Author results

3Q4T
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CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH DORSOMORPHIN
Descriptor:Activin receptor type-2A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, SULFATE ION, ...
Authors:Chaikuad, A., Alfano, I., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Krojer, T., Muniz, J.R.C., Raynor, J., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-12-24
Release date:2011-02-09
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
J.Biol.Chem., 290, 2015
2JJD
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PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON, CHLORIDE ION
Authors:Elkins, J.M., Ugochukwu, E., Alfano, I., Barr, A.J., Bunkoczi, G., King, O.N.F., Filippakopoulos, P., Savitsky, P., Salah, E., Pike, A., Johansson, C., Das, S., Burgess-Brown, N.A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OC3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 18
Descriptor:Tyrosine-protein phosphatase non-receptor type 18
Authors:Ugochukwu, E., Barr, A., Alfano, I., Gorrec, F., Umeano, C., Savitsky, P., Sobott, F., Eswaran, J., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OOQ
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRT
Descriptor:Receptor-type tyrosine-protein phosphatase T, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, ...
Authors:Ugochukwu, E., Alfano, I., Barr, A., Keates, T., Eswaran, J., Salah, E., Savitsky, P., Bunkoczi, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-01-26
Release date:2007-02-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2P6X
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE PTPN22
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
Descriptor:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
Authors:Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2X7F
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK- INTERACTING KINASE WITH WEE1CHK1 INHIBITOR
Descriptor:TRAF2 AND NCK-INTERACTING PROTEIN KINASE, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION
Authors:Vollmar, M., Alfano, I., Shrestha, B., Bray, J., Muniz, J.R.C., Roos, A., Filippakopoulos, P., Burgess-Brown, N., Ugochukwu, E., Gileadi, O., Phillips, C., Mahajan, P., Pike, A.C.W., Fedorov, O., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor
To be Published
3H9R
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF TYPE I ACTIVIN RECEPTOR (ACVR1) IN COMPLEX WITH FKBP12 AND DORSOMORPHIN
Descriptor:Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, ...
Authors:Chaikuad, A., Alfano, I., Shrestha, B., Muniz, J.R.C., Petrie, K., Fedorov, O., Phillips, C., Bishop, S., Mahajan, P., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-04-30
Release date:2009-06-02
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva.
J.Biol.Chem., 287, 2012
3MDY
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN COMPLEX WITH FKBP12 AND LDN-193189
Descriptor:Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Authors:Chaikuad, A., Sanvitale, C., Mahajan, P., Daga, N., Cooper, C., Krojer, T., Alfano, I., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published
3MY0
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CRYSTAL STRUCTURE OF THE ACVRL1 (ALK1) KINASE DOMAIN BOUND TO LDN-193189
Descriptor:Serine/threonine-protein kinase receptor R3, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Authors:Chaikuad, A., Alfano, I., Cooper, C., Mahajan, P., Daga, N., Sanvitale, C., Fedorov, O., Petrie, K., Savitsky, P., Gileadi, O., Sethi, R., Krojer, T., Muniz, J.R.C., Pike, A.C.W., Vollmar, M., Carpenter, C.P., Ugochukwu, E., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-05-08
Release date:2010-07-21
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Angiogenesis, 18, 2015
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
Descriptor:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
4DYM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00135
Descriptor:Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Canning, P., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Krojer, T., Filippakopoulos, P., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
To be Published
2AHS
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE RECEPTOR PHOSPHATASE BETA
Descriptor:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, SODIUM ION, ...
