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5KYK
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BU of 5kyk by Molmil
Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Descriptor: 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas
Authors:Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S.
Deposit date:2016-07-21
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
1DQH
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BU of 1dqh by Molmil
CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS
Descriptor: RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3'), RNA (5'-R(*GP*CP*CP*AP*CP*CP*CP*UP*G)-3')
Authors:Xiong, Y, Sundaralingam, M.
Deposit date:2000-01-04
Release date:2000-11-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
RNA, 6, 2000
1DQF
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BU of 1dqf by Molmil
CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS
Descriptor: CALCIUM ION, RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3'), RNA (5'-R(*GP*CP*CP*AP*CP*CP*CP*UP*G)-3')
Authors:Xiong, Y, Sundaralingam, M.
Deposit date:2000-01-04
Release date:2000-11-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
RNA, 6, 2000
2PFF
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BU of 2pff by Molmil
Structural Insights of Yeast Fatty Acid Synthase
Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Tail protein
Authors:Xiong, Y, Lomakin, I.B, Steitz, T.A.
Deposit date:2007-04-04
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural Insights of Yeast Fatty Acid Synthase
Cell(Cambridge,Mass.), 129, 2007
1R89
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BU of 1r89 by Molmil
Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes
Descriptor: CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8C
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BU of 1r8c by Molmil
Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide
Descriptor: MANGANESE (II) ION, SODIUM ION, URIDINE 5'-TRIPHOSPHATE, ...
Authors:Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8A
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BU of 1r8a by Molmil
Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes
Descriptor: MANGANESE (II) ION, SODIUM ION, tRNA nucleotidyltransferase
Authors:Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8B
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BU of 1r8b by Molmil
Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1TFW
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BU of 1tfw by Molmil
How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template
Descriptor: 5'-R(*CP*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3', 5'-R(*GP*CP*GP*GP*AP*CP*CP*CP*GP*CP*AP*C)-3', 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3', ...
Authors:Xiong, Y, Steitz, T.A.
Deposit date:2004-05-27
Release date:2004-08-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
1SZ1
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BU of 1sz1 by Molmil
Mechanism of CCA-adding enzymes specificity revealed by crystal structures of ternary complexes
Descriptor: T-RNA (76-MER), tRNA nucleotidyltransferase
Authors:Xiong, Y, Steitz, T.A.
Deposit date:2004-04-02
Release date:2004-08-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (6.21 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
1TFY
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BU of 1tfy by Molmil
How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template
Descriptor: 5'-R(*CP*GP*CP*GP*GP*AP*UP*C)-3', 5'-R(*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3', 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*AP*C)-3', ...
Authors:Xiong, Y, Steitz, T.A.
Deposit date:2004-05-27
Release date:2004-08-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
1J9H
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BU of 1j9h by Molmil
Crystal Structure of an RNA Duplex with Uridine Bulges
Descriptor: 5'-R(*GP*UP*GP*UP*CP*GP*(CBR)P*AP*C)-3', CALCIUM ION
Authors:Xiong, Y, Deng, J, Sudarsanakumar, C, Sundaralingam, M.
Deposit date:2001-05-25
Release date:2001-10-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of an RNA duplex r(gugucgcac)(2) with uridine bulges.
J.Mol.Biol., 313, 2001
1JZV
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BU of 1jzv by Molmil
Crystal structure of a bulged RNA from the SL2 stem-loop of the HIV-1 psi-RNA
Descriptor: 5'-R(*CP*AP*GP*UP*AP*CP*GP*(5IC)P*C)-3', 5'-R(*GP*GP*CP*GP*AP*CP*(5BU)P*G)-3', MAGNESIUM ION
Authors:Xiong, Y, Sudarsanakumar, C, Deng, J, Pan, B, Sundaralingam, M.
Deposit date:2001-09-17
Release date:2003-11-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of a Bulged RNA from the SL2 Stem-loop of the HIV-1 psi-RNA
To be Published
479D
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BU of 479d by Molmil
CRYSTAL STRUCTURE A DNA:RNA HYBRID DUPLEX, A DYNAMIC MODEL FOR RNASE H RECOGNITION
Descriptor: DNA (5'-D(*CP*TP*CP*TP*TP*CP*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3')
Authors:Xiong, Y, Sundaralingam, M.
Deposit date:1999-07-08
Release date:2000-05-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary polypyrimidine DNA d(CTCTTCTTC).
Nucleic Acids Res., 28, 2000
421D
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BU of 421d by Molmil
5'-D(*TP*TP*CP*TP*TP*(BRO)CP*TP*TP*C)-3', 5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3'
Descriptor: DNA (5'-D(*TP*TP*CP*TP*TP*(CBR)P*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3')
Authors:Xiong, Y, Sundaralingam, M.
Deposit date:1998-08-16
Release date:1999-01-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and conformation of a DNA-RNA hybrid duplex with a polypurine RNA strand: d(TTCTTBr5CTTC)-r(GAAGAAGAA).
Structure, 6, 1998
4WHJ
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BU of 4whj by Molmil
Myxovirus Resistance Protein 2 (MxB)
Descriptor: Interferon-induced GTP-binding protein Mx2
Authors:Xiong, Y, Fribourgh, J.L, Nguyen, H.C.
Deposit date:2014-09-22
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into HIV-1 Restriction by MxB.
Cell Host Microbe, 16, 2014
8WW2
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BU of 8ww2 by Molmil
GPR3/Gs complex
Descriptor: CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:He, Y, Xiong, Y.
Deposit date:2023-10-24
Release date:2024-02-14
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Identification of oleic acid as an endogenous ligand of GPR3.
Cell Res., 34, 2024
6QPL
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BU of 6qpl by Molmil
Crystal structure of Spindlin1 in complex with the inhibitor MS31
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T.
Deposit date:2019-02-14
Release date:2019-07-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
J.Med.Chem., 62, 2019
3G8Q
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BU of 3g8q by Molmil
A cytidine deaminase edits C-to-U in transfer RNAs in archaea
Descriptor: Predicted RNA-binding protein, contains THUMP domain, SODIUM ION, ...
Authors:Xiong, Y, Stanley, B.J.
Deposit date:2009-02-12
Release date:2009-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A cytidine deaminase edits C to U in transfer RNAs in Archaea
Science, 324, 2009
5TTF
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BU of 5ttf by Molmil
Crystal structure of catalytic domain of G9a with MS012
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EHMT2, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ...
Authors:DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TUY
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BU of 5tuy by Molmil
Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124
Descriptor: 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ...
Authors:Babault, N, Xiong, Y, Liu, J, Jin, J.
Deposit date:2016-11-07
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TUZ
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BU of 5tuz by Molmil
Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124
Descriptor: 1,2-ETHANEDIOL, 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT1, ...
Authors:Babault, N, Xiong, Y, Liu, J, Jin, J.
Deposit date:2016-11-07
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TTG
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BU of 5ttg by Molmil
Crystal structure of catalytic domain of GLP with MS012
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5VSC
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BU of 5vsc by Molmil
Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13
Descriptor: 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ...
Authors:Babault, N, Xiong, Y, Liu, J, Jin, J.
Deposit date:2017-05-11
Release date:2017-07-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
Bioorg. Med. Chem., 25, 2017
5VSF
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BU of 5vsf by Molmil
Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 17
Descriptor: 1,4-DIETHYLENE DIOXIDE, GLYCEROL, Histone-lysine N-methyltransferase EHMT1, ...
Authors:Babault, N, Xiong, Y, Liu, J, Jin, J.
Deposit date:2017-05-11
Release date:2017-07-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
Bioorg. Med. Chem., 25, 2017

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