Author results

6DY7
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WDR5 IN COMPLEX WITH A WIN SITE INHIBITOR
Descriptor:WD repeat-containing protein 5, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, DIMETHYL SULFOXIDE, ...
Authors:Phan, J., Wang, F., Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6DYA
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WDR5 IN COMPLEX WITH A WIN SITE INHIBITOR
Descriptor:WD repeat-containing protein 5, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ...
Authors:Phan, J., Wang, F., Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Y
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Z
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E22
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E23
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6D9X
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, SODIUM ION, 2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-04-30
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAI
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, DIMETHYL SULFOXIDE, 6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAK
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-{[3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenyl]methyl}benzamide, DIMETHYL SULFOXIDE
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAR
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-(cyclopropylmethyl)-N-{[3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenyl]methyl}-3-methoxybenzamide, SULFATE ION, ...
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-09-05
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
6DAS
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-05-01
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J. Med. Chem., 61, 2018
2R0B
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE-LIKE SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
Descriptor:Serine/threonine/tyrosine-interacting protein, SULFATE ION, GLYCEROL
Authors:Bonanno, J.B., Freeman, J., Bain, K.T., Iizuka, M., Romero, R., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-08-18
Release date:2007-08-28
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2QJC
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CRYSTAL STRUCTURE OF A PUTATIVE DIADENOSINE TETRAPHOSPHATASE
Descriptor:Diadenosine tetraphosphatase, putative, MANGANESE (II) ION, ...
Authors:Sugadev, R., Burley, S.K., Swaminathan, S., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-07-06
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2Q5E
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CRYSTAL STRUCTURE OF HUMAN CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 2
Descriptor:Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, MAGNESIUM ION
Authors:Bonanno, J.B., Dickey, M., Bain, K.T., Lau, C., Romero, R., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-05-31
Release date:2007-06-19
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2P69
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CRYSTAL STRUCTURE OF HUMAN PYRIDOXAL PHOSPHATE PHOSPHATASE WITH PLP
Descriptor:Pyridoxal phosphate phosphatase, CALCIUM ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Ramagopal, U.A., Freeman, J., Izuka, M., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-16
Release date:2007-04-03
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2P8E
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CRYSTAL STRUCTURE OF THE SERINE/THREONINE PHOSPHATASE DOMAIN OF HUMAN PPM1B
Descriptor:PPM1B beta isoform variant 6, MAGNESIUM ION
Authors:Bonanno, J.B., Freeman, J., Bain, K.T., Lau, C., Xu, W., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-22
Release date:2007-04-03
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.816 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2PBN
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE RECEPTOR PHOSPHATE GAMMA
Descriptor:Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION
Authors:Bonanno, J.B., Freeman, J., Bain, K.T., Reyes, C., Pelletier, L., Jin, X., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-28
Release date:2007-04-03
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2P4U
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CRYSTAL STRUCTURE OF ACID PHOSPHATASE 1 (ACP1) FROM MUS MUSCULUS
Descriptor:Acid phosphatase 1, PHOSPHATE ION
Authors:Bonanno, J.B., Freeman, J., Bain, K.T., Wu, B., Xu, W., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-13
Release date:2007-03-20
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2OYC
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CRYSTAL STRUCTURE OF HUMAN PYRIDOXAL PHOSPHATE PHOSPHATASE
Descriptor:Pyridoxal phosphate phosphatase, SODIUM ION, TUNGSTATE(VI)ION
Authors:Ramagopal, U.A., Freeman, J., Izuka, M., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-02-21
Release date:2007-03-13
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2P27
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CRYSTAL STRUCTURE OF HUMAN PYRIDOXAL PHOSPHATE PHOSPHATASE WITH MG2+ AT 1.9 A RESOLUTION
Descriptor:Pyridoxal phosphate phosphatase, MAGNESIUM ION
Authors:Ramagopal, U.A., Freeman, J., Izuka, M., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-07
Release date:2007-03-13
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2NX2
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CRYSTAL STRUCTURE OF PROTEIN YPSA FROM BACILLUS SUBTILIS, PFAM DUF1273
Descriptor:Hypothetical protein ypsA
Authors:Ramagopal, U.A., Alvarado, J., Dickey, M., Reyes, C., Toro, R., Bain, K., Gheyi, T., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-11-16
Release date:2006-12-19
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of hypothetical protein ypsA from Bacillus subtilis.
To be Published
2NV5
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CRYSTAL STRUCTURE OF A C-TERMINAL PHOSPHATASE DOMAIN OF RATTUS NORVEGICUS ORTHOLOG OF HUMAN PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, D (PTPRD)
Descriptor:PTPRD, PHOSPHATASE
Authors:Bonanno, J.B., Gilmore, J., Bain, K.T., Iizuka, M., Xu, W., Wasserman, S., Smith, D., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-11-10
Release date:2006-11-21
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
2IRM
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CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 INTERACTING PROTEIN 1 FROM ANOPHELES GAMBIAE
Descriptor:mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Authors:Jin, X., Bonanno, J.B., Pelletier, L., Freeman, J.C., Wasserman, S., Sauder, J.M., Burley, S.K., Shapiro, L., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-10-15
Release date:2006-11-14
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
2IQ1
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CRYSTAL STRUCTURE OF HUMAN PPM1K
Descriptor:Protein phosphatase 2C kappa, PPM1K, MAGNESIUM ION
Authors:Bonanno, J.B., Freeman, J., Russell, M., Bain, K.T., Adams, J., Pelletier, L., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-10-12
Release date:2006-11-07
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural genomics of protein phosphatases
J.STRUCT.FUNCT.GENOM., 8, 2007
2ISN
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CRYSTAL STRUCTURE OF A PHOSPHATASE FROM A PATHOGENIC STRAIN TOXOPLASMA GONDII
Descriptor:NYSGXRC-8828z, phosphatase, SULFATE ION, ...
Authors:Agarwal, R., Burley, S.K., Swaminathan, S., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-10-18
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
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