Author results

5M50
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MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
分子名称:Tubulin alpha chain, Tubulin beta-2B chain, Calmodulin-regulated spectrin-associated protein 3, ...
著者Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-P., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
登録日2016-10-20
公開日2017-10-04
最終更新日2017-11-15
実験手法ELECTRON MICROSCOPY (5.3 Å)
主引用文献A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5M54
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MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
分子名称:Calmodulin-regulated spectrin-associated protein 1, Tubulin alpha chain, Tubulin beta-2B chain, ...
著者Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-J., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
登録日2016-10-20
公開日2017-10-04
最終更新日2017-11-15
実験手法ELECTRON MICROSCOPY (8 Å)
主引用文献A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5M5C
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MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
分子名称:Calmodulin-regulated spectrin-associated protein 1, Tubulin alpha chain, Tubulin beta-2B chain, ...
著者Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-P., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
登録日2016-10-21
公開日2017-10-04
最終更新日2017-11-15
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5JH7
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TUBULIN-ERIBULIN COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Doodhi, H., Prota, A.E., Rodriguez-Garcia, R., Xiao, H., Custar, D.W., Bargsten, K., Katrukha, E.A., Hilbert, M., Hua, S., Jiang, K., Grigoriev, I., Yang, C.-P.H., Cox, D., Band Horwitz, S., Kapitein, L.C., Akhmanova, A., Steinmetz, M.O.
登録日2016-04-20
公開日2016-06-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Curr.Biol., 26, 2016
5NBT
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APO STRUCTURE OF P60N/P80C KATANIN
分子名称:Katanin p80 WD40 repeat-containing subunit B1, Katanin p60 ATPase-containing subunit A1
著者Jiang, K., Rezabkova, L., Hua, S., Liu, Q., Capitani, G., Altelaar, A.F.M., Heck, A.J.R., Kammerer, R.A., Steinmetz, M.O., Akhmanova, A.
登録日2017-03-02
公開日2017-04-26
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Nat. Cell Biol., 19, 2017
5ITZ
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CRYSTAL STRUCTURE OF THE SAC DOMAIN OF CPAP IN A COMPLEX WITH TUBULIN AND DARPIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Centromere protein J, ...
著者Sharma, A., Steinmetz, M.O.
登録日2016-03-17
公開日2016-06-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.
Dev.Cell, 37, 2016
5N74
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MICROTUBULE END BINDING PROTEIN COMPLEX
分子名称:Uncharacterized protein, GLY-SER-THR-ARG-ARG-ARG-THR-ARG-LEU-ARG-PRO-PRO-THR-PRO-LEU-SER-GLN-LEU-LEU-SER-PRO
著者Kumar, A., Steinmetz, M.
登録日2017-02-18
公開日2017-06-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.
Structure, 25, 2017
5NR4
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CRYSTAL STRUCTURE OF CLASP2 TOG1 DOMAIN
分子名称:CLIP-associating protein 2
著者Sharma, A., Olieric, N., Weinert, T., Olieric, V., Steinmetz, M.O.
登録日2017-04-21
公開日2018-05-30
最終更新日2018-07-18
実験手法X-RAY DIFFRACTION (1.198 Å)
主引用文献CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Dev. Cell, 46, 2018
3E2U
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CRYSTAL STRUCTURE OF THE ZINK-KNUCKLE 2 DOMAIN OF HUMAN CLIP-170 IN COMPLEX WITH CAP-GLY DOMAIN OF HUMAN DYNACTIN-1 (P150-GLUED)
分子名称:Dynactin subunit 1, CAP-Gly domain-containing linker protein 1, ZINC ION
著者Weisbrich, A., Honnappa, S., Capitani, G., Steinmetz, M.O.
登録日2008-08-06
公開日2008-08-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-function relationship of CAP-Gly domains
Nat.Struct.Mol.Biol., 14, 2007
3GJO
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CRYSTAL STRUCTURE OF HUMAN EB1 IN COMPLEX WITH MICROTUBULE TIP LOCALIZATION SIGNAL PEPTIDE OF MACF
分子名称:Microtubule-associated protein RP/EB family member 1, Dystonin
著者Honnappa, S., Steinmetz, M.O.
