Author results

2LAJ
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THIRD WW DOMAIN OF HUMAN NEDD4L IN COMPLEX WITH DOUBLY PHOSPHORYLATED HUMAN SMAD3 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-16
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAW
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STRUCTURE OF THE SECOND WW DOMAIN FROM HUMAN YAP IN COMPLEX WITH A HUMAN SMAD1 DERIVED PEPTIDE
Descriptor:Yorkie homolog, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAX
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STRUCTURE OF FIRST WW DOMAIN OF HUMAN YAP IN COMPLEX WITH A HUMAN SMAD1 DOUBLY-PHOSPHORILATED DERIVED PEPTIDE.
Descriptor:Yorkie homolog, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAY
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STRUCTURE OF THE FIRST WW DOMAIN OF HUMAN YAP IN COMPLEX WITH A PHOSPHORYLATED HUMAN SMAD1 DERIVED PEPTIDE
Descriptor:Yorkie homolog, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LAZ
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STRUCTURE OF THE FIRST WW DOMAIN OF HUMAN SMURF1 IN COMPLEX WITH A MONO-PHOSPHORYLATED HUMAN SMAD1 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB0
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STRUCTURE OF THE FIRST WW DOMAIN OF HUMAN SMURF1 IN COMPLEX WITH A DI-PHOSPHORYLATED HUMAN SMAD1 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB1
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STRUCTURE OF THE SECOND DOMAIN OF HUMAN SMURF1 IN COMPLEX WITH A HUMAN SMAD1 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB2
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STRUCTURE OF THE SECOND DOMAIN OF HUMAN NEDD4L IN COMPLEX WITH A PHOSPHORYLATED PTPY MOTIF DERIVED FROM HUMAN SMAD3
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LB3
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STRUCTURE OF THE WW DOMAIN OF PIN1 IN COMPLEX WITH A HUMAN PHOSPHORYLATED SMAD3 DERIVED PEPTIDE
Descriptor:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Mothers against decapentaplegic homolog 2
Authors:Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
2LTV
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YAP WW2 IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
Descriptor:Yorkie homolog, Smad7 derived peptide
Authors:Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTW
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YAP WW1 IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
Descriptor:Yorkie homolog, Smad7 derived peptide
Authors:Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTX
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SMURF1 WW2 DOMAIN IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF1, Smad7 derived peptide
Authors:Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTY
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NEDD4L WW2 DOMAIN IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Smad7 derived peptide
Authors:Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2LTZ
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SMURF2 WW3 DOMAIN IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF2, Smad7 derived peptide
Authors:Macias, M.J., Aragon, E., Goerner, N., Xi, Q., Lopes, T., Gao, S., Massague, J.
Deposit date:2012-06-04
Release date:2012-11-21
Method:SOLUTION NMR
Cite:Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
2MPT
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WW3 DOMAIN OF NEDD4L IN COMPLEX WITH ITS HECT DOMAIN PY MOTIF
Descriptor:E3 ubiquitin-protein ligase NEDD4-like
Authors:Escobedo, A., Macias, M.J., Gomes, T., Aragon, E., Martin-Malpartida, P., Ruiz, L.
Deposit date:2014-06-02
Release date:2014-10-22
Method:SOLUTION NMR
Cite:Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L.
Structure, 22, 2014
4R9P
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AN EXPANSION TO THE SMAD MH2-FAMILY: THE STRUCTURE OF THE N-MH2 EXPANDED DOMAIN
Descriptor:RE28239p
Authors:Beich-Frandsen, M., Aragon, E., Llimargas, M., Benach, J., Riera, A., Macias, M.J.
Deposit date:2014-09-06
Release date:2015-04-08
Method:X-RAY DIFFRACTION (1.592 Å)
Cite:Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2
Acta Crystallogr.,Sect.D, 71, 2015
6FQP
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CRYSTAL STRUCTURE OF TALE HOMEOBOX DOMAIN TRANSCRIPTION FACTOR TGIF1 WITH ITS CONSENSUS DNA
Descriptor:DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1, CALCIUM ION
Authors:Guca, E., Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FQQ
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CRYSTAL STRUCTURE OF TALE HOMEOBOX DOMAIN TRANSCRIPTION FACTOR TGIF1 DOUBLE ALANINE MUTANT BOUND TO ITS CONSENSUS DNA
Descriptor:Homeobox protein TGIF1, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), CHLORIDE ION
Authors:Guca, E., Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3.250003 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
2K85
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P190-A RHOGAP FF1 DOMAIN
Descriptor:Glucocorticoid receptor DNA-binding factor 1
Authors:Bonet, R., Ruiz, L., Martin-Malpartida, P., Macias, M.
Deposit date:2008-09-02
Release date:2009-05-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding.
J.Mol.Biol., 389, 2009
5MEY
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CRYSTAL STRUCTURE OF SMAD4-MH1 BOUND TO THE GGCGC SITE.
Descriptor:MH1 domain of human Smad4, DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*GP*CP*AP*T)-3'), ZINC ION, ...
Authors:Kaczmarska, Z., Freier, R., Marquez, J.A., Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5MEZ
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CRYSTAL STRUCTURE OF SMAD4-MH1 BOUND TO THE GGCT SITE.
Descriptor:MH1 domain of human Smad4, DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), ZINC ION, ...
Authors:Kaczmarska, Z., Freier, R., Marquez, J.A., Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5MF0
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CRYSTAL STRUCTURE OF SMAD4-MH1 BOUND TO THE GGCCG SITE.
Descriptor:MH1 domain of human Smad4, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), ZINC ION, ...
Authors:Kaczmarska, Z., Freier, R., Marquez, J.A., Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5NM9
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CRYSTAL STRUCTURE OF THE PLACOZOA TRICHOPLAX ADHAERENS SMAD4-MH1 BOUND TO THE GGCGC SITE.
Descriptor:Mothers against decapentaplegic homolog, DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*GP*CP*AP*T)-3'), ZINC ION
Authors:Kaczmarska, Z., Freier, R., Marquez, J.A., Macias, M.J.
Deposit date:2017-04-05
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5OD6
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CRYSTAL STRUCTURE OF SMAD3-MH1 BOUND TO THE GGCGC SITE.
Descriptor:Mothers against decapentaplegic homolog 3, DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), ZINC ION
Authors:Kaczmarska, Z., Marquez, J.A., Macias, M.J.
Deposit date:2017-07-04
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5ODG
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CRYSTAL STRUCTURE OF SMAD3-MH1 BOUND TO THE GGCT SITE.
Descriptor:Mothers against decapentaplegic homolog 3, DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), ZINC ION, ...
Authors:Kaczmarska, Z., Marquez, J.A., Macias, M.J.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
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