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4X3K
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BU of 4x3k by Molmil
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27me3 peptide
Descriptor: Chromobox protein homolog 7, H3K27me3 peptide, NICKEL (II) ION, ...
Authors:Ren, C, Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
4X3U
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BU of 4x3u by Molmil
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin
Descriptor: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Chromobox protein homolog 7
Authors:Ren, C, Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
6DNE
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BU of 6dne by Molmil
Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660
Descriptor: Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide}
Authors:Ren, C, Zhou, M.M.
Deposit date:2018-06-06
Release date:2018-07-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.958 Å)
Cite:Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DJC
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BU of 6djc by Molmil
Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide}
Authors:Ren, C, Zhou, M.M.
Deposit date:2018-05-25
Release date:2018-07-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2D82
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BU of 2d82 by Molmil
Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association
Descriptor: 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein
Authors:Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M.
Deposit date:2005-12-01
Release date:2006-04-04
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
Chem.Biol., 13, 2006
1SZV
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BU of 1szv by Molmil
Structure of the Adaptor Protein p14 reveals a Profilin-like Fold with Novel Function
Descriptor: Late endosomal/lysosomal Mp1 interacting protein
Authors:Qian, C, Zhang, Q, Wang, X, Zeng, L, Farooq, A, Zhou, M.M.
Deposit date:2004-04-06
Release date:2005-03-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of the Adaptor Protein p14 Reveals a Profilin-like Fold with Distinct Function
J.Mol.Biol., 347, 2005
1WUG
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BU of 1wug by Molmil
complex structure of PCAF bromodomain with small chemical ligand NP1
Descriptor: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
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BU of 1wum by Molmil
Complex structure of PCAF bromodomain with small chemical ligand NP2
Descriptor: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
6DUV
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BU of 6duv by Molmil
Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
Authors:Babault, N, Zhou, M.M.
Deposit date:2018-06-22
Release date:2019-06-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains
To be published
4X3S
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BU of 4x3s by Molmil
Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide
Descriptor: CITRIC ACID, Chromobox protein homolog 7, FE (III) ION, ...
Authors:Ren, C, Plotnikov, A.N, Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
4X3T
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BU of 4x3t by Molmil
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452
Descriptor: 1,2-ETHANEDIOL, 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone, Chromobox protein homolog 7, ...
Authors:Ren, C, Jakoncic, J, Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
5EJW
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BU of 5ejw by Molmil
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351
Descriptor: (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol, Chromobox protein homolog 7
Authors:Ren, C, Zhou, M.M.
Deposit date:2015-11-02
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.
Acs Med.Chem.Lett., 7, 2016
2G46
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BU of 2g46 by Molmil
structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH
Descriptor: PBCV-1 histone H3-Lys 27 methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, meK27 H3 Peptide
Authors:Qian, C.M, Zheng, L, Zhou, M.M.
Deposit date:2006-02-21
Release date:2006-12-05
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
J.Mol.Biol., 359, 2006
3KMT
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BU of 3kmt by Molmil
Crystal structure of vSET/SAH/H3 ternary complex
Descriptor: A612L protein, Histone H3, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wei, H, Zhou, M.M.
Deposit date:2009-11-11
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Dimerization of a viral SET protein endows its function.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KMJ
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BU of 3kmj by Molmil
Crystal structure of vSET under condition B
Descriptor: A612L protein, SULFATE ION
Authors:Wei, H, Zhou, M.M.
Deposit date:2009-11-10
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dimerization of a viral SET protein endows its function.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KMA
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BU of 3kma by Molmil
Crystal Structure of vSET under Condition A
Descriptor: A612L protein, CHLORIDE ION, GLYCEROL, ...
Authors:Wei, H, Zhou, M.M.
Deposit date:2009-11-10
Release date:2010-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of a viral SET protein endows its function.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LJW
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BU of 3ljw by Molmil
Crystal Structure of the Second Bromodomain of Human Polybromo
Descriptor: ACETATE ION, Protein polybromo-1, SODIUM ION
Authors:Charlop-Powers, Z, Zhou, M.M, Zeng, L, Zhang, Q.
Deposit date:2010-01-26
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Cell Res., 20, 2010
2RNW
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BU of 2rnw by Molmil
The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP
Descriptor: Histone H3, Histone acetyltransferase PCAF
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNX
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BU of 2rnx by Molmil
The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP
Descriptor: Histone H3, Histone acetyltransferase PCAF
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNY
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BU of 2rny by Molmil
Complex Structures of CBP Bromodomain with H4 ack20 Peptide
Descriptor: CREB-binding protein, Histone H4
Authors:Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
1IRS
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BU of 1irs by Molmil
IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: IL-4 RECEPTOR PHOSPHOPEPTIDE, IRS-1
Authors:Zhou, M.-M, Huang, B, Olejniczak, E.T, Meadows, R.P, Shuker, S.B, Miyazaki, M, Trub, T, Shoelson, S.E, Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1SHC
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BU of 1shc by Molmil
SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M, Ravichandran, K.S, Olejniczak, E.T, Petros, A.M, Meadows, R.P, Sattler, M, Harlan, J.E, Wade, W.S, Burakoff, S.J, Fesik, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1TCE
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BU of 1tce by Molmil
SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Descriptor: PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC
Authors:Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
1BVH
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BU of 1bvh by Molmil
SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Descriptor: ACID PHOSPHATASE
Authors:Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W.
Deposit date:1994-05-03
Release date:1994-07-31
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
Descriptor: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, j, Zhou, M.-M.
Deposit date:2017-01-24
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017

 

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