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1J8T
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CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE FE(II)
Descriptor:PHENYLALANINE-4-HYDROXYLASE, FE (II) ION
Authors:Andersen, O.A., Flatmark, T., Hough, E.
Deposit date:2001-05-22
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
J.Mol.Biol., 314, 2001
1J8U
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CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE FE(II) IN COMPLEX WITH TETRAHYDROBIOPTERIN
Descriptor:PHENYLALANINE-4-HYDROXYLASE, FE (II) ION, 5,6,7,8-TETRAHYDROBIOPTERIN
Authors:Andersen, O.A., Flatmark, T., Hough, E.
Deposit date:2001-05-22
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
J.Mol.Biol., 314, 2001
1KW0
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CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE (FE(II)) IN COMPLEX WITH TETRAHYDROBIOPTERIN AND THIENYLALANINE
Descriptor:Phenylalanine-4-hydroxylase, FE (II) ION, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Andersen, O.A., Flatmark, T., Hough, E.
Deposit date:2002-01-28
Release date:2003-01-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation
J.Mol.Biol., 320, 2002
1MMK
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CRYSTAL STRUCTURE OF TERNARY COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE ((FEII)) COMPLEXED WITH TETRAHYDROBIOPTERIN AND THIENYLALANINE
Descriptor:Phenylalanine-4-hydroxylase, FE (II) ION, SULFATE ION, ...
Authors:Andersen, O.A., Flatmark, T., Hough, E.
Deposit date:2002-09-04
Release date:2003-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding
J.Mol.Biol., 333, 2003
1MMT
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CRYSTAL STRUCTURE OF TERNARY COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE (FE(II)) COMPLEXED WITH TETRAHYDROBIOPTERIN AND NORLEUCINE
Descriptor:Phenylalanine-4-hydroxylase, FE (II) ION, SULFATE ION, ...
Authors:Andersen, O.A., Flatmark, T., Hough, E.
Deposit date:2002-09-04
Release date:2003-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding
J.Mol.Biol., 333, 2003
2WEY
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HUMAN PDE-PAPAVERINE COMPLEX OBTAINED BY LIGAND SOAKING OF CROSS- LINKED PROTEIN CRYSTALS
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, ...
Authors:Andersen, O.A., Schonfeld, D.L., Toogood-Johnson, I., Felicetti, B., Albrecht, C., Fryatt, T., Whittaker, M., Hallett, D., Barker, J.
Deposit date:2009-04-02
Release date:2009-07-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure.
Acta Crystallogr.,Sect.D, 65, 2009
3CH9
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH DIMETHYLGUANYLUREA
Descriptor:Chitinase, SULFATE ION, 1-methyl-3-(N-methylcarbamimidoyl)urea
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHC
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH MONOPEPTIDE
Descriptor:Chitinase, SULFATE ION, (2S)-2-acetamido-N-methyl-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]pentanamide
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHD
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH DIPEPTIDE
Descriptor:Chitinase, (2S)-2-[[(2S)-2-acetamido-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]pentanoyl]-methyl-amino]-3-phenyl-propanoic acid, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHE
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH TRIPEPTIDE
Descriptor:Chitinase, Peptide inhibitor, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHF
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH TETRAPEPTIDE
Descriptor:Chitinase, Argifin, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
5CPH
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, (3E)-3-(pyridin-3-ylmethylidene)-1,3-dihydro-2H-indol-2-one, SULFATE ION, ...
Authors:Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-21
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
5CTU
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-24
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
5CTW
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, 2-(butanoylamino)thiophene-3-carboxamide, MAGNESIUM ION, ...
Authors:Andersen, O.A., Barker, J., Hadfield, A.T., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-24
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
5CTX
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, (4S)-2-METHYL-2,4-PENTANEDIOL, 4-phenyl-3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, ...
Authors:Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-24
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
5CTY
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Andersen, O.A., Barker, J., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-24
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
1UTJ
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSIN I, BENZYLAMINE, CALCIUM ION
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTK
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSIN I, SULFATE ION, CALCIUM ION
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTL
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSIN I, 3-PHENYLPROPYLAMINE, CALCIUM ION, ...
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTM
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSIN I, 2-PHENYLETHYLAMINE, CALCIUM ION
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTN
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSINOGEN, BENZYLAMINE, SULFATE ION, ...
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTO
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSINOGEN, 2-PHENYLETHYLAMINE, GLYCEROL, ...
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTP
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSINOGEN, 4-PHENYLBUTYLAMINE, GLYCEROL, ...
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
1UTQ
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TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS
Descriptor:TRYPSINOGEN, GLYCEROL, CALCIUM ION
Authors:Leiros, H.-K.S., Brandsdal, B.O., Andersen, O.A., Os, V., Leiros, I., Helland, R., Otlewski, J., Willassen, N.P., Smalas, A.O.
Deposit date:2003-12-09
Release date:2004-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
2A3A
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH THEOPHYLLINE
Descriptor:chitinase, SULFATE ION, THEOPHYLLINE
Authors:Rao, F.V., Andersen, O.A., Vora, K.A., DeMartino, J.A., van Aalten, D.M.F.
Deposit date:2005-06-24
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol., 12, 2005
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