登録日2009-03-09
公開日2009-08-04
最終更新日2012-04-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An EB1-binding motif acts as a microtubule tip localization signal
Cell(Cambridge,Mass.), 138, 2009
5JHA
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN2
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
著者Burke, J.E., Inglis, A.J., Williams, R.L.
登録日2016-04-20
公開日2017-03-15
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5JHB
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN3
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
著者Burke, J.E., Inglis, A.J., Williams, R.L.
登録日2016-04-20
公開日2017-03-15
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5M7E
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TUBULIN-BKM120 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Bohnacker, T., Prota, A.E., Steinmetz, M.O., Wymann, M.P.
登録日2016-10-27
公開日2017-02-22
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.046 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5M7G
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TUBULIN-MTD147 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Bohnacker, T., Prota, A.E., Steinmetz, M.O., Wymann, M.P.
登録日2016-10-27
公開日2017-02-22
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5M8D
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TUBULIN MTD265-R1 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Bohnacker, T., Prota, A.E., Steinmetz, M.O., Wymann, M.P.
登録日2016-10-28
公開日2017-03-22
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5M8G
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TUBULIN-MTD265 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Bohnacker, T., Prota, A.E., Steinmetz, M.O., Wymann, M.P.
登録日2016-10-28
公開日2017-02-22
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.147 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5OV7
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TUBULIN - RIGOSERTIB COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Menchon, G., Prota, A.E., Steinmetz, M., Jost, M.
登録日2017-08-28
公開日2017-10-11
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
Mol. Cell, 68, 2017
3CO1
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CRYSTAL STRUCTURE OF MICROTUBULE BINDING DOMAIN OF HUMAN EB3
分子名称:Microtubule-associated protein RP/EB family member 3
著者De Groot, C.O., Honnappa, S., Steinmetz, M.O.
登録日2008-03-27
公開日2009-03-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Mammalian end binding proteins control persistent microtubule growth.
J.Cell Biol., 2009
3RDV
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STRUCTURE OF THE SLAIN2C-CLIPCG1 COMPLEX
分子名称:CAP-Gly domain-containing linker protein 1, SLAIN motif-containing protein 2, SODIUM ION, ...
著者Manatschal, C., Olieric, V., Steinmetz, M.O.
登録日2011-04-01
公開日2011-06-29
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase
J.Cell Biol., 193, 2011
5JO8
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CEP104 TOG DOMAIN
分子名称:CEP104
著者Rezabkova, L., Kraatz, S.H.W.
登録日2016-05-02
公開日2016-07-20
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.
J.Biol.Chem., 291, 2016
5LB7
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COMPLEX STRUCTURE BETWEEN P60N/P80C KATANIN AND A PEPTIDE DERIVED FROM ASPM
分子名称:Katanin p80 WD40 repeat-containing subunit B1, Katanin p60 ATPase-containing subunit A1, Abnormal spindle-like microcephaly-associated protein homolog
著者Rezabkova, L., Capitani, G., Kammerer, R.A., Steinmetz, M.O.
登録日2016-06-15
公開日2017-04-26
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Nat. Cell Biol., 19, 2017
5LZN
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-TIP MICROTUBULE-BINDING DOMAIN
分子名称:Calmodulin-regulated spectrin-associated protein 3
著者Stangier, M.M., Steinmetz, M.O.
登録日2016-09-30
公開日2017-10-04
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5OW5
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P60P80-CAMSAP COMPLEX
分子名称:Katanin p80 WD40 repeat-containing subunit B1, Katanin p60 ATPase-containing subunit A1, Calmodulin-regulated spectrin-associated protein, ...
著者Rezabkova, L., Capitani, G., Prota, A.E., Kammerer, R.A., Steinmetz, M.O.
登録日2017-08-30
公開日2018-07-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.
Structure, 26, 2018