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10MH
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Descriptor:DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ...
Authors:Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Deposit date:1998-08-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
5JFO
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STRUCTURE OF THE M.TUBERCULOSIS ENOYL-REDUCTASE INHA IN COMPLEX WITH GSK625
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-{1-[(2-chloro-6-fluorophenyl)methyl]-1H-pyrazol-3-yl}-5-[(1S)-1-(3-methyl-1H-pyrazol-1-yl)ethyl]-1,3,4-thiadiazol-2-amine
Authors:Gulten, G., Sacchettini, J.C.
Deposit date:2016-04-19
Release date:2016-08-10
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
Ebiomedicine, 8, 2016