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1MSW
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STRUCTURAL BASIS FOR THE TRANSITION FROM INITIATION TO ELONGATION TRANSCRIPTION IN T7 RNA POLYMERASE
Descriptor:Template DNA, Non-Template DNA, RNA message, ...
Authors:Yin, Y.W., Steitz, T.A.
Deposit date:2002-09-19
Release date:2002-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Science, 298, 2002
1S76
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T7 RNA POLYMERASE ALPHA BETA METHYLENE ATP ELONGATION COMPLEX
Descriptor:DNA (5'-D(P*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), RNA (5'-R(P*AP*CP*AP*CP*GP*GP*CP*GP*A)-3'), ...
Authors:Yin, Y.W., Steitz, T.A.
Deposit date:2004-01-29
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1S77
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T7 RNAP PRODUCT PYROPHOSPHATE ELONGATION COMPLEX
Descriptor:DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), RNA (5'-R(*AP*CP*AP*CP*GP*GP*CP*GP*AP*(3DA))-3'), ...
Authors:Yin, Y.W., Steitz, T.A.
Deposit date:2004-01-29
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
2PI4
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T7RNAP COMPLEXED WITH A PHI10 PROTEIN AND INITIATING GTPS.
Descriptor:5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', DNA-directed RNA polymerase, ...
Authors:Kennedy, W.P., Momand, J.R., Yin, Y.W.
Deposit date:2007-04-12
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
2PI5
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T7 RNA POLYMERASE COMPLEXED WITH A PHI10 PROMOTER
Descriptor:5'-D(*CP*TP*TP*C*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', DNA-directed RNA polymerase
Authors:Kennedy, W.P., Momand, J.R., Yin, Y.W.
Deposit date:2007-04-12
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
3IKL
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CRYSTAL STRUCTURE OF POL GB DELTA-I4.
Descriptor:DNA polymerase subunit gamma-2, mitochondrial
Authors:Lee, Y.S., Kennedy, W.D., Yin, Y.W.
Deposit date:2009-08-06
Release date:2010-08-25
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
3IKM
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL DNA POLYMERASE HOLOENZYME
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2
Authors:Lee, Y.-S., Kennedy, W.D., Yin, Y.W.
Deposit date:2009-08-06
Release date:2009-11-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
4MGW
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COMPARISON OF THE STRUCTURAL AND DYNAMIC EFFECTS OF 5-METHYLCYTOSINE AND 5-CHLOROCYTOSINE IN A CPG DINUCLEOTIDE SEQUENCE
Descriptor:ClC containing Dickerson-Drew dodecamer, MAGNESIUM ION
Authors:Theruvathu, J.A., Whitney, Y., Montgomery Pettitt, B., Sowers, L.C.
Deposit date:2013-08-29
Release date:2013-11-06
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence.
Biochemistry, 52, 2013
4MKW
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COMPARISON OF THE STRUCTURAL AND DYNAMIC EFFECTS OF 5-METHYLCYTOSINE AND 5-CHLOROCYTOSINE IN A CPG DINUCLEOTIDE SEQUENCE
Descriptor:5methylC DNA dodecamer, MAGNESIUM ION
Authors:Yin, Y.W.
Deposit date:2013-09-05
Release date:2013-11-06
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence.
Biochemistry, 52, 2013
4ZTU
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STRUCTURAL BASIS FOR PROCESSIVITY AND ANTIVIRAL DRUG TOXICITY IN HUMAN MITOCHONDRIAL DNA REPLICASE
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Szymanski, M.R., Kuznestov, V.B., Shumate, C.K., Meng, Q., Lee, Y.-S., Patel, G., Patel, S.S., Yin, Y.W.
Deposit date:2015-05-15
Release date:2015-09-23
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
EMBO J., 34, 2015
4ZTZ
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STRUCTURAL BASIS FOR PROCESSIVITY AND ANTIVIRAL DRUG TOXICITY IN HUMAN MITOCHONDRIAL DNA REPLICASE
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Szymanski, M.R., Yin, Y.W.
