Author results

2XRU
  • Download 2xru
  • View 2xru
Molmil generated image of 2xru
AURORA-A T288E COMPLEXED WITH PHA-828300
分子名称:SERINE/THREONINE-PROTEIN KINASE 6, 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE
著者Bindi, S., Fancelli, D., Alli, C., Berta, D., Bertrand, J.A., Cameron, A.D., Cappella, P., Carpinelli, P., Cervi, G., Croci, W., D'Anello, M., Forte, B., LauraGiorgini, M., Marsiglio, A., Moll, J., Pesenti, E., Pittala, V., Pulici, M., Riccardi-Sirtori, F., Roletto, F., Soncini, C., Storici, P., Varasi, M., Volpi, D., Zugnoni, P., Vianello, P.
登録日2010-09-22
公開日2010-09-29
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity.
Bioorg.Med.Chem., 18, 2010
5NGE
  • Download 5nge
  • View 5nge
Molmil generated image of 5nge
CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE NON-COVALENT INHIBITOR, FT671
分子名称:Ubiquitin carboxyl-terminal hydrolase 7, 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
著者Turnbull, A.P., Krajewski, W.W., Ioannidis, S., Kessler, B.M., Komander, D.
登録日2017-03-17
公開日2017-10-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5NGF
  • Download 5ngf
  • View 5ngf
Molmil generated image of 5ngf
CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE COVALENT INHIBITOR, FT827
分子名称:Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL
著者Krajewski, W.W., Turnbull, A.P., Ioannidis, S., Kessler, B.M., Komander, D.
登録日2017-03-17
公開日2017-10-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017