Author results

2NWN
  • Download 2nwn
  • View 2nwn
Molmil generated image of 2nwn
NEW PHARMACOPHORE FOR SERINE PROTEASE INHIBITION REVEALED BY CRYSTAL STRUCTURE OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR COMPLEXED WITH A CYCLIC PEPTIDYL INHIBITOR, UPAIN-1
Descriptor:Plasminogen activator, urokinase, upain-1
Authors:Zhao, G., Yuan, C., Wind, T., Andreasen, P.A., Huang, Z., Huang, M., Structural Genomics Consortium (SGC)
Deposit date:2006-11-16
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
3M61
  • Download 3m61
  • View 3m61
Molmil generated image of 3m61
CRYSTAL STRUCTURE OF COMPLEX OF UROKINASE AND A UPAIN-1 VARIANT(W3A) IN PH4.6 CONDITION
Descriptor:Urokinase-type plasminogen activator, upain-1 W3A
Authors:Jiang, L., Yuan, C., Wind, T., Andreasen, P.A., Chen, L., Meehan, E.J., Huang, M.
Deposit date:2010-03-15
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition
TO BE PUBLISHED
3OX7
  • Download 3ox7
  • View 3ox7
Molmil generated image of 3ox7
THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION, ...
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-21
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
  • Download 3oy5
  • View 3oy5
Molmil generated image of 3oy5
THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH7.4
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY6
  • Download 3oy6
  • View 3oy6
Molmil generated image of 3oy6
THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH036 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH036
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3UT3
  • Download 3ut3
  • View 3ut3
Molmil generated image of 3ut3
A NOVEL PAI-I INHIBITOR AND ITS STRUCTURAL MECHANISM
Descriptor:Plasminogen activator inhibitor 1, 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Authors:Lin, Z.H., Hong, Z.B., Shi, X.L., Hu, L.H., Andreasen, P.A., Huang, M.D.
Deposit date:2011-11-25
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A novel PAI-I inhibitor and its structural mechanism
To be Published
4DVA
  • Download 4dva
  • View 4dva
Molmil generated image of 4dva
THE CRYSTAL STRUCTURE OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR CATALYTIC DOMAIN
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, HEXAETHYLENE GLYCOL
Authors:Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.
Deposit date:2012-02-23
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Rezymogenation of active urokinase induced by an inhibitory antibody
Biochem.J., 449, 2013
4DVB
  • Download 4dvb
  • View 4dvb
Molmil generated image of 4dvb
THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF PRO-UPA ANTIBODY MAB-112
Descriptor:Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, TETRAETHYLENE GLYCOL
Authors:Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.
Deposit date:2012-02-23
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
4DW2
  • Download 4dw2
  • View 4dw2
Molmil generated image of 4dw2
THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH THE FAB FRAGMENT OF MAB-112
Descriptor:Urokinase-type plasminogen activator, Fab fragment of pro-uPA antibody mAb-112, SULFATE ION
Authors:Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M.
Deposit date:2012-02-24
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
4ZHL
  • Download 4zhl
  • View 4zhl
Molmil generated image of 4zhl
THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MURINISED HUMAN UPA AT PH7.4
Descriptor:Urokinase-type plasminogen activator, mupain-1-IG
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-25
Release date:2015-09-16
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4ZHM
  • Download 4zhm
  • View 4zhm
Molmil generated image of 4zhm
THE CRYSTAL STRUCTURE OF MUPAIN-1--16-IG IN COMPLEX WITH MURINISED HUMAN UPA AT PH7.4
Descriptor:mupain-1-16-IG, Urokinase-type plasminogen activator, piperidine-1-carboximidamide
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-25
Release date:2015-09-16
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4ZKN
  • Download 4zkn
  • View 4zkn
Molmil generated image of 4zkn
THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH UPA AT PH5.5
Descriptor:Urokinase-type plasminogen activator, upain-1-W3A, SULFATE ION, ...
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKO
  • Download 4zko
  • View 4zko
Molmil generated image of 4zko
THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH UPA AT PH7.4
Descriptor:Urokinase-type plasminogen activator, N-terminal fragment of upain-1-W3A, C-terminal fragment of upain-1-W3A, ...
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKR
  • Download 4zkr
  • View 4zkr
Molmil generated image of 4zkr
THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH UPA AT PH9.0
Descriptor:Urokinase-type plasminogen activator, upain-1-W3A, SULFATE ION, ...
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKS
  • Download 4zks
  • View 4zks
Molmil generated image of 4zks
THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH INACTIVE UPA (UPA-S195A) AT PH7.4
Descriptor:Urokinase-type plasminogen activator, upain-1-W3A
Authors:Jiang, L., Andreasen, P.A., Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
5EZD
  • Download 5ezd
  • View 5ezd
Molmil generated image of 5ezd
CRYSTAL STRUCTURE OF A HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR-1 (HAI-1) FRAGMENT COVERING THE PKD-LIKE 'INTERNAL' DOMAIN AND KUNITZ DOMAIN 1
Descriptor:Kunitz-type protease inhibitor 1, POTASSIUM ION, ACETATE ION
Authors:Hong, Z., Andreasen, P.A., Morth, J.P., Jensen, J.K.
Deposit date:2015-11-26
Release date:2016-05-18
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
5HGG
  • Download 5hgg
  • View 5hgg
Molmil generated image of 5hgg
CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH A CAMELID-DERIVED ANTIBODY FRAGMENT
Descriptor:Urokinase-type plasminogen activator, Camelid Derived Antibody Fragment, Nb4, ...
Authors:Yung, K.W.Y., Kromann-Hansen, T., Andreasen, P.A., Ngo, J.C.K.
Deposit date:2016-01-08
Release date:2016-06-01
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior
J.Biol.Chem., 291, 2016
5LHN
  • Download 5lhn
  • View 5lhn
Molmil generated image of 5lhn
THE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
  • Download 5lhp
  • View 5lhp
Molmil generated image of 5lhp
THE P-AMINOBENZAMIDINE ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment, SULFATE ION, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
  • Download 5lhq
  • View 5lhq
Molmil generated image of 5lhq
THE EGR-CMK ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHR
  • Download 5lhr
  • View 5lhr
Molmil generated image of 5lhr
THE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ACTIVE SITE BINDING INHIBITORY NANOBODY NB22
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb22
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
  • Download 5lhs
  • View 5lhs
Molmil generated image of 5lhs
THE LIGAND FREE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, NICKEL (II) ION
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
6A8G
  • Download 6a8g
  • View 6a8g
Molmil generated image of 6a8g
THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:muPAin-1-IG, Urokinase-type plasminogen activator chain B, PHOSPHATE ION
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-08
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
To Be Published
6A8N
  • Download 6a8n
  • View 6a8n
Molmil generated image of 6a8n
THE CRYSTAL STRUCTURE OF MUPAIN-1-IG-2 IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-09
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
To Be Published
4X0W
  • Download 4x0w
  • View 4x0w
Molmil generated image of 4x0w
THE CRYSTAL STRUCTURE OF MUPAIN-1-17 IN COMPLEX WITH MURINISED HUMAN UPA
Descriptor:mupain-1-17, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ...
Authors:Jiang, L., Zhao, B., Xu, P., Andreasen, P., Huang, M.
Deposit date:2014-11-24
Release date:2015-10-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues.
Int.J.Biochem.Cell Biol., 62, 2015
<12>