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5JCT
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BU of 5jct by Molmil
Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24
Descriptor: DIMETHYL SULFOXIDE, FE (III) ION, GLYCEROL, ...
Authors:Ali, S, van Montfort, R.
Deposit date:2016-04-15
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
J. Med. Chem., 60, 2017
5AMV
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BU of 5amv by Molmil
Structural insights into the loss of catalytic competence in pectate lyase at low pH
Descriptor: ACETATE ION, CALCIUM ION, GLYCEROL, ...
Authors:Teixeira, S.C.M, Ali, S, Sondergaard, C, Pickersgill, R.
Deposit date:2015-09-02
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structural Insights Into the Loss of Catalytic Competence in Pectate Lyase Activity at Low Ph.
FEBS Lett., 589, 2015
6H1H
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BU of 6h1h by Molmil
Crystal structure of human Pirin in complex with compound 7 (PLX4720)
Descriptor: 1,2-ETHANEDIOL, FE (III) ION, GLYCEROL, ...
Authors:Ali, S, Le Bihan, Y.V, van Montfort, R.L.M.
Deposit date:2018-07-11
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
6H1I
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BU of 6h1i by Molmil
Crystal structure of human Pirin in complex with bisamide compound 2
Descriptor: FE (III) ION, GLYCEROL, Pirin, ...
Authors:Ali, S, Le Bihan, Y.V, van Montfort, R.L.M.
Deposit date:2018-07-11
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
8PLZ
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BU of 8plz by Molmil
Cryo-EM structure of CAK in complex with inhibitor CT7030
Descriptor: (3~{R},4~{R})-4-[[[7-[(2-methoxyphenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-06-27
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
1QXO
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BU of 1qxo by Molmil
Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP
Descriptor: 1,2-ETHANEDIOL, 5-[(1-CARBOXYVINYL)OXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, COBALT HEXAMMINE(III), ...
Authors:Maclean, J, Ali, S.
Deposit date:2003-09-08
Release date:2003-12-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction
Structure, 11, 2003
7JJM
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BU of 7jjm by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS
Descriptor: CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
Authors:Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7X54
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BU of 7x54 by Molmil
A CBg-ParM filament with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ParM/StbA family protein
Authors:Koh, A, Ali, S, Robinson, R, Narita, A.
Deposit date:2022-03-04
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over
To Be Published
7X55
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BU of 7x55 by Molmil
A CBg-ParM filament with GTP and a short incubation time
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, ParM/StbA family protein
Authors:Koh, A, Ali, S, Robinson, R, Narita, A.
Deposit date:2022-03-04
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over
To Be Published
7X59
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BU of 7x59 by Molmil
A CBg-ParM filament with GTP or GDPPi
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, ParM/StbA family protein
Authors:Koh, A, Ali, S, Robinson, R, Narita, A.
Deposit date:2022-03-04
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over
To Be Published
7X3H
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BU of 7x3h by Molmil
The structure of Clostridium botulinum ParM in the apo conformation
Descriptor: CBg-ParM triple mutant R204D, K230D and N234D
Authors:Robinson, R.C, Ali, S, Narita, A.
Deposit date:2022-03-01
Release date:2023-03-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of tubulin H393D mutant from Odinarchaeota
To Be Published
7X56
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BU of 7x56 by Molmil
A CBg-ParM filament with ADP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ParM/StbA family protein
Authors:Koh, A, Ali, S, Robinson, R, Narita, A.
Deposit date:2022-03-04
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A new actin-like filament from Clostridium botulinum exhibits a new system of filament turn over
To Be Published
7B5O
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BU of 7b5o by Molmil
Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution
Descriptor: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Greber, B.J, Remis, J, Ali, S, Nogales, E.
Deposit date:2020-12-05
Release date:2021-02-10
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:2.5 angstrom -resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942.
Biophys.J., 120, 2021
7B5Q
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BU of 7b5q by Molmil
Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e)
Descriptor: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Greber, B.J, Remis, J, Ali, S, Nogales, E.
Deposit date:2020-12-05
Release date:2021-02-10
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:2.5 angstrom -resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942.
Biophys.J., 120, 2021
7JJL
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BU of 7jjl by Molmil
Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
Descriptor: Importin subunit alpha-3, Lysine-specific histone demethylase 1A
Authors:Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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BU of 7jk7 by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
Descriptor: GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
Authors:Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
8ORM
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BU of 8orm by Molmil
Cryo-EM structure of CAK-THZ1
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-04-14
Release date:2023-08-30
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6V
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BU of 8p6v by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0942
Descriptor: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2023-08-30
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6Y
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BU of 8p6y by Molmil
Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2023-08-30
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P72
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BU of 8p72 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0768
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P71
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BU of 8p71 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0574
Descriptor: (3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P73
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BU of 8p73 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0829
Descriptor: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, CDK-activating kinase assembly factor MAT1, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P79
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BU of 8p79 by Molmil
Cryo-EM structure of CAK with averaged inhibitor density
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (1.7 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P74
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BU of 8p74 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0880 (ring-up conformation)
Descriptor: (2S,3S)-3-[[7-[(2-bromophenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P76
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BU of 8p76 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0914
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
Deposit date:2023-05-30
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2 Å)
Cite:High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024

 

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