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2V4L
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COMPLEX OF HUMAN PHOSPHOINOSITIDE 3-KINASE CATALYTIC SUBUNIT GAMMA (P110 GAMMA) WITH PIK-284
分子名称:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
著者Apsel, B., Gonzalez, B., Blair, J.A., Nazif, T.M., Feldman, M.E., Williams, R.L., Shokat, K.M., Knight, Z.A.
登録日2008-09-25
公開日2008-10-14
最終更新日2013-04-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases.
Nat.Chem.Biol., 4, 2008
3EN4
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TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP121, A MULTITARGETED KINASE INHIBITOR
分子名称:Proto-oncogene tyrosine-protein kinase Src, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Blair, J.A., Apsel, B., Knight, Z.A., Shokat, K.M.
登録日2008-09-25
公開日2008-10-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
3EN5
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TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP494, A MULTITARGETED KINASE INHIBITOR
分子名称:Proto-oncogene tyrosine-protein kinase Src, 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Blair, J.A., Apsel, B., Knight, Z.A., Shokat, K.M.
登録日2008-09-25
公開日2008-10-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
3EN6
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TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP102, A MULTITARGETED KINASE INHIBITOR
分子名称:Proto-oncogene tyrosine-protein kinase Src, 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Blair, J.A., Apsel, B., Knight, Z.A., Shokat, K.M.
登録日2008-09-25
公開日2008-10-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
3EN7
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TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH S1, A MULTITARGETED KINASE INHIBITOR
分子名称:Proto-oncogene tyrosine-protein kinase Src, 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
著者Blair, J.A., Apsel, B., Knight, Z.A., Shokat, K.M.
登録日2008-09-25
公開日2008-10-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
3ENE
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COMPLEX OF PI3K GAMMA WITH AN INHIBITOR
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Apsel, B., Blair, J.A., Gonzalez, B.Z., Nazif, T.M., Feldman, M.E., Williams, R.L., Shokat, K.M., Knight, Z.A.
登録日2008-09-25
公開日2008-10-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Nat.Chem.Biol., 4, 2008