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1H35
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4'-{[ALLYL(METHYL)AMINO]METHYL}-1,1'-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H36
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, {4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CYCLOPROPYL)METHOXY]PHENYL}(4-BROMOPHENYL)METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H39
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3A
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3B
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SQUALENE-HOPENE CYCLASE
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-25
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3C
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-25
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6H
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SQUALENE-HOPENE CYCLASE
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-10-03
公開日2003-10-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6Q
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{4-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-BUT-2-ENYL}-METHYL-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-10-13
公開日2003-10-17
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O6R
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-HEXYL-}-METHYL-AMIN
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-10-13
公開日2003-10-17
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1O79
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STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, METHYL-[4-(4-PIPERIDINE-1-YLMETHYL-PHENYL)-CYCLOHEXYL]-CARBAMINIC ACID-(4-CHLOROPHENYL)-ESTER
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-10-27
公開日2003-10-23
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1Y8J
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CRYSTAL STRUCTURE OF HUMAN NEP COMPLEXED WITH AN IMIDAZO[4,5-C]PYRIDINE INHIBITOR
分子名称:Neprilysin, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
著者Sahli, S., Frank, B., Schweizer, W.B., Diederich, F., Blum-Kaelin, D., Aebi, J.D., Bohm, H.J., Oefner, C., Dale, G.E.
登録日2004-12-13
公開日2005-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis
HELV.CHIM.ACTA, 88, 2005
4ZGX
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STRUCTURE OF ALDOSTERONE SYNTHASE (CYP11B2) IN COMPLEX WITH (+)-(R)-N-(4-(4-CHLORO-3-FLUOROPHENYL)-5,6,7,8-TETRAHYDROISOQUINOLIN-8-YL)PROPIONAMIDE
分子名称:Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Kuglstatter, A., Joseph, C.
登録日2015-04-24
公開日2015-10-07
最終更新日2015-11-04
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
J.Med.Chem., 58, 2015
1GSZ
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CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE
著者Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E.
登録日2002-01-09
公開日2003-01-16
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Chem.Biol., 9, 2002