Author results

1D4L
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HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
Descriptor:HIV-1 PROTEASE, SULFATE ION, (10S,13S,1'R)-13-[1'-HYDROXY-2'-(N-P-AMINOBENZENESULFONYL-1''-AMINO-3''-METHYLBUTYL)ETHYL]-8,11-DIOXO-10-ISOPROPYL-2-OXA-9,12-DIAZABICYCLO [13.2.2]NONADECA-15,17,18-TRIENE
Authors:Tyndall, J.D., Reid, R.C., Tyssen, D.P., Jardine, D.K., Todd, B., Passmore, M., March, D.R., Pattenden, L.K., Alewood, D., Hu, S.H., Alewood, P.F., Birch, C.J., Martin, J.L., Fairlie, D.P.
Deposit date:1999-10-04
Release date:2000-10-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
J.Med.Chem., 43, 2000
1D4K
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HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
Descriptor:HIV-1 PROTEASE, SULFATE ION, N-13-[(10S,13S)-9,12-DIOXO-10-(2-BUTYL)-2-OXA-8,11-DIAZABICYCLO [13.2.2] NONADECA-15,17,18-TRIENE] (2R)-BENZYL-(4S)-HYDROXY-5-AMINOPENTANOIC (1R)-HYDROXY-(2S)-INDANEAMIDE
Authors:Tyndall, J.D., Reid, R.C., Tyssen, D.P., Jardine, D.K., Todd, B., Passmore, M., March, D.R., Pattenden, L.K., Alewood, D., Hu, S.H., Alewood, P.F., Birch, C.J., Martin, J.L., Fairlie, D.P.
Deposit date:1999-10-04
Release date:2000-10-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
J.Med.Chem., 43, 2000
3BXR
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CRYSTAL STRUCTURES OF HIGHLY CONSTRAINED SUBSTRATE AND HYDROLYSIS PRODUCTS BOUND TO HIV-1 PROTEASE. IMPLICATIONS FOR CATALYTIC MECHANISM
Descriptor:Protease, SULFATE ION, (9S,12S)-9-(1-methylethyl)-N-[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]-7,10-dioxo-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-12-carboxamide
Authors:Tyndall, J.D., Pattenden, L.K., Reid, R.C., Hu, S.H., Alewood, D., Alewood, P.F., Walsh, T., Fairlie, D.P., Martin, J.L.
Deposit date:2008-01-14
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism
Biochemistry, 47, 2008
3BXS
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CRYSTAL STRUCTURES OF HIGHLY CONSTRAINED SUBSTRATE AND HYDROLYSIS PRODUCTS BOUND TO HIV-1 PROTEASE. IMPLICATIONS FOR CATALYTIC MECHANISM
Descriptor:Protease, SULFATE ION, (9S,12S)-9-(1-methylethyl)-7,10-dioxo-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-12-carboxylic acid
Authors:Tyndall, J.D., Pattenden, L.K., Reid, R.C., Hu, S.H., Alewood, D., Alewood, P.F., Walsh, T., Fairlie, D.P., Martin, J.L.
Deposit date:2008-01-14
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism
Biochemistry, 47, 2008
1A3P
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ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES
Descriptor:EPIDERMAL GROWTH FACTOR
Authors:Barnham, K., Torres, A., Alewood, D., Alewood, P., Domagala, T., Nice, E., Norton, R.
Deposit date:1998-01-22
Release date:1998-07-29
Last modified:2018-03-14
Method:SOLUTION NMR
Cite:Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Protein Sci., 7, 1998
1B6J
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
Descriptor:RETROPEPSIN, CYCLIC PEPTIDE INHIBITOR, SULFATE ION
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6K
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
Descriptor:RETROPEPSIN, SULFATE ION, N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2]HEPTADECA-1(16),13(17),14- TRIEN-11-YLAMINO)-2-HYDROXY-1-(4-HYDROXY-BENZYL)-PROPYL]-3-METHYL-2- (2-OXO-PYRROLIDIN-1-YL)-BUTYRAMIDE
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6L
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
Descriptor:RETROPEPSIN, SULFATE ION, 1-[2-(8-CARBAMOYLMETHYL-6,9-DIOXO-2-OXA-7,10-DIAZA-BICYCLO[11.2.2]HEPTADECA- 1(16),13(17),14-TRIEN-11-YL)-2-HYDROXY-ETHYL]-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYLAMIDE
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6M
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
Descriptor:RETROPEPSIN, SULFATE ION, [1-BENZYL-3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YLAMINO)-2-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6P
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
Descriptor:RETROPEPSIN, SULFATE ION, N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YAMINO)-2-HYDROXY-1-(4-HYDROXY-BENZYL) -PROPYL]-3-METHYL-2-PROPIONYLAMINO-BUTYRAMIDE
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B8W
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DEFENSIN-LIKE PEPTIDE 1
Descriptor:PROTEIN (DEFENSIN-LIKE PEPTIDE 1)
Authors:Torres, A.M., Wang, X., Fletcher, J.I., Alewood, D., Alewood, P.F., Smith, R., Simpson, R.J., Nicholson, G.M., Sutherland, S.K., Gallagher, C.H., King, G.F., Kuchel, P.W.
Deposit date:1999-02-02
Release date:1999-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a defensin-like peptide from platypus venom.
Biochem.J., 341, 1999
1QDP
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SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES
Descriptor:ROBUSTOXIN
Authors:Pallaghy, P.K., Alewood, D., Alewood, P.F., Norton, R.S.
Deposit date:1997-10-09
Release date:1998-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus.
FEBS Lett., 419, 1997
1Z1H
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 3
Descriptor:Pol polyprotein, SULFATE ION, N-{(2R)-2-HYDROXY-2-[(8S,11S)-8-ISOPROPYL-6,9-DIOXO-2-OXA-7,10-DIAZABICYCLO[11.2.2]HEPTADECA-1(15),13,16-TRIEN-11-YL]ETHYL}-N-ISOPENTYLBENZENESULFONAMIDE
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:2005-03-04
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease
Biochemistry, 38, 1999
1Z1R
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HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 2
Descriptor:Pol polyprotein, SULFATE ION, 2-[(8S,11S)-11-{(1R)-1-HYDROXY-2-[ISOPENTYL(PHENYLSULFONYL)AMINO]ETHYL}-6,9-DIOXO-2-OXA-7,10-DIAZABICYCLO[11.2.2]HEPTADECA-1(15),13,16-TRIEN-8-YL]ACETAMIDE
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:2005-03-06
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease
Biochemistry, 38, 1999
2LET
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AN 1H NMR DETERMINATION OF THE THREE DIMENSIONAL STRUCTURES OF MIRROR IMAGE FORMS OF A LEU-5 VARIANT OF THE TRYPSIN INHIBITOR ECBALLIUM ELATERIUM (EETI-II)
Descriptor:TRYPSIN INHIBITOR II
Authors:Nielsen, K.J., Alewood, D., Andrews, J., Kent, S.B.H., Craik, D.J.
Deposit date:1994-01-04
Release date:1994-05-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:An 1H NMR determination of the three-dimensional structures of mirror-image forms of a Leu-5 variant of the trypsin inhibitor from Ecballium elaterium (EETI-II).
Protein Sci., 3, 1994
1D6B
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SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM
Descriptor:DEFENSIN-LIKE PEPTIDE-2
Authors:Torres, A.M., De Plater, G.M., Doverskog, M., C Birinyi-Strachan, L., Nicholson, G.M., Gallagher, C.H., Kuchel, P.W.
Deposit date:1999-10-12
Release date:2000-06-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold.
Biochem.J., 348, 2000