Author results

4LAJ
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CRYSTAL STRUCTURE OF HIV-1 YU2 ENVELOPE GP120 GLYCOPROTEIN IN COMPLEX WITH CD4-MIMETIC MINIPROTEIN, M48U1, AND LLAMA SINGLE-DOMAIN, BROADLY NEUTRALIZING, CO-RECEPTOR BINDING SITE ANTIBODY, JM4
Descriptor:HIV-1 YU2 gp120 envelope glycoprotein, CD4-mimetic miniprotein M48U1, Llama single domain antibody, ...
Authors:Acharya, P., Luongo, T.S., Kwong, P.D.
Deposit date:2013-06-20
Release date:2013-08-14
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites.
J.Virol., 87, 2013
4JZW
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U1 IN COMPLEX WITH HIV-1 YU2 GP120 IN P212121 SPACE GROUP
Descriptor:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2013-04-03
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.784 Å)
Cite:Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
4JZZ
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U1 IN COMPLEX WITH HIV-1 YU2 GP120 IN C2221 SPACE GROUP
Descriptor:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2013-04-03
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
4K0A
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U7 IN COMPLEX WITH HIV-1 YU2 GP120
Descriptor:HIV-1 YU2 gp120 glycoprotein, CD4-MIMETIC MINIPROTEIN M48U7, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2013-04-03
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
1Y5Y
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STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AM1
Descriptor:Formaldehyde-activating enzyme fae, CALCIUM ION, SODIUM ION
Authors:Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K., Ermler, U.
Deposit date:2004-12-03
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:How an enzyme binds the C1-carrier tetrahydromethanopterin: Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1
J.Biol.Chem., 280, 2005
1Y60
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STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AM1 WITH BOUND 5,10-METHYLENE TETRAHYDROMETHANOPTERIN
Descriptor:Formaldehyde-activating enzyme fae, 5,10-DIMETHYLENE TETRAHYDROMETHANOPTERIN
Authors:Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K., Ermler, U.
Deposit date:2004-12-03
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:How an enzyme binds the C1-carrier tetrahydromethanopterin: Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1
J.Biol.Chem., 280, 2005
2FHJ
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CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES
Descriptor:Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION, N-[4,5,7-TRICARBOXYHEPTANOYL]-L-GAMMA-GLUTAMYL-N-{2-[4-({5-[(FORMYLAMINO)METHYL]-3-FURYL}METHOXY)PHENYL]ETHYL}-D-GLUTAMINE, ...
Authors:Acharya, P., Warkentin, E., Thauer, R.K., Shima, S., Ermler, U.
Deposit date:2005-12-25
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
J.Mol.Biol., 357, 2006
2FHK
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CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES
Descriptor:Formylmethanofuran--tetrahydromethanopterin formyltransferase, POTASSIUM ION, N-[4,5,7-TRICARBOXYHEPTANOYL]-L-GAMMA-GLUTAMYL-N-{2-[4-({5-[(FORMYLAMINO)METHYL]-3-FURYL}METHOXY)PHENYL]ETHYL}-D-GLUTAMINE
Authors:Acharya, P., Warkentin, E., Thauer, R.K., Shima, S., Ermler, U.
Deposit date:2005-12-25
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
J.Mol.Biol., 357, 2006
4R4F
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING, A32-LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV-1 YU2 GP120
Descriptor:HIV-1 Env gp120, Antibody 2.2c LIGHT CHAIN, Antibody 2.2c heavy CHAIN, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2014-08-19
Release date:2014-09-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.514 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4N
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CRYSTAL STRUCTURE OF THE ANTI-HIV-1 ANTIBODY 2.2C IN COMPLEX WITH HIV-1 93UG037 GP120
Descriptor:HIV-1 gp120, M48U1 peptide, Antibody 2.2c LIGHT CHAIN, ...
Authors:Acharya, P., Louder, R., Kwong, P.D.
Deposit date:2014-08-19
Release date:2014-11-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.56 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
5U1F
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INITIAL CONTACT OF HIV-1 ENV WITH CD4: CRYO-EM STRUCTURE OF BG505 DS-SOSIP TRIMER IN COMPLEX WITH CD4 AND ANTIBODY PGT145
Descriptor:BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ...
Authors:Acharya, P., Kwong, P.D., Potter, C.S., Carragher, B.
Deposit date:2016-11-28
Release date:2017-02-22
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Nat. Struct. Mol. Biol., 24, 2017
4KA2
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CRYSTAL STRUCTURE OF CD4-MIMETIC MINIPROTEIN M48U12 IN COMPLEX WITH HIV-1 YU2 GP120
Descriptor:HIV-1 YU2 gp120, M48U12, N-ACETYL-D-GLUCOSAMINE
Authors:Acharya, P., Kwong, P.D.
