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3H9R
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BU of 3h9r by Molmil
Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin
Descriptor: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Chaikuad, A, Alfano, I, Shrestha, B, Muniz, J.R.C, Petrie, K, Fedorov, O, Phillips, C, Bishop, S, Mahajan, P, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2009-04-30
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva.
J.Biol.Chem., 287, 2012
2X7F
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BU of 2x7f by Molmil
Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor
Descriptor: 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION, TRAF2 AND NCK-INTERACTING PROTEIN KINASE
Authors:Vollmar, M, Alfano, I, Shrestha, B, Bray, J, Muniz, J.R.C, Roos, A, Filippakopoulos, P, Burgess-Brown, N, Ugochukwu, E, Gileadi, O, Phillips, C, Mahajan, P, Pike, A.C.W, Fedorov, O, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor
To be Published
4DYM
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BU of 4dym by Molmil
Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
Descriptor: 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, Activin receptor type-1, GLYCEROL, ...
Authors:Chaikuad, A, Sanvitale, C, Cooper, C, Canning, P, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Gileadi, O, Fedorov, O, Krojer, T, Filippakopoulos, P, Muniz, J.R.C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-03-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
To be Published
2JJD
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BU of 2jjd by Molmil
Protein Tyrosine Phosphatase, Receptor Type, E isoform
Descriptor: CHLORIDE ION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON
Authors:Elkins, J.M, Ugochukwu, E, Alfano, I, Barr, A.J, Bunkoczi, G, King, O.N.F, Filippakopoulos, P, Savitsky, P, Salah, E, Pike, A, Johansson, C, Das, S, Burgess-Brown, N.A, Gileadi, O, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3Q4T
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BU of 3q4t by Molmil
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
Descriptor: 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-2A, ...
Authors:Chaikuad, A, Alfano, I, Mahajan, P, Cooper, C.D.O, Sanvitale, C, Vollmar, M, Krojer, T, Muniz, J.R.C, Raynor, J, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-12-24
Release date:2011-02-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
J.Biol.Chem., 290, 2015
3MDY
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BU of 3mdy by Molmil
Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
Descriptor: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A
Authors:Chaikuad, A, Sanvitale, C, Mahajan, P, Daga, N, Cooper, C, Krojer, T, Alfano, I, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-05-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published
3MY0
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BU of 3my0 by Molmil
Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189
Descriptor: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Serine/threonine-protein kinase receptor R3
Authors:Chaikuad, A, Alfano, I, Cooper, C, Mahajan, P, Daga, N, Sanvitale, C, Fedorov, O, Petrie, K, Savitsky, P, Gileadi, O, Sethi, R, Krojer, T, Muniz, J.R.C, Pike, A.C.W, Vollmar, M, Carpenter, C.P, Ugochukwu, E, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-05-08
Release date:2010-07-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Angiogenesis, 18, 2015
3OOM
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BU of 3oom by Molmil
Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
Descriptor: 1,2-ETHANEDIOL, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, Activin receptor type-1, ...
Authors:Chaikuad, A, Sanvitale, C, Cooper, C, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Gileadi, O, Fedorov, O, Allerston, C, Krojer, T, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
2OC3
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BU of 2oc3 by Molmil
Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 18
Descriptor: Tyrosine-protein phosphatase non-receptor type 18
Authors:Ugochukwu, E, Barr, A, Alfano, I, Gorrec, F, Umeano, C, Savitsky, P, Sobott, F, Eswaran, J, Papagrigoriou, E, Debreczeni, J.E, Turnbull, A, Bunkoczi, G, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OOQ
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BU of 2ooq by Molmil
Crystal Structure of the Human Receptor Phosphatase PTPRT
Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Receptor-type tyrosine-protein phosphatase T, ...
