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2D05
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CHITOSANASE FROM BACILLUS CIRCULANS MUTANT K218P
Descriptor:Chitosanase, SULFATE ION
Authors:Fukamizo, T., Amano, S., Yamaguchi, K., Yoshikawa, T., Katsumi, T., Saito, J., Suzuki, M., Miki, K., Nagata, Y., Ando, A.
Deposit date:2005-07-25
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bacillus circulans MH-K1 Chitosanase: Amino Acid Residues Responsible for Substrate Binding
J.Biochem.(Tokyo), 138, 2005
4PM0
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PDE7A CATALYTIC DOMAIN IN COMPLEX WITH 2-(CYCLOPENTYLAMINO)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE DERIVATIVE
Descriptor:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ...
Authors:Kawai, K., Endo, Y., Asano, T., Amano, S., Sawada, K., Ueo, N., Takahashi, N., Sonoda, Y., Kamei, N., Nagata, N.
Deposit date:2014-05-20
Release date:2014-12-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one Derivatives as a New Series of Potent Phosphodiesterase 7 Inhibitors.
J.Med.Chem., 57, 2014
4Y2B
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CO-CRYSTAL STRUCTURE OF 3-ETHYL-2-(ISOPROPYLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE BOUND TO PDE7A
Descriptor:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ...
Authors:Endo, Y., Kawai, K., Asano, T., Amano, S., Asanuma, Y., Sawada, K., Onodera, Y., Ueo, N., Takahashi, N., Sonoda, Y., Kamei, N., Irie, T.
Deposit date:2015-02-09
Release date:2015-04-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy
Bioorg.Med.Chem.Lett., 25, 2015