Author results

4V3K
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RNF38-UBCH5B-UB COMPLEX
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3L
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RNF38-UB-UBCH5B-UB COMPLEX
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4UNO
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 5, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ...
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., Shrestha, L., Burgess-Brown, N., Kopec, J., Fitzpatrick, F., Tallant, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2014-05-29
Release date:2014-06-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4V0P
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CRYSTAL STRUCTURE OF THE MAGE HOMOLOGY DOMAIN OF HUMAN MAGE-A3
Descriptor:MELANOMA-ASSOCIATED ANTIGEN 3
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2014-09-17
Release date:2014-10-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
5A9F
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA IN COMPLEX WITH ADP
Descriptor:DNA POLYMERASE THETA, ADENOSINE-5'-DIPHOSPHATE, POTASSIUM ION, ...
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-07-21
Release date:2015-12-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5A9J
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA, APO-FORM
Descriptor:DNA POLYMERASE THETA
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-07-21
Release date:2015-12-16
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5AGA
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA IN COMPLEX WITH AMPPNP
Descriptor:DNA POLYMERASE THETA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CITRATE ANION, ...
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-01-29
Release date:2015-02-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5HVQ
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ALTERNATIVE MODEL OF THE MAGE-G1 NSE-1 COMPLEX
Descriptor:Melanoma-associated antigen G1, Non-structural maintenance of chromosomes element 1 homolog, ZINC ION
Authors:Newman, J.A., Cooper, C.D.O., Roos, A.K., Aitkenhead, H., Oppermann, U.C.T., Cho, H.J., Osman, R., Gileadi, O.
Deposit date:2016-01-28
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.923 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
5LB3
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH ADP/MG.
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LB5
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH ADP/MG (TRICILINC FORM).
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LB8
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE APO FORM.
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LBA
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH DSPL FRAGMENT(1-CYCLOHEXYL-3-(OXOLAN-2-YLMETHYL)UREA, SGC - DIAMOND XCHEM I04-1 FRAGMENT SCREENING.
Descriptor:ATP-dependent DNA helicase Q5, MAGNESIUM ION, ZINC ION, ...
Authors:Newman, J.A., Aitkenhead, H., Talon, R., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea)
To be published
5MR1
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CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF INTERACTOR PROTEIN FOR CYTOHESIN EXCHANGE FACTORS 1 (IPCEF1)
Descriptor:Interactor protein for cytohesin exchange factors 1
Authors:Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N., Williams, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2016-12-21
Release date:2017-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
To be published
5NZW
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFTRIAXONE
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, Ceftriaxone
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxone
To Be Published
5NZX
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFTRIAXONE (ALTERNATIVE SITE)
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, Ceftriaxone
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with Ceftriaxone (alternative site)
To Be Published
5NZY
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFOTAXIME
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:To Be published
To Be Published
5OCN
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CRYSTAL STRUCTURE OF THE FORKHEAD DOMAIN OF HUMAN FOXN1
Descriptor:Forkhead box protein N1, POTASSIUM ION
Authors:Newman, J.A., Aitkenhead, H., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-07-03
Release date:2017-08-02
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the forkhead domain of human FOXN1
To be published
5Q1J
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMSOA000341B
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1K
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000074A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1L
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000073A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1M
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000740A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1N
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000295A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1O
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000478A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1P
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000299A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:PanDDA analysis group deposition
To Be Published
5Q1Q
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMOPL000294A
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:PanDDA analysis group deposition
To Be Published