Author results

3RX2
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC SULFONE
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]ethanoic acid
著者Zheng, X., Chen, J., Luo, H., Hu, X.
登録日2011-05-10
公開日2011-11-30
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase
Febs Lett., 586, 2012
3RX3
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid
著者Zheng, X., Chen, J., Luo, H., Hu, X.
登録日2011-05-10
公開日2011-11-30
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
3RX4
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH SULINDAC SULFIDE
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid
著者Zheng, X., Chen, J., Luo, H., Hu, X.
登録日2011-05-10
公開日2011-11-30
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
3S3G
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH TOLMETIN
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tolmetin
著者Zheng, X., Chen, J., Luo, H., Hu, X.
登録日2011-05-18
公開日2012-04-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
3V35
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ALDOSE REDUCTASE COMPLEXED WITH A NITRO COMPOUND
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate, ...
著者Zheng, X., Zhang, L., Chen, Y., Luo, H., Hu, X.
登録日2011-12-13
公開日2012-08-29
最終更新日2014-07-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
3V36
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ALDOSE REDUCTASE COMPLEXED WITH GLCERALDEHYDE
分子名称:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCERALDEHYDE, ...
著者Zheng, X., Zhang, L., Chen, Y., Luo, H., Hu, X.
登録日2011-12-13
公開日2012-08-29
最終更新日2014-07-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
2Z2D
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SOLUTION STRUCTURE OF HUMAN MACROPHAGE ELASTASE (MMP-12) CATALYTIC DOMAIN COMPLEXED WITH A GAMMA-KETO BUTANOIC ACID INHIBITOR
分子名称:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
著者Zheng, X., Ou, L.
登録日2007-05-18
公開日2007-11-20
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor
To be published
3R3I
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CRYSTAL STRUCTURE OF C-TERMINAL TRUNCATION OF UDP-GLUCOSE PYROPHOSPHORYLASE OF HOMO SAPIENS
分子名称:UTP--glucose-1-phosphate uridylyltransferase
著者Zheng, X., Yu, Q.
登録日2011-03-15
公開日2012-03-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.57 Å)
主引用文献Crystal Structure of UDP-glucose Pyrophosphorylase of Homo sapiens
To be Published
4JR5
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STRUCTURE-BASED IDENTIFICATION OF UREAS AS NOVEL NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Gunzner-Toste, J., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-03-21
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.906 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4KFN
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STRUCTURE-BASED DISCOVERY OF NOVEL AMIDE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Gunzner-Toste, J., Liederer, B.M., Ly, J., O'Brien, T., Oh, A., Wang, L., Wang, W., Xiao, Y., Zak, M., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-04-27
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4KFO
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STRUCTURE-BASED DISCOVERY OF NOVEL AMIDE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Gunzner-Tosteb, J., Liederer, B.M., Ly, J., O'Brien, T., Oh, A., Wang, L., Wang, W., Xiao, Y., Zak, M., Zhao, G., Yuen, P., Bair, K.W.
登録日2013-04-27
公開日2013-05-08
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J.Med.Chem., 56, 2013
4KSE
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CRYSTAL STRUCTURE OF A HIV P51 (219-230) DELETION MUTANT
分子名称:HIV p51 subunit, 1,2-ETHANEDIOL
著者Zheng, X., Mueller, G.A., Derose, E.F., Pedersen, L.C., Gabel, S.A., Cuneo, M.J., Krahn, J.M., London, R.E.
登録日2013-05-17
公開日2014-08-13
実験手法X-RAY DIFFRACTION (2.677 Å)
主引用文献Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation.
Nucleic Acids Res., 42, 2014
4LTS
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DISCOVERY OF POTENT AND EFFICACIOUS CYANOGUANIDINE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, PHOSPHATE ION, ...
著者Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, L., Yuen, P., Bair, K.W.
登録日2013-07-23
公開日2013-12-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.692 Å)
主引用文献Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4LWW
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DISCOVERY OF POTENT AND EFFICACIOUS CYANOGUANIDINE-CONTAINING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITORS
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
著者Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, L., Yuen, P., Bair, K.W.
登録日2013-07-28
公開日2013-12-25
最終更新日2014-01-15
実験手法X-RAY DIFFRACTION (1.641 Å)
主引用文献Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
2EXX
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CRYSTAL STRUCTURE OF HSCARG FROM HOMO SAPIENS IN COMPLEX WITH NADP
分子名称:HSCARG protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
著者Dai, X., Chen, Q., Yao, D., Liang, Y., Dong, Y., Gu, X., Zheng, X., Luo, M.
登録日2005-11-09
公開日2006-11-21
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.
Proc.Natl.Acad.Sci.USA, 104, 2007
5EIB
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CRYSTAL STRUCTURE OF CPAP PN2-3 C-TERMINAL LOOP-HELIX IN COMPLEX WITH DARPIN-TUBULIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed ankyrin repeat protein, ...
著者Li, H., Zheng, X.
登録日2015-10-29
公開日2016-10-26
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
Nat Commun, 7, 2016
4LV9
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.807 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVA
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVB
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(acetylamino)phenyl]cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.836 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVD
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, N-(4-nitrophenyl)cyclopropanecarboxamide, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVF
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-2-phenyl-N-(pyridin-4-yl)cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4LVG
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FRAGMENT-BASED IDENTIFICATION OF AMIDES DERIVED FROM TRANS-2-(PYRIDIN-3-YL)CYCLOPROPANECARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-N-[4-(phenylsulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropanecarboxamide, PHOSPHATE ION, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-07-26
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4M6P
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IDENTIFICATION OF AMIDES DERIVED FROM 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-(phenylsulfonyl)benzyl]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, PHOSPHATE ION
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-08-10
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4M6Q
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IDENTIFICATION OF AMIDES DERIVED FROM 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
分子名称:Nicotinamide phosphoribosyltransferase, 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, PYROPHOSPHATE 2-, ...
著者Giannetti, A.M., Zheng, X., Skelton, N., Wang, W., Bravo, B., Feng, Y., Gunzner-Toste, J., Ho, Y., Hua, R., Wang, C., Zhao, Q., Liederer, B.M., Liu, Y., O'Brien, T., Oeh, J., Sampath, D., Shen, Y., Wang, L., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhao, G., Dragovich, P.S.
登録日2013-08-10
公開日2013-09-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
4MPZ
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CRYSTAL STRUCTURE OF TCP10C DOMAIN OF DROSOPHILA MELANOGASTER SAS-4
分子名称:Sas-4, IMIDAZOLE
著者Li, H., Zheng, X.
登録日2013-09-14
公開日2014-01-01
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献The conserved TCP domain of Sas-4/CPAP is essential for Peri-centriolar material tethering during centrosome biogenesis
Proc.Natl.Acad.Sci.USA, 2014