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2XDP
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN JMJD2C
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4C, SULFATE ION
Authors:Yue, W.W., Gileadi, C., Krojer, T., Weisbach, H., Ugochukwu, E., Daniel, M., Phillips, C., Chaikuad, A., von Delft, F., Allerston, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-05-06
Release date:2010-06-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal Structure of the Tudor Domain of Human Jmjd2C
To be Published
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
Descriptor:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
4HAS
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CRYSTAL STRUCTURE OF PX DOMAIN OF HUMAN SORTING NEXIN SNX27
Descriptor:Sorting nexin-27, CITRIC ACID, 1,2-ETHANEDIOL
Authors:Froese, D.S., Krojer, T., Strain-Damerell, C., Allerston, C., Kiyani, W., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2012-09-27
Release date:2013-04-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of PX domain of human sorting nexin SNX27
To be Published
2X4D
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE LHPP
Descriptor:PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Vollmar, M., Gileadi, C., Guo, K., Savitsky, P., Muniz, J.R.C., Yue, W., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-01-29
Release date:2010-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal Structure of Human Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase Lhpp
To be Published
2XZZ
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CRYSTAL STRUCTURE OF THE HUMAN TRANSGLUTAMINASE 1 BETA-BARREL DOMAIN
Descriptor:PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K
Authors:Vollmar, M., Krysztofinska, E., Krojer, T., Yue, W.W., Cooper, C., Kavanagh, K., Allerston, C., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-30
Release date:2011-01-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain
To be Published
2YAN
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CRYSTAL STRUCTURE OF THE SECOND GLUTAREDOXIN DOMAIN OF HUMAN TXNL2
Descriptor:GLUTAREDOXIN-3, 1,2-ETHANEDIOL, FE (III) ION, ...
Authors:Vollmar, M., Johansson, C., Cocking, R., Muniz, J.R.C., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-02-23
Release date:2011-11-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Second Glutaredoxin Domain of Human Txnl2
To be Published
4AAP
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CRYSTAL STRUCTURE OF JMJD5 DOMAIN OF HUMAN LYSINE-SPECIFIC DEMETHYLASE 8 (KDM8) IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 8, ZINC ION, N-OXALYLGLYCINE
Authors:Vollmar, M., Johansson, C., Krojer, T., Canning, P., Allerston, C., Gadhave, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-12-05
Release date:2012-02-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Jmjd5 Domain of Human Lysine- Specific Demethylase 8 (Kdm8) in Complex with N- Oxalylglycine (Nog)
To be Published
4AGU
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CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Authors:Canning, P., Sharpe, T.D., Allerston, C., Savitsky, P., Pike, A.C.W., Muniz, J.R.C., Chaikuad, A., Kuo, K., Burgess-Brown, N., Ayinampudi, V., Zhang, Y., Thangaratnarajah, C., Ugochukwu, E., Vollmar, M., Krojer, T., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Knapp, S., Bullock, A.
Deposit date:2012-01-31
Release date:2012-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Cdkl1 Kinase Domain
To be Published
2XIK
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STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)
Descriptor:SERINE/THREONINE PROTEIN KINASE 25, 1,2-ETHANEDIOL, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Authors:Muniz, J.R.C., Rellos, P., Ugochukwu, E., Vollmar, M., Allerston, C., Chaikuad, A., Savitsky, P., Berridge, G., Brenner, B., Elkins, J.M., Daga, N., Gileadi, O., Mahajan, P., Shrestha, B., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of Human Ysk1 (Yeast Sps1-Ste20-Related Kinase 1)
To be Published
3L5K
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THE CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1A (HDHD1A)
Descriptor:Haloacid dehalogenase-like hydrolase domain-containing protein 1A, POTASSIUM ION, GLYCEROL, ...
Authors:Ugochukwu, E., Guo, K., Picaud, S., Muniz, J., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Yue, W.W., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-12-22
Release date:2010-03-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human Haloacid Dehalogenase-like Hydrolase Domain containing 1A (HDHD1A)
To be Published
3QWM
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CRYSTAL STRUCTURE OF GEP100, THE PLEXTRIN HOMOLOGY DOMAIN OF IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1 ISOFORM A
Descriptor:IQ motif and SEC7 domain-containing protein 1
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Feller, S., Janning, M., Sabe, H., Krojer, T., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2011-02-28
Release date:2011-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal Structure of GEP100, the plextrin homology domain of IQ motif and SEC7 domain-containing protein 1 isoform a
to be published
4A27
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CRYSTAL STRUCTURE OF HUMAN SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE PROTEIN
Descriptor:SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE, 1,2-ETHANEDIOL
Authors:Vollmar, M., Shafqat, N., Muniz, J.R.C., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Yue, W.W., Oppermann, U.
Deposit date:2011-09-22
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Human Synaptic Vesicle Membrane Protein Vat-1 Homolog-Like Protein
To be Published
4AP8
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CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT (MOCS2B)
Descriptor:MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT, GLYCEROL, 1,2-ETHANEDIOL
Authors:Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Allerston, C., Froese, D.S., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
Deposit date:2012-03-30
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Crystal Structure of Human Molybdopterin Synthase Catalytic Subunit (Mocs2B)
To be Published
5APA
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CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASE ISOFORM A
Descriptor:ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE, NICKEL (II) ION, (2S)-2-hydroxybutanedioic acid, ...
Authors:Krojer, T., Kochan, G., Pfeffer, I., McDonough, M.A., Pilka, E., Hozjan, V., Allerston, C., Muniz, J.R., Chaikuad, A., Gileadi, O., Kavanagh, K., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2015-09-15
Release date:2015-09-23
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Human Aspartate Beta- Hydroxylase Isoform A
To be Published
3HMI
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THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Descriptor:Tyrosine-protein kinase ABL2, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Authors:Ugochukwu, E., Salah, E., Barr, A., Mahajan, P., Shrestha, B., Savitsky, P., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-07-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
To be Published
2YGW
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CRYSTAL STRUCTURE OF HUMAN MCD
Descriptor:MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL, UNKNOWN ATOM OR ION, ...
Authors:Vollmar, M., Puranik, S., Krojer, T., Savitsky, P., Allerston, C., Yue, W.W., Chaikuad, A., von Delft, F., Gileadi, O., Kavanagh, K., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-04-21
Release date:2012-02-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations.
Structure, 21, 2013
2WWU
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PHD FINGER PROTEIN 8
Descriptor:PHD FINGER PROTEIN 8, SULFATE ION, ACETATE ION, ...
Authors:Yue, W.W., Hozjan, V., Cooper, C., Tumber, A., Krojer, T., Muniz, J., Allerston, C., Salah, E., McDonough, M.A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Schofield, C.J., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-29
Release date:2009-11-17
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
FEBS Lett., 584, 2010
4D0N
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AKAP13 (AKAP-LBC) RHOGEF DOMAIN IN COMPLEX WITH RHOA
Descriptor:TRANSFORMING PROTEIN RHOA, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4D0O
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AKAP13 (AKAP-LBC) DH DOMAIN
Descriptor:A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
2YD0
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CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Raynor, J., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QNF
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CRYSTAL STRUCTURE OF THE OPEN STATE OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:Endoplasmic reticulum aminopeptidase 1, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Harvey, D., Chaikuad, A., Allerston, C., Muniz, J.R.C., Raynor, J., Ugochukwu, E., Berridge, G., Wordsworth, B.P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-02-08
Release date:2011-02-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011