Author results

6UH3
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CRYSTAL STRUCTURE OF BACTERIAL HELIORHODOPSIN 48C12
Descriptor:Heliorhodopsin, RETINAL, TRIETHYLENE GLYCOL, ...
Authors:Lu, Y., Zhou, X.E., Gao, X., Xia, R., Xu, Z., Wang, N., Leng, Y., Melcher, K., Xu, H.E., He, Y.
Deposit date:2019-09-26
Release date:2019-12-04
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of bacterial heliorhodopsin 48C12
To Be Published
6PWC
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A COMPLEX STRUCTURE OF ARRESTIN-2 BOUND TO NEUROTENSIN RECEPTOR 1
Descriptor:Neurotensin receptor type 1, Neurotensin peptide, Beta-arrestin-1, ...
Authors:Yin, W., Li, Z., Jin, M., Yin, Y.-L., de Waal, P.W., Pal, K., Gao, X., He, Y., Gao, J., Wang, X., Zhang, Y., Zhou, H., Melcher, K., Jiang, Y., Cong, Y., Zhou, X.E., Yu, X., Xu, H.E.
Deposit date:2019-07-22
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:A complex structure of arrestin-2 bound to a G protein-coupled receptor
To Be Published
6PAX
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CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS
Descriptor:26 NUCLEOTIDE DNA, HOMEOBOX PROTEIN PAX-6
Authors:Xu, H.E., Rould, M.A., Xu, W., Epstein, J.A., Maas, R.L., Pabo, C.O.
Deposit date:1999-04-22
Release date:1999-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.
Genes Dev., 13, 1999
6OE8
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THE CRYSTAL STRUCTURE OF HYPER-THERMOSTABLE AGURICASE MUTANT K12C/E286C
Descriptor:Uricase, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ...
Authors:Shi, Y., Wang, T., Zhou, X.E., Liu, Q., Jiang, Y., Xu, H.E.
Deposit date:2019-03-27
Release date:2019-08-21
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy.
Acta Pharmacol.Sin., 40, 2019
6NBI
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBH
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBF
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6MS7
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVE PPAR-GAMMA MODULATOR VSP-77
Descriptor:Peroxisome proliferator-activated receptor gamma, PGC1 LXXLL motif, {[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic acid
Authors:Yi, W., Jiang, H., Zhou, X.E., Shi, J., Zhao, G., Zhang, X., Sun, Y., Suino-Powell, K., Li, J., Li, J., Melcher, K., Xu, H.E.
Deposit date:2018-10-16
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Identification and Structural Insight of a Safe and Effective PPAR-gamma Modulator for Anti-Diabetic Drug Discovery
To Be Published
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
6C9J
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Brunzelle, J.S., Hitoshi, Y., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9H
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NON-PHOSPHORYLATED AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9G
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R739
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9F
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
5VT7
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ABA-MIMICKING LIGAND AMC1BETA IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-L., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.X., Zhu, J.-K.
Deposit date:2017-05-15
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.624 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5VSR
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ABA-MIMICKING LIGAND AMF4 IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-L., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.X., Zhu, J.-K.
Deposit date:2017-05-12
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.618 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5VSQ
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ABA-MIMICKING LIGAND AMF2BETA IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 1-(3,5-difluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-L., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.X., Zhu, J.-K.
Deposit date:2017-05-12
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.618 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5VS5
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ABA-MIMICKING LIGAND AMF2ALPHA IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 1-(2,3-difluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-W., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.E., Zhu, J.-K.
Deposit date:2017-05-11
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5VRO
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ABA-MIMICKING LIGAND AMF1BETA IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 1-(3-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-L., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.X., Zhu, J.-K.
Deposit date:2017-05-11
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.257 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5VR7
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ABA-MIMICKING LIGAND AMF1ALPHA IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 1-(2-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide, ...
Authors:Cao, M.-J., Zhang, Y.-L., Liu, X., Huang, H., Zhou, X.E., Wang, W.-L., Zeng, A., Zhao, C.-Z., Si, T., Du, J.-M., Wu, W.-W., Wang, F.-X., Xu, H.E., Zhu, J.-K.
Deposit date:2017-05-10
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Combining chemical and genetic approaches to increase drought resistance in plants.
Nat Commun, 8, 2017
5V54
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CRYSTAL STRUCTURE OF 5-HT1B RECEPTOR IN COMPLEX WITH METHIOTHEPIN
Descriptor:5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Authors:Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
Deposit date:2017-03-13
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Cell Discov, 2018
5UWG
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THE CRYSTAL STRUCTURE OF FZ4-CRD IN COMPLEX WITH PALMITOLEIC ACID
Descriptor:Frizzled-4, PALMITOLEIC ACID, N-ACETYL-D-GLUCOSAMINE
Authors:Ke, J., DeBruine, Z.J., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2017-02-21
Release date:2017-06-14
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Genes Dev., 31, 2017
5UJV
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CRYSTAL STRUCTURE OF FEPYR1 IN COMPLEX WITH ABSCISIC ACID
Descriptor:PYR1, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid
Authors:Ren, Z., Wang, Z., Zhou, X.E., Hong, Y., Cao, M., Chan, Z., Liu, X., Shi, H., Xu, H.E., Zhu, J.-K.
Deposit date:2017-01-19
Release date:2017-11-08
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1.
Sci Rep, 7, 2017
5TWO
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVELY PPAR GAMMA-MODULATING LIGAND VSP-51
Descriptor:Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide
Authors:Yi, W., Shi, J., Zhao, G., Zhou, X.E., Suino-Powell, K., Melcher, K., Xu, H.E.
Deposit date:2016-11-14
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro.
Sci Rep, 7, 2017