Author results

1JDS
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5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEX WITH PHOSPHATE (SPACE GROUP P21)
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, PHOSPHATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JDT
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH MTA AND SULFATE ION
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, SULFATE ION, 5'-DEOXY-5'-METHYLTHIOADENOSINE
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JDU
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JDV
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH ADENOSINE AND SULFATE ION
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, SULFATE ION, ADENOSINE
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JDZ
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE WITH FORMYCIN B AND SULFATE ION
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, SULFATE ION, FORMYCIN B
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JE0
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH PHOSPHATE AND TRIS MOLECULE
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, PHOSPHATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JE1
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5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEX WITH GUANOSINE AND SULFATE
Descriptor:5'-METHYLTHIOADENOSINE PHOSPHORYLASE, SULFATE ION, GUANOSINE
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-06-15
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JP7
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE
Descriptor:5'-deoxy-5'-methylthioadenosine phosphorylase, SULFATE ION
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-08-01
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1JPV
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH SO4
Descriptor:5'-deoxy-5'-methylthioadenosine phosphorylase, SULFATE ION
Authors:Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Deposit date:2001-08-03
Release date:2001-10-26
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
J.Biol.Chem., 276, 2001
1CB0
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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE AT 1.7 A RESOLUTION
Descriptor:PROTEIN (5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE), ADENINE
Authors:Appleby, T.C., Erion, M.D., Ealick, S.E.
Deposit date:1999-02-26
Release date:1999-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis.
Structure Fold.Des., 7, 1999
1CG6
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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION
Descriptor:PROTEIN (5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE), SULFATE ION, 5'-DEOXY-5'-METHYLTHIOADENOSINE
Authors:Appleby, T.C., Erion, M.D., Ealick, S.E.
Deposit date:1999-03-27
Release date:1999-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis.
Structure Fold.Des., 7, 1999
1DBT
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CRYSTAL STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM BACILLUS SUBTILIS COMPLEXED WITH UMP
Descriptor:OROTIDINE 5'-PHOSPHATE DECARBOXYLASE, URIDINE-5'-MONOPHOSPHATE
Authors:Appleby, T.C., Kinsland, C.L., Begley, T.P., Ealick, S.E.
Deposit date:1999-11-03
Release date:2000-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
Proc.Natl.Acad.Sci.USA, 97, 2000
1TP7
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CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE FROM HUMAN RHINOVIRUS 16
Descriptor:Genome polyprotein, SULFATE ION, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE
Authors:Appleby, T.C., Luecke, H., Shim, J.H., Wu, J.Z., Cheney, I.W., Zhong, W., Vogeley, L., Hong, Z., Yao, N.
Deposit date:2004-06-15
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer.
J.Virol., 79, 2005
1XRJ
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RAPID STRUCTURE DETERMINATION OF HUMAN URIDINE-CYTIDINE KINASE 2 USING A CONVENTIONAL LABORATORY X-RAY SOURCE AND A SINGLE SAMARIUM DERIVATIVE
Descriptor:Uridine-cytidine kinase 2, MAGNESIUM ION, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Appleby, T.C., Larson, G., Wu, J.Z., Cheney, I.W., Hong, Z., Yao, N.
Deposit date:2004-10-14
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.
Acta Crystallogr.,Sect.D, 61, 2005
3O8B
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VISUALIZING ATP-DEPENDENT RNA TRANSLOCATION BY THE NS3 HELICASE FROM HCV
Descriptor:HCV NS3 protease/helicase, ZINC ION, SULFATE ION
Authors:Appleby, T.C., Somoza, J.R.
Deposit date:2010-08-02
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV.
J.Mol.Biol., 405, 2011
3O8C
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VISUALIZING ATP-DEPENDENT RNA TRANSLOCATION BY THE NS3 HELICASE FROM HCV
Descriptor:HCV NS3 protease/helicase, RNA (5'-R(P*UP*(5BU)P*UP*UP*UP*U)-3'), ZINC ION, ...
Authors:Appleby, T.C., Somoza, J.R.
Deposit date:2010-08-02
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV.
J.Mol.Biol., 405, 2011
3O8D
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VISUALIZING ATP-DEPENDENT RNA TRANSLOCATION BY THE NS3 HELICASE FROM HCV
Descriptor:HCV NS3 protease/helicase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Appleby, T.C., Somoza, J.R.
Deposit date:2010-08-02
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV.
J.Mol.Biol., 405, 2011
3O8R
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VISUALIZING ATP-DEPENDENT RNA TRANSLOCATION BY THE NS3 HELICASE FROM HCV
Descriptor:HCV NS3 protease/helicase, RNA (5'-R(P*UP*(5BU)P*UP*UP*UP*U)-3'), ZINC ION, ...
Authors:Appleby, T.C., Somoza, J.R.
Deposit date:2010-08-03
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV.
J.Mol.Biol., 405, 2011
5TH6
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STRUCTURE DETERMINATION OF A POTENT, SELECTIVE ANTIBODY INHIBITOR OF HUMAN MMP9 (APO MMP9)
Descriptor:Matrix metalloproteinase-9,Matrix metalloproteinase-9, ZINC ION, CALCIUM ION
Authors:Appleby, T.C., Greenstein, A.E., Kwon, H.J.
Deposit date:2016-09-29
Release date:2017-03-01
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
J. Biol. Chem., 292, 2017
5TH9
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STRUCTURE DETERMINATION OF A POTENT, SELECTIVE ANTIBODY INHIBITOR OF HUMAN MMP9 (GS-5745 BOUND TO MMP-9)
Descriptor:GS-5745 Fab light chain, GS-5745 Fab heavy chain, Matrix metalloproteinase-9,Matrix metalloproteinase-9, ...
Authors:Appleby, T.C., Greenstein, A.E., Kwon, H.J.
Deposit date:2016-09-29
Release date:2017-03-15
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
J. Biol. Chem., 292, 2017
4WT9
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APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS
Descriptor:RNA-directed RNA polymerase, CHLORIDE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTA
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor:RNA PRIMER TEMPLATE CAAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTC
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU
Descriptor:RNA PRIMER TEMPLATE AGAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTD
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor:RNA PRIMER TEMPLATE AUAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Fox III, D., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTE
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU
Descriptor:RNA PRIMER TEMPLATE ACAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
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