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Gileadi, O., Sobott, F., Burgess, N., Ball, L., Bray, J., von Delft, F., Debreczeni, J., Bunkoczi, G., Turnbull, A., Das, S., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-28
Release date:2005-08-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2B49
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 3
Descriptor:protein tyrosine phosphatase, non-receptor type 3
Authors:Ugochukwu, E., Arrowsmith, C., Barr, A., Bunkoczi, G., Das, S., Debreczeni, J., Edwards, A., Eswaran, J., Knapp, S., Sundstrom, M., Turnbull, A., von Delft, F., Weigelt, J., Structural Genomics Consortium (SGC)
Deposit date:2005-09-23
Release date:2005-10-04
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CFV
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J
Descriptor:HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J, NICKEL (II) ION, CHLORIDE ION
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Ugochukwu, E., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2006-02-23
Release date:2006-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CJZ
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CRYSTAL STRUCTURE OF THE C472S MUTANT OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED PHOSPHATASE) IN COMPLEX WITH PHOSPHOTYROSINE
Descriptor:HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5, O-PHOSPHOTYROSINE, 1,2-ETHANEDIOL
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Savitsky, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S., von Delft, F.
Deposit date:2006-04-10
Release date:2006-05-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2GJT
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRO
Descriptor:Receptor-type tyrosine-protein phosphatase PTPRO, CHLORIDE ION
Authors:Barr, A., Ugochukwu, E., Eswaran, J., Das, S., Niesen, F., Savitsky, P., Turnbull, A., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., von Delft, F., Papagrigoriou, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-05-02
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2H4V
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE RECEPTOR PHOSPHATASE GAMMA
Descriptor:Receptor-type tyrosine-protein phosphatase gamma, CHLORIDE ION, CITRATE ANION, ...
Authors:Ugochukwu, E., Barr, A., Das, S., Eswaran, J., Savitsky, P., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Debreczeni, J., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-25
Release date:2006-07-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2I75
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE N4 (PTPN4)
Descriptor:Tyrosine-protein phosphatase non-receptor type 4, SULFATE ION
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Burgess, N., Das, S., Turnbull, A., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-08-30
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2NLK
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CRYSTAL STRUCTURE OF D1 AND D2 CATALYTIC DOMAINS OF HUMAN PROTEIN TYROSINE PHOSPHATASE GAMMA (D1+D2 PTPRG)
Descriptor:Protein tyrosine phosphatase, receptor type, G variant (Fragment)
Authors:Filippakopoulos, P., Gileadi, O., Johansson, C., Ugochukwu, E., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-10-20
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2NZ6
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CRYSTAL STRUCTURE OF THE PTPRJ INACTIVATING MUTANT C1239S
Descriptor:Receptor-type tyrosine-protein phosphatase eta, NICKEL (II) ION, PHOSPHATE ION, ...
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Pike, A.C.W., Bunkoczi, G., Sundstrom, M., Weigelt, J., Arrowsmith, C.H., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-22
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2PA5
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9
Descriptor:Tyrosine-protein phosphatase non-receptor type 9, CHLORIDE ION, THIOCYANATE ION, ...
Authors:Ugochukwu, E., Barr, A., Pike, A.C.W., Savitsky, P., Papagrigoriou, E., Turnbull, A., Uppenberg, J., Bunkoczi, G., Salah, E., Das, S., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3B7O
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE PHOSPHATASE SHP2 (PTPN11) WITH AN ACCESSIBLE ACTIVE SITE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, D-MALATE
Authors:Ugochukwu, E., Barr, A., Patel, A., King, O., Niesen, F., Salah, E., Savitsky, P., Pilka, E.S., Elkins, J., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3MTF
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE IN COMPLEX WITH A 2-AMINOPYRIDINE INHIBITOR
Descriptor:Activin receptor type-1, PHOSPHATE ION, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Canning, P., Krojer, T., Vollmar, M., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-23
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A new class of small molecule inhibitor of BMP signaling.
Plos One, 8, 2013
3MXO
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CRYSTAL STRUCTURE OH HUMAN PHOSPHOGLYCERATE MUTASE FAMILY MEMBER 5 (PGAM5)
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Alfano, I., Picaud, S., Filippakopoulos, P., Barr, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-05-07
Release date:2010-09-15
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Structure, 2017
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