptidyl peptidase 9
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EOR
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DPP9 - 1G244
Descriptor:Dipeptidyl peptidase 9, (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EOS
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DPP8 - APO, SPACE GROUP 19
Descriptor:Dipeptidyl peptidase 8
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EOT
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DPP8 - SLRFLYEG, SPACE GROUP 19
Descriptor:Dipeptidyl peptidase 8, SER-LEU-ARG-PHE-LEU-TYR-GLU-GLY
Authors:Ross, B.R., Huber, R.
Deposit date:2017-10-10
Release date:2018-02-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MAX
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CRYSTAL STRUCTURE OF RIBONUCLEASE P PROTEIN FROM THERMOTOGA MARITIMA IN COMPLEX WITH PURPURIN
Descriptor:Ribonuclease P protein component, SULFATE ION, Purpurin
Authors:Torres-Larios, A., Madrigal-Carrillo, E.A.
Deposit date:2018-08-28
Release date:2019-04-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor.
Nucleic Acids Res., 2019