Author results

6I6C
  • Download 6i6c
  • View 6i6c
Molmil generated image of 6i6c
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl)sulfonylbicyclo[2.2.1]heptane-2-carboxamide, ...
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-15
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
6I6F
  • Download 6i6f
  • View 6i6f
Molmil generated image of 6i6f
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 1
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ethyl 4-azanyl-3-bromanyl-benzoate, ...
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-15
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
6I6P
  • Download 6i6p
  • View 6i6p
Molmil generated image of 6i6p
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 3
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-azaspiro[3.4]octan-6-yl-[2,4-bis(chloranyl)-6-oxidanyl-phenyl]methanone, ...
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-15
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
6I6T
  • Download 6i6t
  • View 6i6t
Molmil generated image of 6i6t
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 5
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-bromanyl-1-oxidanyl-naphthalene-2-carboxylic acid, ...
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-15
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
6I6V
  • Download 6i6v
  • View 6i6v
Molmil generated image of 6i6v
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 6
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[[(3~{R})-oxan-3-yl]methylsulfonyl]-2-azaspiro[4.5]decane, ...
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-15
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
6I79
  • Download 6i79
  • View 6i79
Molmil generated image of 6i79
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 4
Descriptor:Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-[(4-~{tert}-butyl-1,3-thiazol-2-yl)methyl]-4,6-diazaspiro[2.4]heptane-5,7-dione
Authors:Alen, J., Schade, M., Wagener, M., Blaesse, M.
Deposit date:2018-11-16
Release date:2019-07-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
J.Med.Chem., 62, 2019
4WOT
  • Download 4wot
  • View 4wot
Molmil generated image of 4wot
ROCK2 IN COMPLEX WITH 1426382-07-1
Descriptor:Rho-associated protein kinase 2, methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate
Authors:Augustin, M., Krapp, S., Boland, S., Defert, O., Bourin, A., Alen, J., Leysen, D.
Deposit date:2014-10-16
Release date:2015-05-06
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.
J. Med. Chem., 58, 2015