Authors:Ugochukwu, E, Alfano, I, Barr, A, Keates, T, Eswaran, J, Salah, E, Savitsky, P, Bunkoczi, G, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-01-26
Release date:2007-02-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2P6X
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BU of 2p6x by Molmil
Crystal structure of human tyrosine phosphatase PTPN22
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 22
Authors:Ugochukwu, E, Salah, E, Barr, A, Shrestha, L, Alfano, I, Burgess-Brown, N, King, O, Umeano, C, Papagrigoriou, E, Pike, A.C.W, Bunkoczi, G, Turnbull, A, Uppenberg, J, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QEP
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BU of 2qep by Molmil
Crystal structure of the D1 domain of PTPRN2 (IA2beta)
Descriptor: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase N2
Authors:Ugochukwu, E, Barr, A, Alfano, I, Berridge, G, Burgess-Brown, N, Das, S, Fedorov, O, King, O, Niesen, F, Watt, S, Savitsky, P, Salah, E, Pike, A.C.W, Bunkoczi, G, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C.H, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3B7O
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BU of 3b7o by Molmil
Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site
Descriptor: D-MALATE, Tyrosine-protein phosphatase non-receptor type 11
Authors:Ugochukwu, E, Barr, A, Patel, A, King, O, Niesen, F, Salah, E, Savitsky, P, Pilka, E.S, Elkins, J, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2GJT
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BU of 2gjt by Molmil
Crystal structure of the human receptor phosphatase PTPRO
Descriptor: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase PTPRO
Authors:Barr, A, Ugochukwu, E, Eswaran, J, Das, S, Niesen, F, Savitsky, P, Turnbull, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, von Delft, F, Papagrigoriou, E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-05-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2H4V
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BU of 2h4v by Molmil
Crystal Structure of the Human Tyrosine Receptor Phosphatase Gamma
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Ugochukwu, E, Barr, A, Das, S, Eswaran, J, Savitsky, P, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Debreczeni, J, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-05-25
Release date:2006-07-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2B49
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BU of 2b49 by Molmil
Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase, non-receptor Type 3
Descriptor: protein tyrosine phosphatase, non-receptor type 3
Authors:Ugochukwu, E, Arrowsmith, C, Barr, A, Bunkoczi, G, Das, S, Debreczeni, J, Edwards, A, Eswaran, J, Knapp, S, Sundstrom, M, Turnbull, A, von Delft, F, Weigelt, J, Structural Genomics Consortium (SGC)
Deposit date:2005-09-23
Release date:2005-10-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2AHS
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BU of 2ahs by Molmil
Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Receptor-type tyrosine-protein phosphatase beta, ...
Authors:Ugochukwu, E, Eswaran, J, Barr, A, Gileadi, O, Sobott, F, Burgess, N, Ball, L, Bray, J, von Delft, F, Debreczeni, J, Bunkoczi, G, Turnbull, A, Das, S, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2005-07-28
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2I75
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BU of 2i75 by Molmil
Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)
Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 4
Authors:Ugochukwu, E, Barr, A, Savitsky, P, Burgess, N, Das, S, Turnbull, A, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-08-30
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CJZ
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BU of 2cjz by Molmil
crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine
Descriptor: 1,2-ETHANEDIOL, HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5, O-PHOSPHOTYROSINE
Authors:Debreczeni, J.E, Barr, A.J, Eswaran, J, Smee, C, Burgess, N, Gileadi, O, Savitsky, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S, von Delft, F.
Deposit date:2006-04-10
Release date:2006-05-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CFV
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BU of 2cfv by Molmil
Crystal structure of human protein tyrosine phosphatase receptor type J
Descriptor: CHLORIDE ION, HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J, NICKEL (II) ION
Authors:Debreczeni, J.E, Barr, A.J, Eswaran, J, Ugochukwu, E, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S.
Deposit date:2006-02-23
Release date:2006-03-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
4NND
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BU of 4nnd by Molmil
Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
Descriptor: Receptor tyrosine-protein kinase erbB-2, Tyrosine-protein phosphatase non-receptor type 18
Authors:Wang, H, Yang, F, Yang, D, Du, Y.
Deposit date:2013-11-17
Release date:2014-11-19
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
To be Published
2NLK
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BU of 2nlk by Molmil
Crystal structure of D1 and D2 catalytic domains of human Protein Tyrosine Phosphatase Gamma (D1+D2 PTPRG)
Descriptor: Protein tyrosine phosphatase, receptor type, G variant (Fragment)
Authors:Filippakopoulos, P, Gileadi, O, Johansson, C, Ugochukwu, E, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-10-20
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2NZ6
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BU of 2nz6 by Molmil
Crystal structure of the PTPRJ inactivating mutant C1239S
Descriptor: CHLORIDE ION, NICKEL (II) ION, PHOSPHATE ION, ...
Authors:Ugochukwu, E, Barr, A, Savitsky, P, Pike, A.C.W, Bunkoczi, G, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-11-22
Release date:2006-12-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2PA5
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BU of 2pa5 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, THIOCYANATE ION, ...
Authors:Ugochukwu, E, Barr, A, Pike, A.C.W, Savitsky, P, Papagrigoriou, E, Turnbull, A, Uppenberg, J, Bunkoczi, G, Salah, E, Das, S, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
4ICZ
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BU of 4icz by Molmil
HER2 1221/1222 phosphorylation regulated by PTPN9
Descriptor: HER2, Tyrosine-protein phosphatase non-receptor type 9
Authors:Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P.
Deposit date:2012-12-11
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:HER2 1221/1222 phosphorylation regulated by PTPN9
To be Published

 

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