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4WQ2
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BU of 4wq2 by Molmil
Human calpain PEF(S) with (Z)-3-(6-bromondol-3-yl)-2-mercaptoacrylic acid bound
Descriptor: (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Adams, S.E, Rizkallah, P.J, Miller, D.J, Hallett, M.B, Allemann, R.K.
Deposit date:2014-10-21
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
4WQ3
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BU of 4wq3 by Molmil
Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-bromoindol-3-yl)acrylic acid) bound
Descriptor: (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, CALCIUM ION, Calpain small subunit 1
Authors:Adams, S.E, Robinson, E.J, Rizkallah, P.J, Miller, D.J, Hallett, M.B, Allemann, R.K.
Deposit date:2014-10-21
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
5D69
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BU of 5d69 by Molmil
Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound
Descriptor: (2E,2'Z)-2,2'-disulfanediylbis[3-(4-iodophenyl)prop-2-enoic acid], CALCIUM ION, Calpain small subunit 1, ...
Authors:Adams, S.E, Robinson, E.J, Rizkallah, P.J, Miller, D.J, Hallett, M.B, Allemann, R.K.
Deposit date:2015-08-11
Release date:2015-09-02
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
7AB8
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BU of 7ab8 by Molmil
Crystal structure of a GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-09-07
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AML
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BU of 7aml by Molmil
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-10-09
Release date:2021-01-13
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
4PHJ
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BU of 4phj by Molmil
The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids: Human unliganded protein
Descriptor: CALCIUM ION, Calpain small subunit 1
Authors:Adams, S.E, Rizkallah, P.J, Allemann, R.K, Miller, D.J, Hallett, M.B, Robinson, E.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
4PHM
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BU of 4phm by Molmil
The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids
Descriptor: 3-(5-bromo-1H-indol-3-yl)-2-thioxopropanoic acid, CALCIUM ION, Calpain small subunit 1
Authors:Rizkallah, P.J, Allemann, R.K, Adams, S.E, Miller, D.J, Hallett, M.B.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
4PHK
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BU of 4phk by Molmil
The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid
Descriptor: (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid, CALCIUM ION, Calpain small subunit 1
Authors:Rizkallah, P.J, Allemann, R.K, Adams, S.E, Miller, D.J, Hallett, M.B, Robinson, E.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
4PHN
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BU of 4phn by Molmil
The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids
Descriptor: CALCIUM ION, Calpain small subunit 1
Authors:Allemann, R.K, Rizkallah, P.J, Adams, S.E, Miller, D.J, Hallett, M.B.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
1CSZ
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BU of 1csz by Molmil
SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE
Authors:Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CSY
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BU of 1csy by Molmil
SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE
Authors:Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1EYM
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BU of 1eym by Molmil
FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX
Descriptor: FK506 BINDING PROTEIN
Authors:Rollins, C.T, Rivera, V.M, Woolfson, D.N, Keenan, T, Hatada, M, Adams, S.E, Andrade, L.J, Yaeger, D, van Schravendijk, M.R, Holt, D.A, Gilman, M, Clackson, T.
Deposit date:2000-05-07
Release date:2000-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
8OS6
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BU of 8os6 by Molmil
Structure of a GFRA1/GDNF LICAM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Houghton, F.M, Adams, S.E, Briggs, D.C, McDonald, N.Q.
Deposit date:2023-04-18
Release date:2023-11-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Architecture and regulation of a GDNF-GFR alpha 1 synaptic adhesion assembly.
Nat Commun, 14, 2023
7AMK
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BU of 7amk by Molmil
Zebrafish RET Cadherin Like Domains 1 to 4.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Purkiss, A.G, McDonald, N.Q, Goodman, K.M, Narowtek, A, Knowles, P.P.
Deposit date:2020-10-09
Release date:2021-02-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7NAL
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BU of 7nal by Molmil
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1
Authors:Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAK
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BU of 7nak by Molmil
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)
Descriptor: NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAJ
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BU of 7naj by Molmil
Crystal structure of the TIR domain from human SARM1 in complex with ara-2'F-ADPR
Descriptor: 1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-D-arabinitol, Sterile alpha and TIR motif-containing protein 1
Authors:Shi, Y, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAG
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BU of 7nag by Molmil
Crystal structure of the TIR domain from human SARM1 in complex with 1AD
Descriptor: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Shi, Y, Bosanac, T, Hughes, R.O, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAH
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BU of 7nah by Molmil
Crystal structure of the TIR domain from human SARM1 in complex with 2AD
Descriptor: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(8-oxidanylidene-7~{H}-2,7-naphthyridin-2-yl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Shi, Y, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAI
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BU of 7nai by Molmil
Crystal structure of the TIR domain from human SARM1 in complex with 3AD
Descriptor: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Shi, Y, Ve, T.
Deposit date:2021-06-21
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022

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