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2LAZ
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BU of 2laz by Molmil
Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide
Descriptor: E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAW
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BU of 2law by Molmil
Structure of the second WW domain from human YAP in complex with a human Smad1 derived peptide
Descriptor: Mothers against decapentaplegic homolog 1, Yorkie homolog
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAX
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BU of 2lax by Molmil
Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.
Descriptor: Mothers against decapentaplegic homolog 1, Yorkie homolog
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB0
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BU of 2lb0 by Molmil
Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide
Descriptor: E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LTV
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BU of 2ltv by Molmil
YAP WW2 in complex with a Smad7 derived peptide
Descriptor: Smad7 derived peptide, Yorkie homolog
Authors:Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LB3
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BU of 2lb3 by Molmil
Structure of the WW domain of PIN1 in complex with a human phosphorylated Smad3 derived peptide
Descriptor: Mothers against decapentaplegic homolog 2, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB2
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BU of 2lb2 by Molmil
Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAY
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BU of 2lay by Molmil
Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
Descriptor: Mothers against decapentaplegic homolog 1, Yorkie homolog
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB1
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BU of 2lb1 by Molmil
Structure of the second domain of human Smurf1 in complex with a human Smad1 derived peptide
Descriptor: E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAJ
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BU of 2laj by Molmil
Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-16
Release date:2011-07-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LTW
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BU of 2ltw by Molmil
YAP WW1 in complex with a Smad7 derived peptide
Descriptor: Smad7 derived peptide, Yorkie homolog
Authors:Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTX
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BU of 2ltx by Molmil
Smurf1 WW2 domain in complex with a Smad7 derived peptide
Descriptor: E3 ubiquitin-protein ligase SMURF1, Smad7 derived peptide
Authors:Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTY
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BU of 2lty by Molmil
NEDD4L WW2 domain in complex with a Smad7 derived peptide
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Smad7 derived peptide
Authors:Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTZ
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BU of 2ltz by Molmil
Smurf2 WW3 domain in complex with a Smad7 derived peptide
Descriptor: E3 ubiquitin-protein ligase SMURF2, Smad7 derived peptide
Authors:Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
4R9P
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BU of 4r9p by Molmil
An Expansion to the Smad MH2-family: The structure of the N-MH2 expanded domain
Descriptor: RE28239p
Authors:Beich-Frandsen, M, Aragon, E, Llimargas, M, Benach, J, Riera, A, Macias, M.J.
Deposit date:2014-09-06
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.592 Å)
Cite:Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2
Acta Crystallogr.,Sect.D, 71, 2015
6Z7O
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BU of 6z7o by Molmil
Crystal structure of Thioredoxin T from Drosophila melanogaster
Descriptor: Thioredoxin-T, ZINC ION
Authors:Freier, R, Aragon, E, Baginski, B, Pluta, R, Martin-Malpartida, P, Torner, C, Gonzaez, C, Macias, M.
Deposit date:2020-05-31
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins.
Iucrj, 8, 2021
2MPT
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BU of 2mpt by Molmil
WW3 domain of Nedd4L in complex with its HECT domain PY motif
Descriptor: E3 ubiquitin-protein ligase NEDD4-like
Authors:Escobedo, A, Macias, M.J, Gomes, T, Aragon, E, Martin-Malpartida, P, Ruiz, L.
Deposit date:2014-06-02
Release date:2014-10-22
Method:SOLUTION NMR
Cite:Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L.
Structure, 22, 2014
6H3R
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BU of 6h3r by Molmil
Crystal structure of Smad2 without exon -MH1 bound to the CAGAC site.
Descriptor: DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP*CP*AP*CP*TP*C)-3'), Mothers against decapentaplegic homolog, ZINC ION
Authors:Kaczmarska, Z, Marquez, J.A, Macias, M.J.
Deposit date:2018-07-19
Release date:2019-09-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-beta signaling
Genes Dev., 2020
6Y1Q
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BU of 6y1q by Molmil
Cortistatin analog with improved immunoregulatory activity
Descriptor: Analog 5, OCTANOIC ACID (CAPRYLIC ACID)
Authors:Rol, A.
Deposit date:2020-02-13
Release date:2021-01-27
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.
Nat Commun, 12, 2021
6FQP
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BU of 6fqp by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA
Descriptor: CALCIUM ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
Authors:Guca, E, Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FQQ
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BU of 6fqq by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
Authors:Guca, E, Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.25000262 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6ZMU
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BU of 6zmu by Molmil
Crystal structure of the germline-specific thioredoxin protein Deadhead (Thioredoxin-1) from Drospohila melanogaster, P43212
Descriptor: SODIUM ION, SULFATE ION, Thioredoxin-1
Authors:Baginski, B, Pluta, R, Macias, M.J.
Deposit date:2020-07-03
Release date:2020-10-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins.
Iucrj, 8, 2021
6TBZ
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BU of 6tbz by Molmil
Crystal structure of the MH1 domain of Smad5-Smad3 chimera construct bound to the GGCGC site
Descriptor: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 5, ZINC ION
Authors:Pluta, R, Macias, M.J.
Deposit date:2019-11-04
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
Comput Struct Biotechnol J, 19, 2021
6TCE
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BU of 6tce by Molmil
Crystal structure of the GGCT site-bound MH1 domain of Smad5 containing a GGGS insertion in the Loop1
Descriptor: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 5, ZINC ION
Authors:Pluta, R, Macias, M.J.
Deposit date:2019-11-05
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
Comput Struct Biotechnol J, 19, 2021
7YZ7
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BU of 7yz7 by Molmil
Crystal structure of the zebrafish FoxH1 bound to the TGTGGATT site
Descriptor: DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*GP*GP*AP*TP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*AP*TP*CP*CP*AP*CP*AP*AP*TP*CP*T)-3'), Forkhead box protein H1, ...
Authors:Pluta, R, Macias, M.J.
Deposit date:2022-02-18
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.
Nat Commun, 13, 2022

 

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