Deposit date:2015-05-15
Release date:2015-09-23
Method:X-RAY DIFFRACTION (3.442 Å)
Cite:Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
EMBO J., 34, 2015
5C51
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PROBING THE STRUCTURAL AND MOLECULAR BASIS OF NUCLEOTIDE SELECTIVITY BY HUMAN MITOCHONDRIAL DNA POLYMERASE GAMMA
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Sohl, C.D., Szymanski, M.R., Mislak, A.C., Shumate, C.K., Amiralaei, S., Schinazi, R.F., Anderson, K.S., Whitney, Y.Y.
Deposit date:2015-06-19
Release date:2016-05-11
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (3.426 Å)
Cite:Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Proc.Natl.Acad.Sci.USA, 112, 2015
5C52
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PROBING THE STRUCTURAL AND MOLECULAR BASIS OF NUCLEOTIDE SELECTIVITY BY HUMAN MITOCHONDRIAL DNA POLYMERASE GAMMA
Descriptor:DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Sohl, C.D., Szymanski, M.R., Mislak, A.C., Shumate, C.K., Amiralaei, S., Schinazi, R.F., Anderson, K.S., Yin, Y.W.
Deposit date:2015-06-19
Release date:2016-05-11
Method:X-RAY DIFFRACTION (3.637 Å)
Cite:Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Proc.Natl.Acad.Sci.USA, 112, 2015
5C53
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PROBING THE STRUCTURAL AND MOLECULAR BASIS OF NUCLEOTIDE SELECTIVITY BY HUMAN MITOCHONDRIAL DNA POLYMERASE GAMMA
Descriptor:DNA polymerase subunit gamma-1, Pol gamma B, DNA (26-MER), ...
Authors:Sohl, C.D., Szymanski, M.R., Mislak, A.C., Shumate, C.K., Amiralaei, S., Schinazi, R.F., Anderson, K.S., Yin, Y.W.
Deposit date:2015-06-19
Release date:2016-01-27
Method:X-RAY DIFFRACTION (3.567 Å)
Cite:Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DK4
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CRYSTAL STRUCTURE ANALYSIS OF TRYPTOPHANYL-TRNA SYNTHETASE FROM BACILLUS STEAROTHERMOPHILUS IN COMPLEX WITH INDOLMYCIN AND MG*ATP
Descriptor:Tryptophan--tRNA ligase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Williams, T., Yin, W.Y., Carter Jr., C.W.
Deposit date:2015-09-02
Release date:2015-11-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based.
J.Biol.Chem., 291, 2016
5T3V
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A NOVEL DOMAIN IN HUMAN EXOG CONVERTS APOPTOTIC ENDONUCLEASE TO DNA-REPAIR ENZYME
Descriptor:Nuclease EXOG, mitochondrial, MANGANESE (II) ION, ...
Authors:Szymanski, M.R., Yin, W.Y.
Deposit date:2016-08-26
Release date:2017-05-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Nat Commun, 8, 2017
5T40
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A NOVEL DOMAIN IN HUMAN EXOG CONVERTS APOPTOTIC ENDONUCLEASE TO DNA-REPAIR ENZYME
Descriptor:Nuclease EXOG, mitochondrial, SULFATE ION, ...
Authors:Szymanski, M.R., Yin, W.Y.
Deposit date:2016-08-27
Release date:2017-05-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Nat Commun, 8, 2017
5T4I
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A NOVEL DOMAIN IN HUMAN EXOG CONVERTS APOPTOTIC ENDONUCLEASE TO DNA-REPAIR ENZYME
Descriptor:Nuclease EXOG, mitochondrial, DNA (5'-D(P*CP*TP*GP*AP*CP*GP*TP*GP*C)-3'), ...
Authors:Szymanski, M.R., Yin, W.Y.
Deposit date:2016-08-29
Release date:2017-05-17
Method:X-RAY DIFFRACTION (2.389 Å)
Cite:A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Nat Commun, 8, 2017
5T5C
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A NOVEL DOMAIN IN HUMAN EXOG CONVERTS APOPTOTIC ENDONUCLEASE TO DNA-REPAIR ENZYME
Descriptor:Nuclease EXOG, mitochondrial, DNA (5'-D(P*CP*TP*GP*AP*CP*GP*TP*GP*C)-3'), ...
Authors:Szymanski, M.R., Yin, W.Y.
Deposit date:2016-08-30
Release date:2017-05-17
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Nat Commun, 8, 2017