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5M2F
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CRYSTAL STRUCTURE OF HUMAN AKR1B10 COMPLEXED WITH NADP+ AND THE SYNTHETIC RETINOID UVI2008
Descriptor:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-bromo-4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid, ...
Authors:Ruiz, F.X., Cousido-Siah, A., Mitschler, A., Porte, S., Alvarez, S., Dominguez, M., Alvarez, R., de Lera, A.R., Pares, X., Farres, J., Podjarny, A.
Deposit date:2016-10-12
Release date:2017-02-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.
Chem. Biol. Interact., 276, 2017
4GXO
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS PROTEIN SARZ MUTANT C13E
Descriptor:MarR family regulatory protein, GLYCEROL
Authors:Sun, F., Ding, Y., Ji, Q., Liang, Z., Deng, X., Wong, C.C., Yi, C., Zhang, L., Xie, S., Alvarez, S., Hicks, L.M., Luo, C., Jiang, H., Lan, L., He, C.
Deposit date:2012-09-04
Release date:2012-09-26
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Proc.Natl.Acad.Sci.USA, 109, 2012
3G5K
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STRUCTURE AND ACTIVITY OF HUMAN MITOCHONDRIAL PEPTIDE DEFORMYLASE, A NOVEL CANCER TARGET
Descriptor:Peptide deformylase, mitochondrial, ACTINONIN, ...
Authors:Escobar-Alvarez, S., Goldgur, Y., Yang, G., Ouerfelli, O., Li, Y., Scheinberg, D.A.
Deposit date:2009-02-05
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and activity of human mitochondrial peptide deformylase, a novel cancer target
J.Mol.Biol., 387, 2009
3G5P
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STRUCTURE AND ACTIVITY OF HUMAN MITOCHONDRIAL PEPTIDE DEFORMYLASE, A NOVEL CANCER TARGET
Descriptor:Peptide deformylase, mitochondrial, COBALT (II) ION, ...
Authors:Escobar-Alvarez, S., Goldgur, Y., Yang, G., Ouerfelli, O., Li, Y., Scheinberg, D.A.
Deposit date:2009-02-05
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and activity of human mitochondrial peptide deformylase, a novel cancer target
J.Mol.Biol., 387, 2009
3KMR
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CRYSTAL STRUCTURE OF RARALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH AN AGONIST LIGAND (AM580) AND A COACTIVATOR FRAGMENT
Descriptor:Retinoic acid receptor alpha, Nuclear receptor coactivator 1, 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid
Authors:Bourguet, W., Teyssier, C.
Deposit date:2009-11-11
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Nat.Struct.Mol.Biol., 17, 2010
3KMZ
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CRYSTAL STRUCTURE OF RARALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH THE INVERSE AGONIST BMS493 AND A COREPRESSOR FRAGMENT
Descriptor:Retinoic acid receptor alpha, Nuclear receptor corepressor 1, 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid, ...
Authors:Bourguet, W., le Maire, A.
Deposit date:2009-11-11
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Nat.Struct.Mol.Biol., 17, 2010
4ZSH
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RXR LBD IN COMPLEX WITH 9-CIS-13,14-DIHYDRORETINOIC ACID
Descriptor:Retinoic acid receptor RXR-alpha, NCoA2 peptide, (5S,6S,9R,13R)-2,3-didehydro-5,6,7,8,9,10,11,12,13,14-decahydroretinoic acid
Authors:Rochel, N., Krezel, W., Ruhl, R.
Deposit date:2015-05-13
Release date:2016-03-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.
Plos Genet., 11, 2015
5KOD
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CRYSTAL STRUCTURE OF GH3.5 ACYL ACID AMIDO SYNTHETASE FROM ARABIDOPSIS THALIANA
Descriptor:Indole-3-acetic acid-amido synthetase GH3.5, ADENOSINE MONOPHOSPHATE, 1H-INDOL-3-YLACETIC ACID, ...
Authors:Jez, J.M., Westfall, C.S., Zubieta, C.
Deposit date:2016-06-30
Release date:2016-11-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Arabidopsis thaliana GH3.5 acyl acid amido synthetase mediates metabolic crosstalk in auxin and salicylic acid homeostasis.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6AVH
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GH3.15 ACYL ACID AMIDO SYNTHETASE
Descriptor:GH3.15 acyl acid amido synthetase, ADENOSINE MONOPHOSPHATE
Authors:Sherp, A.M., Jez, J.M.
Deposit date:2017-09-02
Release date:2018-02-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Arabidopsis thalianaGH3.15 acyl acid amido synthetase has a highly specific substrate preference for the auxin precursor indole-3-butyric acid.
J. Biol. Chem., 293, 2018