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1XFB
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BU of 1xfb by Molmil
Human Brain Fructose 1,6-(bis)phosphate Aldolase (C isozyme)
Descriptor: Aldolase C
Authors:Arakaki, T.L, Pezza, J.A, Cronin, M.A, Hopkins, C.E, Zimmer, D.B, Tolan, D.R, Allen, K.N.
Deposit date:2004-09-14
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function
Protein Sci., 13, 2004
2HQJ
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BU of 2hqj by Molmil
Cyclophilin from Leishmania major
Descriptor: PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2006-07-18
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cyclophilin from Leishmania major
To be Published
2B4G
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BU of 2b4g by Molmil
dihydroorotate dehydrogenase
Descriptor: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-23
Release date:2005-10-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
3C61
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BU of 3c61 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, AZIDE ION, CHLORIDE ION, ...
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-02-01
Release date:2008-02-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dihydroorotate dehydrogenase from Leishmania donovani.
To be Published
3CH7
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BU of 3ch7 by Molmil
Crystal structure of 6-phosphogluconolactonase from Leishmania braziliensis
Descriptor: 6-phosphogluconolactonase
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-03-07
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:6-phosphogluconolactonase from Leishmania braziliensis.
to be published
3E15
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BU of 3e15 by Molmil
6-phosphogluconolactonase from Plasmodium vivax
Descriptor: AZIDE ION, CHLORIDE ION, Glucose-6-phosphate 1-dehydrogenase, ...
Authors:Arakaki, T.L, Merritt, E.A.
Deposit date:2008-08-01
Release date:2008-08-19
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:6-phosphogluconolactonase from Plasmodium vivax
To be Published
3E3P
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BU of 3e3p by Molmil
Glycogen synthase kinase from Leishmania major
Descriptor: Protein kinase, putative Glycogen synthase kinase
Authors:Arakaki, T.L, Merritt, E.A.
Deposit date:2008-08-07
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Glycogen synthase kinase from Leishmania major
To be Published
3FOC
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BU of 3foc by Molmil
Tryptophanyl-tRNA synthetase from Giardia lamblia
Descriptor: GLYCEROL, SULFATE ION, Tryptophanyl-tRNA synthetase
Authors:Arakaki, T.L, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-12-29
Release date:2009-01-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.
J.Struct.Biol., 171, 2010
3MEQ
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BU of 3meq by Molmil
Crystal structure of alcohol dehydrogenase from Brucella melitensis
Descriptor: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Alcohol dehydrogenase, ...
Authors:Arakaki, T.L, Staker, B.L, Gardberg, A, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of alcohol dehydrogenase from Brucella melitensis
To be Published
3HRK
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BU of 3hrk by Molmil
Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidyl-adenylate complex)
Descriptor: CHLORIDE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE, Histidyl-tRNA synthetase
Authors:Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-06-09
Release date:2009-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
3HRI
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BU of 3hri by Molmil
Histidyl-tRNA synthetase (apo) from Trypanosoma brucei
Descriptor: Histidyl-tRNA synthetase
Authors:Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-06-09
Release date:2009-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
3BWC
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BU of 3bwc by Molmil
Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution
Descriptor: BETA-MERCAPTOETHANOL, S-ADENOSYLMETHIONINE, Spermidine synthase
Authors:Bosch, J, Arakaki, T.L, Le Trong, I, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-09
Release date:2008-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
6OOY
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BU of 6ooy by Molmil
Asymmetric hTNF-alpha
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Tumor necrosis factor, {1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}methanol
Authors:Arakaki, T.L, Edwards, T.E, Ceska, T.
Deposit date:2019-04-23
Release date:2019-12-25
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
2GZQ
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BU of 2gzq by Molmil
Phosphatidylethanolamine-binding protein from Plasmodium vivax
Descriptor: Phosphatidylethanolamine-binding protein
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2006-05-11
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix
Acta Crystallogr.,Sect.F, 63, 2007
6OP0
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BU of 6op0 by Molmil
Asymmetric hTNF-alpha
Descriptor: (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, Tumor necrosis factor
Authors:Arakaki, T.L, Edwards, T.E, Fairman, J.W, Davies, D.R, Foley, A, Ceska, T.
Deposit date:2019-04-23
Release date:2019-12-25
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
6OOZ
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BU of 6ooz by Molmil
Asymmetric hTNF-alpha
Descriptor: (S)-{1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, CHLORIDE ION, Tumor necrosis factor
Authors:Arakaki, T.L, Edwards, T.E, Fox III, D, Lecomte, F, Ceska, T.
Deposit date:2019-04-23
Release date:2019-12-25
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
2A0M
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BU of 2a0m by Molmil
Arginase superfamily protein from Trypanosoma cruzi
Descriptor: ARGINASE SUPERFAMILY PROTEIN, CHLORIDE ION
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-16
Release date:2005-07-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structural genomics of pathogenic protozoa: an overview.
Methods Mol.Biol., 426, 2008
2AR1
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BU of 2ar1 by Molmil
Structure of Hypothetical protein from Leishmania major
Descriptor: GLYCEROL, hypothetical protein
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-08-18
Release date:2005-08-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Acta Crystallogr.,Sect.F, 62, 2006
3I3F
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BU of 3i3f by Molmil
Hypothetical protein from Giardia lamblia GL50803_14299
Descriptor: BUTANOIC ACID, Hypothetical protein, PENTANOIC ACID
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-06-30
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Hypothetical protein from Giardia lamblia GL50803_14299
To be Published
7KP7
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BU of 7kp7 by Molmil
asymmetric mTNF-alpha hTNFR1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ...
Authors:Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
7KP9
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BU of 7kp9 by Molmil
asymmetric hTNF-alpha
Descriptor: 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor
Authors:Arakaki, T.L, Abendroth, J, Fairman, J.W, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
7KP8
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BU of 7kp8 by Molmil
asymmetric mTNF-alpha hTNFR1 complex
Descriptor: 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A
Authors:Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
3CSS
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BU of 3css by Molmil
Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis
Descriptor: 6-phosphogluconolactonase, PHOSPHATE ION
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-04-10
Release date:2008-04-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.
Acta Crystallogr.,Sect.D, 62, 2006
3U0B
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BU of 3u0b by Molmil
Crystal structure of an oxidoreductase from Mycobacterium smegmatis
Descriptor: Oxidoreductase, short chain dehydrogenase/reductase family protein, SODIUM ION
Authors:Arakaki, T.L, Staker, B.L, Clifton, M.C, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3U0A
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BU of 3u0a by Molmil
Crystal structure of an Acyl-CoA thioesterase II TesB2 from Mycobacterium marinum
Descriptor: Acyl-CoA thioesterase II TesB2, GLYCEROL, SODIUM ION, ...
Authors:Arakaki, T.L, Staker, B.L, Clifton, M.C, Sankaran, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015

 

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