Author results

2GTD
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CRYSTAL STRUCTURE OF A TYPE III PANTOTHENATE KINASE: INSIGHT INTO THE CATALYSIS OF AN ESSENTIAL COENZYME A BIOSYNTHETIC ENZYME UNIVERSALLY DISTRIBUTED IN BACTERIA
Descriptor:Type III Pantothenate Kinase
Authors:Yang, K., Eyobo, Y., Brand, A.L., Martynowski, D., Tomchick, D.
Deposit date:2006-04-27
Release date:2006-08-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria.
J.Bacteriol., 188, 2006
3BEX
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TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PANTOTHENATE
Descriptor:Type III pantothenate kinase, PHOSPHATE ION, PANTOTHENOIC ACID
Authors:Yang, K., Huerta, C., Strauss, E., Zhang, H.
Deposit date:2007-11-20
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
3BF1
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TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PANTOTHENATE AND ADP
Descriptor:Type III pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, PANTOTHENOIC ACID
Authors:Yang, K., Huerta, C., Strauss, E., Zhang, H.
Deposit date:2007-11-20
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
3BF3
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TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PRODUCT PHOSPHOPANTOTHENATE
Descriptor:Type III pantothenate kinase, MAGNESIUM ION, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine
Authors:Yang, K., Huerta, C., Strauss, E., Zhang, H.
Deposit date:2007-11-20
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
3E66
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CRYSTAL STRUCTURE OF THE BETA-FINGER DOMAIN OF YEAST PRP8
Descriptor:PRP8
Authors:Yang, K., Zhang, L., Xu, T., Heroux, A., Zhao, R.
Deposit date:2008-08-14
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5HQP
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CRYSTAL STRUCTURE OF THE ERP44-PEROXIREDOXIN 4 COMPLEX
Descriptor:Peroxiredoxin-4, Endoplasmic reticulum resident protein 44
Authors:Yang, K., Li, D.F., Wang, X., Wang, C.C.
Deposit date:2016-01-22
Release date:2016-10-12
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.
Structure, 24, 2016
5V7Q
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CRYO-EM STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH A POTENT LINEZOLID ANALOG
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ...
Authors:Yang, K., Chang, J.-Y., Cui, Z., Zhang, J.
Deposit date:2017-03-20
Release date:2017-09-20
Last modified:2017-11-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
Nucleic Acids Res., 45, 2017
5V93
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CRYO-EM STRUCTURE OF THE 70S RIBOSOME FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH CAPREOMYCIN
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ...
Authors:Yang, K., Chang, J.-Y., Cui, Z., Li, X., Meng, R., Duan, L., Thongchol, J., Jakana, J., Huwe, C., Sacchettini, J., Zhang, J.
Deposit date:2017-03-22
Release date:2017-09-20
Last modified:2017-11-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
Nucleic Acids Res., 45, 2017
6DMX
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HBZ56 IN COMPLEX WITH KIX AND C-MYB
Descriptor:BZIP factor, Transcriptional activator Myb, CREB-binding protein
Authors:Yang, K., Wright, P.E., Stanfield, R.L.
Deposit date:2018-06-05
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DNQ
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HBZ77 IN COMPLEX WITH KIX AND C-MYB
Descriptor:BZIP factor, Transcriptional activator Myb, CREB-binding protein, ...
Authors:Yang, K., Wright, P.E., Stanfield, R.L.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5Z0R
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STRUCTURAL INSIGHT INTO THE ZIKA VIRUS CAPSID ENCAPSULATING THE VIRAL GENOME
Descriptor:Extracellular solute-binding protein family 1,viral genome protein, MALTOSE
Authors:Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., Zhang, T., Duan, Y., Xue, X., Mi, K., Ji, X., Wang, Z., Yang, H.
Deposit date:2017-12-20
Release date:2018-04-11
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insight into the Zika virus capsid encapsulating the viral genome.
