Author results

1ANR
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CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
Descriptor:RNA REGULATORY ELEMENT TAR
Authors:Aboul-Ela, F., Varani, G., Karn, J.
Deposit date:1996-07-06
Release date:1997-01-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic Acids Res., 24, 1996
1ARJ
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ARG-BOUND TAR RNA, NMR
Descriptor:TAR RNA, ARGININE
Authors:Aboul-Ela, F., Varani, G., Karn, J.
Deposit date:1995-08-30
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.
J.Mol.Biol., 253, 1995
1UUD
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NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT203, BOUND TO HIV-1 TAR RNA
Descriptor:RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE
Authors:Davis, B., Afshar, M., Varani, G., Karn, J., Murchie, A.I.H., Lentzen, G., Drysdale, M.J., Potter, A.J., Bower, J., Aboul-Ela, F.
Deposit date:2003-12-18
Release date:2004-03-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1UUI
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NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT158, BOUND TO HIV-1 TAR RNA
Descriptor:5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3', 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM
Authors:Davis, B., Afshar, M., Varani, G., Karn, J., Murchie, A.I.H., Lentzen, G., Drysdale, M.J., Potter, A.J., Bower, J., Aboul-Ela, F.
Deposit date:2003-12-19
Release date:2004-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1FQZ
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NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE
Descriptor:HEPATITIS C VIRUS IRES DOMAIN IIID
Authors:Klinck, R., Westhof, E., Walker, S., Afshar, M., Collier, A., Aboul-ela, F.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A potential RNA drug target in the hepatitis C virus internal ribosomal entry site.
RNA, 6, 2000
1KP7
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CONSERVED RNA STRUCTURE WITHIN THE HCV IRES EIF3 BINDING SITE
Descriptor:Hepatitis C Virus Internal Ribosome Entry Site Fragment
Authors:Gallego, J., Klinck, R., Collier, A.J., Cole, P.T., Harris, S.J., Harrison, G.P., Aboul-ela, F., Walker, S., Varani, G.
Deposit date:2001-12-29
Release date:2002-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A conserved RNA structure within the HCV IRES eIF3-binding site.
Nat.Struct.Biol., 9, 2002
1OLN
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MODEL FOR THIOSTREPTON ANTIBIOTIC BINDING TO L11 SUBSTRATE FROM 50S RIBOSOMAL RNA
Descriptor:50S RIBOSOMAL PROTEIN L11, THIOSTREPTON, RNA
Authors:Lentzen, G., Klinck, R., Matassova, N., Aboul-Ela, F., Murchie, A.I.H.
Deposit date:2003-08-08
Release date:2003-09-11
Last modified:2017-11-15
Method:SOLUTION NMR, THEORETICAL MODEL
Cite:Structural Basis for Contrasting Activities of Ribosome Binding Thiazole Antibiotics
Chem.Biol., 10, 2003
1UTS
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DESIGNED HIV-1 TAR BINDING LIGAND
Descriptor:RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(3-AMINOPROPOXY)-5-(1H-INDOL-5-YL)BENZYL]-N-(2-PIPERAZIN-1-YLETHYL)AMINE
Authors:Davis, B., Murchie, A.I.H., Aboul-Ela, F., Karn, J.
Deposit date:2003-12-10
Release date:2004-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-Based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 Tar RNA
J.Mol.Biol., 236, 2004
2ESI
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COMPLEX BETWEEN KANAMYCIN A AND THE 16S-RRNA A SITE.
Descriptor:5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', KANAMYCIN A
Authors:Westhof, E.
Deposit date:2005-10-26
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
Nucleic Acids Res., 33, 2005
2ESJ
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COMPLEX BETWEEN LIVIDOMYCIN A AND THE 16S-RRNA A SITE
Descriptor:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,5S,6R)-3-AMINO-5-HYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-4-HYDROXY-2-(HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-4-HYDROXY-TETRAHYDRO-2H-PYRAN-3-YLOXY)-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL
Authors:Westhof, E.
Deposit date:2005-10-26
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
Nucleic Acids Res., 33, 2005
2ET3
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COMPLEX BETWEEN GENTAMICIN C1A AND THE 16S-RRNA A-SITE
Descriptor:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDROXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL
Authors:Westhof, E.
Deposit date:2005-10-27
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res., 33, 2005
2ET4
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COMPLEX BETWEEN NEOMYCIN B AND THE 16S-RRNA A-SITE
Descriptor:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', NEOMYCIN
Authors:Westhof, E.
Deposit date:2005-10-27
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res., 33, 2005
2ET5
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COMPLEX BETWEEN RIBOSTAMYCIN AND THE 16S-RRNA A-SITE
Descriptor:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', RIBOSTAMYCIN, SULFATE ION
Authors:Westhof, E.
Deposit date:2005-10-27
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res., 33, 2005
2ET8
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COMPLEX BETWEEN NEAMINE AND THE 16S-RRNA A-SITE
Descriptor:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL
Authors:Westhof, E.
Deposit date:2005-10-27
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res., 33, 2005
1AJU
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HIV-2 TAR-ARGININAMIDE COMPLEX, NMR, 20 STRUCTURES
Descriptor:TAR RNA, ARGININE
Authors:Brodsky, A.S., Williamson, J.R.
Deposit date:1997-05-10
Release date:1997-12-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the HIV-2 TAR-argininamide complex.
J.Mol.Biol., 267, 1997
1AKX
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HIV-2 TRANS ACTIVATING REGION RNA COMPLEX WITH ARGININAMIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:TAR RNA, ARGININE
Authors:Brodsky, A.S., Williamson, J.R.
Deposit date:1997-05-27
Release date:1997-11-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the HIV-2 TAR-argininamide complex.
J.Mol.Biol., 267, 1997