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2H3L
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BU of 2h3l by Molmil
Crystal Structure of ERBIN PDZ
Descriptor: LAP2 protein
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2C
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BU of 2h2c by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)
Descriptor: Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2B
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BU of 2h2b by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)
Descriptor: ACETIC ACID, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3M
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BU of 2h3m by Molmil
Crystal Structure of ZO-1 PDZ1
Descriptor: SULFATE ION, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
1T6L
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BU of 1t6l by Molmil
Crystal Structure of the Human Cytomegalovirus DNA Polymerase Subunit, UL44
Descriptor: DNA polymerase processivity factor
Authors:Appleton, B.A, Loregian, A, Filman, D.J, Coen, D.M, Hogle, J.M.
Deposit date:2004-05-06
Release date:2004-08-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Cytomegalovirus DNA Polymerase Subunit UL44 Forms a C Clamp-Shaped Dimer.
Mol.Cell, 15, 2004
2QQO
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BU of 2qqo by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQN
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BU of 2qqn by Molmil
Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
Descriptor: 1,2-ETHANEDIOL, Antibody heavy chain, Antibody light chain, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQM
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BU of 2qqm by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQK
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BU of 2qqk by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQI
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BU of 2qqi by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-1
Descriptor: GLYCEROL, Neuropilin-1
Authors:Appleton, B.A, Desmarais, W, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQL
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BU of 2qql by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Neuropilin-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQJ
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BU of 2qqj by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-2
Descriptor: GLYCEROL, Neuropilin-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
1YYP
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BU of 1yyp by Molmil
Crystal structure of cytomegalovirus UL44 bound to C-terminal peptide from CMV UL54
Descriptor: 1,2-ETHANEDIOL, DNA polymerase, DNA polymerase processivity factor, ...
Authors:Appleton, B.A, Brooks, J, Loregian, A, Filman, D.J, Coen, D.M, Hogle, J.M.
Deposit date:2005-02-25
Release date:2005-12-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
J.Biol.Chem., 281, 2006
2AQ5
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BU of 2aq5 by Molmil
Crystal Structure of Murine Coronin-1
Descriptor: Coronin-1A
Authors:Appleton, B.A, Wu, P, Wiesmann, C.
Deposit date:2005-08-17
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes.
Structure, 14, 2006
2B4E
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BU of 2b4e by Molmil
Crystal Structure of Murine Coronin-1: monoclinic form
Descriptor: Coronin-1A
Authors:Appleton, B.A, Wu, P, Wiesmann, C.
Deposit date:2005-09-23
Release date:2005-12-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes
Structure, 14, 2006
5D9L
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BU of 5d9l by Molmil
Rsk2 N-terminal Kinase in Complex with bis-phenol pyrazole
Descriptor: 4,4'-(1H-pyrazole-3,4-diyl)diphenol, GLYCEROL, Ribosomal protein S6 kinase alpha-3
Authors:Appleton, B.A.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
5D9K
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BU of 5d9k by Molmil
Rsk2 N-terminal Kinase in Complex with BI-D1870
Descriptor: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, Ribosomal protein S6 kinase alpha-3
Authors:Appleton, B.A.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
6B8U
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BU of 6b8u by Molmil
Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor
Descriptor: Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide
Authors:Appleton, B.A, Murray, J, Shafer, C.M.
Deposit date:2017-10-09
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
3QTI
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BU of 3qti by Molmil
c-Met Kinase in Complex with NVP-BVU972
Descriptor: 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline, CHLORIDE ION, GLYCEROL, ...
Authors:Appleton, B.A.
Deposit date:2011-02-22
Release date:2011-07-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients.
Cancer Res., 71, 2011
5CT7
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BU of 5ct7 by Molmil
BRAF in Complex with RAF265
Descriptor: 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, Serine/threonine-protein kinase B-raf
Authors:Appleton, B.A.
Deposit date:2015-07-23
Release date:2015-09-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Acs Med.Chem.Lett., 6, 2015
7LSW
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BU of 7lsw by Molmil
Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP
Descriptor: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION
Authors:Appleton, B.A.
Deposit date:2021-02-18
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
7LT6
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BU of 7lt6 by Molmil
Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP
Descriptor: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein
Authors:Appleton, B.A.
Deposit date:2021-02-18
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
4Q2P
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BU of 4q2p by Molmil
NHERF3 PDZ2 in Complex with a Phage-Derived Peptide
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2014-04-09
Release date:2014-09-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014
4Q2N
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BU of 4q2n by Molmil
INADL PDZ3 in Complex with a Phage-Derived Peptide
Descriptor: 1,2-ETHANEDIOL, InaD-like protein
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2014-04-09
Release date:2014-09-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014
4NW6
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BU of 4nw6 by Molmil
Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27
Descriptor: 7-(1H-benzimidazol-7-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine, Ribosomal protein S6 kinase alpha-3
Authors:Appleton, B.A.
Deposit date:2013-12-05
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014

 

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