Cell Res., 28, 2018
5Z0V
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STRUCTURAL INSIGHT INTO THE ZIKA VIRUS CAPSID ENCAPSULATING THE VIRAL GENOME
Descriptor:Extracellular solute-binding protein family 1,viral genome protein, MALTOSE
Authors:Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., Zhang, T., Duan, Y., Xue, X., Mi, K., Ji, X., Wang, Z., Yang, H.
Deposit date:2017-12-21
Release date:2018-04-11
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.913 Å)
Cite:Structural insight into the Zika virus capsid encapsulating the viral genome.
Cell Res., 28, 2018
1WNO
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CRYSTAL STRUCTURE OF A NATIVE CHITINASE FROM ASPERGILLUS FUMIGATUS YJ-407
Descriptor:Chitinase, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, SULFATE ION, ...
Authors:Hu, H., Wang, G., Yang, H., Zhou, J., Mo, L., Yang, K., Jin, C., Jin, C., Rao, Z.
Deposit date:2004-08-07
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a native chitinase from Aspergillus fumigatus YJ-407
To be Published
5JMT
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS3 HELICASE
Descriptor:NS3 helicase
Authors:Tian, H., Ji, X., Yang, X., Xie, W., Yang, K., Chen, C., Wu, C., Chi, H., Mu, Z., Wang, Z., Yang, H.
Deposit date:2016-04-29
Release date:2016-05-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:The crystal structure of Zika virus helicase: basis for antiviral drug design
Protein Cell, 7, 2016
1WOF
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Rao, Z.
Deposit date:2004-08-18
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMD
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9
Descriptor:3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-09
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMP
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CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMQ
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2D2D
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2
Descriptor:3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z.
Deposit date:2005-09-08
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
5EU8
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STRUCTURE OF FIPV MAIN PROTEASE IN COMPLEX WITH DUAL INHIBITORS
Descriptor:main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, ZINC ION, ...
Authors:Wang, F., Chen, C., Liu, X., Yang, K., Xu, X., Yang, H.
Deposit date:2015-11-18
Release date:2015-12-30
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
J.Virol., 90, 2015
5GWY
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STRUCTURE OF MAIN PROTEASE FROM HUMAN CORONAVIRUS NL63: INSIGHTS FOR WIDE SPECTRUM ANTI-CORONAVIRUS DRUG DESIGN
Descriptor:main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Wang, F., Chen, C., Tan, W., Yang, K., Yang, H.
Deposit date:2016-09-14
Release date:2017-09-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
Sci Rep, 6, 2016
5GWZ
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THE STRUCTURE OF PORCINE EPIDEMIC DIARRHEA VIRUS MAIN PROTEASE IN COMPLEX WITH AN INHIBITOR
Descriptor:PEDV main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Wang, F., Chen, C., Yang, K., Liu, X., Liu, H., Xu, Y., Chen, X., Liu, X., Cai, Y., Yang, H.
Deposit date:2016-09-14
Release date:2017-03-29
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60, 2017
5GXJ
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ZIKA VIRUS NS2B-NS3 PROTEASE
Descriptor:FLAVIVIRUS_NS2B,LINKER,Peptidase S7
Authors:Yang, H., Chen, X., Ji, X., Xiong, Y., Yang, K.
Deposit date:2016-09-18
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Viral protease activation mechanism
To Be Published
5X8Y
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A MUTATION IDENTIFIED IN NEONATAL MICROCEPHALY DESTABILIZES ZIKA VIRUS NS1 ASSEMBLY IN VITRO
Descriptor:ZIKV NS1
Authors:Wang, D., Chen, C., Liu, S., Zhou, H., Yang, K., Zhao, Q., Ji, X., Chen, C., Xie, W., Wang, Z., Mi, L.Z., Yang, H.
Deposit date:2017-03-03
Release date:2017-05-17
Method:X-RAY DIFFRACTION (2.817 Å)
Cite:A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro
Sci Rep, 7, 2017
3V3E
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CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-13
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
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