Author results

1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor:SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1GXC
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FHA DOMAIN FROM HUMAN CHK2 KINASE IN COMPLEX WITH A SYNTHETIC PHOSPHOPEPTIDE
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE
Authors:Li, J., Williams, B.L., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
Deposit date:2002-04-02
Release date:2002-06-13
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
Mol.Cell, 9, 2002
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
Descriptor:14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJB
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Descriptor:14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1T15
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CRYSTAL STRUCTURE OF THE BRCA1 BRCT DOMAINS IN COMPLEX WITH THE PHOSPHORYLATED INTERACTING REGION FROM BACH1 HELICASE
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1
Authors:Clapperton, J.A., Manke, I.A., Lowery, D.M., Ho, T., Haire, L.F., Yaffe, M.B., Smerdon, S.J.
Deposit date:2004-04-15
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
1UMW
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STRUCTURE OF A HUMAN PLK1 POLO-BOX DOMAIN/PHOSPHOPEPTIDE COMPLEX
Descriptor:SERINE/THREONINE-PROTEIN KINASE PLK, PEPTIDE
Authors:Rellos, P., Elia, A., Yaffe, M.B., Smerdon, S.J.
Deposit date:2003-08-29
Release date:2003-10-16
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
Cell(Cambridge,Mass.), 115, 2003
1YWT
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CRYSTAL STRUCTURE OF THE HUMAN SIGMA ISOFORM OF 14-3-3 IN COMPLEX WITH A MODE-1 PHOSPHOPEPTIDE
Descriptor:14-3-3 protein sigma, synthetic optimal phosphopeptide (mode-1), CALCIUM ION
Authors:Wilker, E.W., Grant, R.A., Artim, S.C., Yaffe, M.B.
Deposit date:2005-02-18
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
2AZM
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CRYSTAL STRUCTURE OF THE MDC1 BRCT REPEAT IN COMPLEX WITH THE HISTONE TAIL OF GAMMA-H2AX
Descriptor:Mediator of DNA damage checkpoint protein 1, GAMMA-H2AX HISTONE
Authors:Clapperton, J.A., Stucki, M., Mohammad, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
Deposit date:2005-09-12
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
2C1J
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MOLECULAR BASIS FOR THE RECOGNITION OF PHOSPHORYLATED AND PHOSPHOACETYLATED HISTONE H3 BY 14-3-3
Descriptor:14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I., Macdonald, N., Noble, M.E.M., Nguyen, A., Yaffe, M.B., Clynes, D., Moggs, J.G., Orphanides, G., Thomson, S., Edmunds, J.W., Clayton, A.L., Endicott, J.A., Mahadevan, L.C.
Deposit date:2005-09-15
Release date:2005-11-02
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2C1N
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MOLECULAR BASIS FOR THE RECOGNITION OF PHOSPHORYLATED AND PHOSPHOACETYLATED HISTONE H3 BY 14-3-3
Descriptor:14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I., Macdonald, N., Noble, M.E.M., Nguyen, A., Yaffe, M.B., Clynes, D., Moggs, J.G., Orphanides, G., Thomson, S., Edmunds, J.W., Clayton, A.L., Endicott, J.A., Mahadevan, L.C.
Deposit date:2005-09-16
Release date:2005-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2PIE
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CRYSTAL STRUCTURE OF THE FHA DOMAIN OF RNF8 IN COMPLEX WITH ITS OPTIMAL PHOSPHOPEPTIDE
Descriptor:E3 ubiquitin-protein ligase RNF8, phosphopeptide
Authors:Grant, R.A., Yaffe, M.B.
Deposit date:2007-04-13
Release date:2007-12-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.
Cell(Cambridge,Mass.), 131, 2007
3C5L
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH PPHSPT PEPTIDE
Descriptor:Serine/threonine-protein kinase PLK1, Peptide
Authors:Lim, D.C., Yaffe, M.B.
Deposit date:2008-01-31
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
3FVH
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH AC-LHSPTA-NH2 PEPTIDE
Descriptor:Serine/threonine-protein kinase PLK1, Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide
Authors:Lim, D.C., Yaffe, M.B.
Deposit date:2009-01-15
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Nat.Struct.Mol.Biol., 16, 2009
3RQ7
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH A C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR
Descriptor:Serine/threonine-protein kinase PLK1, C6H5(CH2)8-derivatized peptide inhibitor
Authors:Liu, F., Park, J.-E., Qian, W.-J., Lim, D.C., Graber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
Deposit date:2011-04-27
Release date:2011-07-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
4DFW
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OXIME-BASED POST SOLID-PHASE PEPTIDE DIVERSIFICATION: IDENTIFICATION OF HIGH AFFINITY POLO-LIKE KINASE 1 (PLK1) POLO-BOX DOMAIN BINDING PEPTIDES
Descriptor:Serine/threonine-protein kinase PLK1, Peptide, CHLORIDE ION
Authors:Liu, F., Park, J.-E., Qian, W.-J., Lim, D., Gr ber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
Deposit date:2012-01-24
Release date:2012-03-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
4JIZ
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HUMAN MOB1-PHOSPHOPEPTIDE COMPLEX
Descriptor:MOB kinase activator 1A, phosphopeptide, ZINC ION
Authors:Stach, L., Ogrodowicz, R.W., Rock, J.M., Lim, D., Yaffe, M.B., Amon, A., Smerdon, S.J.
Deposit date:2013-03-07
Release date:2013-04-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Science, 340, 2013
4JRN
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ROP18 KINASE DOMAIN IN COMPLEX WITH AMP-PNP AND SUCROSE
Descriptor:Rhoptry kinase family protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Lim, D., Gold, D.A., Lindsay, J., Rosowski, E.E., Niedelman, W., Yaffe, M.B., Saeij, J.P.J.
Deposit date:2013-03-21
Release date:2013-10-23
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.
J.Biol.Chem., 288, 2013
4O6W
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PEPTIDE-BASED INHIBITORS OF PLK1 POLO-BOX DOMAIN
Descriptor:Serine/threonine-protein kinase PLK1, Peptide-Based inhibitor
Authors:Qian, W.-J., Park, J.-E., Lim, D.C., Park, S.-Y., Lee, K.-W., Yaffe, M.B., Lee, K.S., Burke, T.R.
Deposit date:2013-12-23
Release date:2014-12-03
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014
4X9R
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 3B
Descriptor:Serine/threonine-protein kinase PLK1, Phosphopeptide macrocycle 3B
Authors:Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
Deposit date:2014-12-11
Release date:2015-07-29
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
4X9V
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 3C
Descriptor:Serine/threonine-protein kinase PLK1, Phosphopeptide macrocycle 3C
Authors:Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
Deposit date:2014-12-11
Release date:2015-07-29
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.429 Å)
Cite:Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
4X9W
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 4C
Descriptor:Serine/threonine-protein kinase PLK1, Macrocyclic phosphopeptide 4C
Authors:Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
Deposit date:2014-12-11
Release date:2015-07-29
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
6AX4
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH HISTIDINE N(TAU)-CYCLIZED MACROCYCLE 5B.
Descriptor:Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE
Authors:Grant, R.A., Hymel, D., Yaffe, M.B., Burke, T.R.
Deposit date:2017-09-06
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
1I3Z
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MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Lu, J., Poy, F., Morra, M., Terhorst, C., Eck, M.J.
Deposit date:2001-02-19
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Eur.J.Biochem., 20, 2001
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