Deposit date:2013-04-21
Release date:2013-06-19
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Interfacial Cavity Filling To Optimize CD4-Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein.
J.Med.Chem., 56, 2013
4H8W
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY N5-I5 IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND SCD4.
Descriptor:HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, FAB LIGHT CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ...
Authors:Tolbert, W.D., Acharya, P., Kwong, P.D., Pazgier, M.
Deposit date:2012-09-24
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4B
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CRYSTAL STRUCTURE OF THE ANTI-HIV-1 ANTIBODY 2.2C
Descriptor:FAB 2.2C LIGHT CHAIN, FAB 2.2C HEAVY CHAIN, SULFATE ION, ...
Authors:McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D.
Deposit date:2014-08-19
Release date:2014-09-10
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4R4H
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING, A32-LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV-1 ENV GP120
Descriptor:HIV-1 Env gp120, T-cell surface glycoprotein CD4, Antibody 2.2c, ...
Authors:Mclellan, J., Acharya, P., Huang, C.-C., Kwong, P.D.
Deposit date:2014-08-19
Release date:2014-09-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (4.28 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4RWY
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 8ANC131 IN COMPLEX WITH HIV-1 CLADE B YU2 GP120
Descriptor:HIV-1 YU2 gp120, Antibody 8ANC131 Heavy chain, Antibody 8ANC131 Light chain, ...
Authors:Acharya, P., Luongo, T.S., Kwong, P.D.
Deposit date:2014-12-08
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.128 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell(Cambridge,Mass.), 161, 2015
4YFL
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CRYSTAL STRUCTURE OF VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY 1B2530 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, 1B2530 heavy chain, 1B2530 Light chain, ...
Authors:Acharya, P., Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2015-02-25
Release date:2015-06-03
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (3.387 Å)
Cite:Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDI
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CRYO-EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:Glycoprotein gp41, Glycoprotein 120, PGT122 Light Chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CUE
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CRYO-EM STRUCTURE AT 4.0 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:Envelope glycoprotein gp120, Envelope glycoprotein gp41, vFP7.04 Heavy chain, ...
Authors:Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-03-26
Release date:2018-07-11
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.
PLoS Pathog., 14, 2018
6CUF
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CRYO-EM STRUCTURE AT 4.2 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP1.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP1.01 heavy chain, vFP1.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.
PLoS Pathog., 14, 2018
6E5P
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BACKBONE MODEL BASED ON CRYO-EM MAP AT 8.5 A OF DOMAIN-SWAPPED, GLYCAN-REACTIVE, NEUTRALIZING ANTIBODY 2G12 BOUND TO HIV-1 ENV BG505 DS-SOSIP, WHICH WAS ALSO BOUND TO CD4-BINDING SITE ANTIBODY VRC03
Descriptor:2G12 Light chain, 2G12 heavy chain, Envelope glycoprotein gp120, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2018-07-21
Release date:2019-02-13
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.
Structure, 27, 2019
6MJZ
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CRYO-EM STRUCTURE OF HUMAN PARAINFLUENZA VIRUS TYPE 3 (HPIV3) IN COMPLEX WITH ANTIBODY PIA174
Descriptor:Fusion glycoprotein F0, PIA174 Fab Heavy chain, PIA174 Fab Light chain
Authors:Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-09-24
Release date:2018-11-14
Last modified:2018-12-12
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MPG
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CRYO-EM STRUCTURE AT 3.2 A RESOLUTION OF HIV-1 FUSION PEPTIDE-DIRECTED ANTIBODY, A12V163-B.01, ELICITED BY VACCINATION OF RHESUS MACAQUES, IN COMPLEX WITH STABILIZED HIV-1 ENV BG505 DS-SOSIP, WHICH WAS ALSO BOUND TO ANTIBODIES VRC03 AND PGT122
Descriptor:A12V163-b.01 Light Chain, Envelope glycoprotein gp41, Envelope glycoprotein gp120, ...
Authors:Acharya, P., Kwong, P.D.
Deposit date:2018-10-06
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Vaccine-Induced Developmental Pathways in Rhesus Macaques for Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide
To Be Published
6MPH
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF HIV-1 FUSION PEPTIDE-DIRECTED ANTIBODY, DF1W-A.01, ELICITED BY VACCINATION OF RHESUS MACAQUES, IN COMPLEX WITH STABILIZED HIV-1 ENV BG505 DS-SOSIP, WHICH WAS ALSO BOUND TO ANTIBODIES VRC03 AND PGT122
Descriptor:DF1W-a.01 heavy chain, DF1W-a.01 Light chain, Envelope glycoprotein gp41, ...
Authors:Acharya, P., Xu, K., Kwong, P.D.
Deposit date:2018-10-06
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Vaccine-Induced Developmental Pathways in Rhesus Macaques for Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide
To Be Published