Author results

3DH3
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CRYSTAL STRUCTURE OF RLUF IN COMPLEX WITH A 22 NUCLEOTIDE RNA SUBSTRATE
Descriptor:Ribosomal large subunit pseudouridine synthase F, stem loop fragment of E. Coli 23S RNA
Authors:Alian, A., DeGiovanni, A., Stroud, R.M., Finer-Moore, J.S.
Deposit date:2008-06-16
Release date:2009-04-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
J.Mol.Biol., 388, 2009
3BT7
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STRUCTURE OF E. COLI 5-METHYLURIDINE METHYLTRANSFERASE TRMA IN COMPLEX WITH 19 NUCLEOTIDE T-ARM ANALOGUE
Descriptor:tRNA (uracil-5-)-methyltransferase, RNA (5'-D(P*GP*CP*UP*GP*UP*GP*(5MU)P*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*GP*C)-3')
Authors:Alian, A., Stroud, R.M., Finer-Moore, J.
Deposit date:2007-12-27
Release date:2008-04-29
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2H7Q
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CYTOCHROME P450CAM COMPLEXED WITH IMIDAZOLE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, IMIDAZOLE
Authors:Verras, A., Alian, A., Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
2H7R
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L244A MUTANT OF CYTOCHROME P450CAM COMPLEXED WITH IMIDAZOLE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, 1-METHYLIMIDAZOLE
Authors:Verras, A., Alian, A., Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
2H7S
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L244A MUTANT OF CYTOCHROME P450CAM
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE
Authors:Verras, A., Alian, A., Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
4P9C
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CRYSTAL STRUCTURE OF DCMP DEAMINASE FROM THE CYANOPHAGE S-TIM5 IN COMPLEX WITH DCMP AND DUMP
Descriptor:Deoxycytidylate deaminase, ZINC ION, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Marx, A., Alian, A.
Deposit date:2014-04-03
Release date:2014-11-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The First Crystal Structure of a dTTP-bound Deoxycytidylate Deaminase Validates and Details the Allosteric-Inhibitor Binding Site.
J.Biol.Chem., 290, 2015
4P9D
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CRYSTAL STRUCTURE OF DCMP DEAMINASE FROM THE CYANOPHAGE S-TIM5 IN COMPLEX WITH DTMP AND DTTP.
Descriptor:Deoxycytidylate deaminase, ZINC ION, MAGNESIUM ION, ...
Authors:Marx, A., Alian, A.
Deposit date:2014-04-03
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The First Crystal Structure of a dTTP-bound Deoxycytidylate Deaminase Validates and Details the Allosteric-Inhibitor Binding Site.
J.Biol.Chem., 290, 2015
4P9E
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CRYSTAL STRUCTURE OF DCMP DEAMINASE FROM THE CYANOPHAGE S-TIM5 IN APO FORM
Descriptor:Deoxycytidylate deaminase, ZINC ION, CHLORIDE ION
Authors:Marx, A., Alian, A.
Deposit date:2014-04-03
Release date:2014-11-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The First Crystal Structure of a dTTP-bound Deoxycytidylate Deaminase Validates and Details the Allosteric-Inhibitor Binding Site.
J.Biol.Chem., 290, 2015
4WYV
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CRYSTAL STRUCTURE OF HUMAN TRANSLIN IN OPEN CONFORMATION
Descriptor:Translin
Authors:Dvir, H., Eliahoo, E., Alian, A.
Deposit date:2014-11-18
Release date:2014-11-26
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel open-barrel structure of octameric translin reveals a potential RNA entryway.
J.Mol.Biol., 427, 2015
5DCK
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CRYSTAL STRUCTURE OF FIV CAPSID C-TERMINAL DOMAIN
Descriptor:Capsid C-Terminal Domain
Authors:Galilee, M., Khwaja, A., Alian, A.
Deposit date:2015-08-24
Release date:2016-04-20
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of FIV capsid C-terminal domain demonstrates lentiviral evasion of genetic fragility by coevolved substitutions.
Sci Rep, 6, 2016
5EU7
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CRYSTAL STRUCTURE OF HIV-1 INTEGRASE CATALYTIC CORE IN COMPLEX WITH FAB
Descriptor:Integrase, FAB Heavy Chain, FAB light chain
Authors:Galilee, M., Griner, S.L., Stroud, R.M., Alian, A.
Deposit date:2015-11-18
Release date:2016-09-28
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Structure, 24, 2016
2NSD
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ENOYL ACYL CARRIER PROTEIN REDUCTASE INHA IN COMPLEX WITH N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
Descriptor:Enoyl-[acyl-carrier-protein] reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
Authors:He, X., Alian, A., Ortiz de Montellano, P.R.
Deposit date:2006-11-03
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.
Bioorg.Med.Chem., 15, 2007
4MQ3
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THE 1.1 ANGSTROM STRUCTURE OF CATALYTIC CORE DOMAIN OF FIV INTEGRASE
Descriptor:Integrase
Authors:Galilee, M., Alian, A.
Deposit date:2013-09-15
Release date:2014-09-17
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Identification of phe187 as a crucial dimerization determinant facilitates crystallization of a monomeric retroviral integrase core domain.
Structure, 22, 2014
4PA1
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CRYSTAL STRUCTURE OF CATALYTIC CORE DOMAIN OF FIV INTEGRASE
Descriptor:Integrase
Authors:Galilee, M., Alian, A.
Deposit date:2014-04-07
Release date:2014-09-17
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Identification of phe187 as a crucial dimerization determinant facilitates crystallization of a monomeric retroviral integrase core domain.
Structure, 22, 2014
4TRJ
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-06-17
Release date:2014-08-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4TZK
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-10
Release date:2014-08-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4TZT
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL- 5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-10
Release date:2014-08-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4U0J
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-11
Release date:2014-07-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
4U0K
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE COMPLEXED WITH N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
Authors:He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R.
Deposit date:2014-07-11
Release date:2014-07-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
5OVN
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CRYSTAL STRUCURE OF FIV REVERSE TRANSCRIPTASE
Descriptor:POL protein
Authors:Galilee, M., Alian, A.
Deposit date:2017-08-29
Release date:2018-01-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.942 Å)
Cite:The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance.
PLoS Pathog., 14, 2018
6EX9
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CRYSTAL STRUCTURE OF HIV-1 INTEGRASE CATALYTIC CORE DOMAIN WITH INHIBITOR PEPTIDE
Descriptor:Integrase, Inhibitor Peptide
Authors:Galilee, M., Alian, A.
Deposit date:2017-11-07
Release date:2018-06-06
Method:X-RAY DIFFRACTION (2.014 Å)
Cite:Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms
Biorxiv, 2018
4LAB
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF RLUB
Descriptor:Ribosomal large subunit pseudouridine synthase B, PLATINUM (II) ION, CHLORIDE ION
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-06-19
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5043 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014
4LGT
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF RLUB IN COMPLEX WITH A 21-NUCLEOTIDE RNA SUBSTRATE
Descriptor:Ribosomal large subunit pseudouridine synthase B, stem-loop of 23S rRNA
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-06-28
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014