Author results

5Z8G
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BRD4 BROMODOMAIN 1 WITH AN INHIBITOR
Descriptor:Bromodomain-containing protein 4, 1-ethyl-6-[(3R)-3-oxidanylpiperidin-1-yl]sulfonyl-benzo[cd]indol-2-one, DIMETHYL SULFOXIDE
Authors:Xiao, S., Chen, S., Chen, H.
Deposit date:2018-01-31
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:BRD4 Bromodomain 1 with an inhibitor
To Be Published
5Z8R
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BRD4 BROMODOMAIN 1 WITH AN INHIBITOR
Descriptor:Bromodomain-containing protein 4, 1-ethyl-6-[(3S)-3-oxidanylpiperidin-1-yl]sulfonyl-benzo[cd]indol-2-one
Authors:Xiao, S., Chen, S., Chen, H.
Deposit date:2018-02-01
Release date:2019-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:BRD4 Bromodomain 1 with an inhibitor
To Be Published
5Z8Z
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BRD4 BROMODOMAIN 1 WITH AN INHIBITOR
Descriptor:Bromodomain-containing protein 4, 6-[(3S)-3-azanylpiperidin-1-yl]sulfonyl-1-ethyl-benzo[cd]indol-2-one
Authors:Xiao, S., Chen, S., Chen, H.
Deposit date:2018-02-01
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:BRD4 Bromodomain 1 with an inhibitor
To Be Published
5Z90
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BRD4 BROMODOMAIN 1 WITH AN INHIBITOR
Descriptor:Bromodomain-containing protein 4, 1-ethyl-6-pyrrolidin-1-ylsulfonyl-benzo[cd]indol-2-one
Authors:Xiao, S., Chen, S., Chen, H.
Deposit date:2018-02-01
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:BRD4 Bromodomain 1 with an inhibitor
To Be Published
5Z9K
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BRD4 BROMODOMAIN 1 WITH AN INHIBITOR
Descriptor:Bromodomain-containing protein 4, 1-ethyl-6-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl-benzo[cd]indol-2-one
Authors:Xiao, S., Chen, S., Chen, H.
Deposit date:2018-02-03
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:BRD4 Bromodomain 1 with an inhibitor
To Be Published
2LSW
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STRUCTURE, SULFATIDE-BINDING PROPERTIES, AND INHIBITION OF PLATELET AGGREGATION BY A DISABLED-2-DERIVED PEPTIDE
Descriptor:Disabled homolog 2
Authors:Xiao, S.
Deposit date:2012-05-08
Release date:2012-09-19
Last modified:2012-11-21
Method:SOLUTION NMR
Cite:Structure, Sulfatide Binding Properties, and Inhibition of Platelet Aggregation by a Disabled-2 Protein-derived Peptide.
J.Biol.Chem., 287, 2012
2N2N
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TOM1 NEGATIVELY MODULATES BINDING OF TOLLIP TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE VIA A COUPLED FOLDING AND BINDING MECHANISM
Descriptor:Target of Myb protein 1
Authors:Xiao, S., Armstrong, G., Capelluto, D.
Deposit date:2015-05-11
Release date:2015-09-16
Last modified:2015-10-21
Method:SOLUTION NMR
Cite:Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
Structure, 23, 2015
2N31
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TOM1 NEGATIVELY MODULATES BINDING OF TOLLIP TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE VIA A COUPLED FOLDING AND BINDING MECHANISM
Descriptor:Toll interacting protein variant
Authors:Xiao, S., Armstrong, G., Capelluto, D.
Deposit date:2015-05-19
Release date:2015-09-16
Last modified:2015-10-21
Method:SOLUTION NMR
Cite:Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
Structure, 23, 2015
2N9D
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STRUCTURE ANALYSIS OF THE TOM1 GAT DOMAIN REVEALS DISTINCT LIGAND-SPECIFIC CONFORMATIONAL STATES
Descriptor:Target of Myb protein 1
Authors:Xiao, S., Jeffrey, E.F., Geoffrey, A.S., Capelluto, D.G.S.
Deposit date:2015-11-15
Release date:2016-09-21
Method:SOLUTION NMR
Cite:Structure of the GAT domain of the endosomal adapter protein Tom1.
Data Brief, 7, 2016
5T7Q
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TIRAP PHOSPHOINOSITIDE-BINDING MOTIF
Descriptor:Toll/interleukin-1 receptor domain-containing adapter protein
Authors:Capelluto, D.G.S., Ellena, J.F., Armstrong, G., Zhao, X., Xiao, S.
Deposit date:2016-09-05
Release date:2017-03-08
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.
Sci Rep, 7, 2017
5KZF
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CRYSTAL STRUCTURE OF NEAR FULL-LENGTH HEXAMERIC MYCOBACTERIUM TUBERCULOSIS PROTEASOMAL ATPASE MPA IN APO FORM
Descriptor:Proteasome-associated ATPase
Authors:Li, H., Hu, K., Yang, S., Bai, L.
Deposit date:2016-07-25
Release date:2017-05-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease.
Mol. Microbiol., 105, 2017
5KWA
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COMPLETE STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS PROTEASOMAL ATPASE MPA
Descriptor:Proteasome-associated ATPase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Wang, T., WU, Y.J.
Deposit date:2016-07-17
Release date:2017-06-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease
Mol. Microbiol., 105, 2017
3QK5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
4QQN
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PROTEIN ARGININE METHYLTRANSFERASE 3 IN COMPLEX WITH COMPOUND MTV044246
Descriptor:PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ...
Authors:Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Luo, X., Chen, Z., Dai, M., Yu, Z., Lin, Y., Zhang, H., Zhao, K., Schapira, M., Brown, P.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-09-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
J. Med. Chem., 61, 2018
4WZF
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CRYSTAL STRUCTURAL BASIS FOR RV0315, AN IMMUNOSTIMULATORY ANTIGEN AND PSEUDO BETA-1, 3-GLUCANASE OF MYCOBACTERIUM TUBERCULOSIS
Descriptor:1,3-beta-glucanase, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Dong, W.Y., Fu, Z.F., Peng, G.Q.
Deposit date:2014-11-19
Release date:2015-12-09
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis.
Sci Rep, 5, 2015
4XFQ
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CRYSTAL STRUCTURE BASIS FOR PEDV 3C LIKE PROTEASE
Descriptor:PEDV main protease
Authors:Ye, G., Fu, Z.F., Peng, G.Q.
Deposit date:2014-12-28
Release date:2016-01-20
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease.
Virology, 494, 2016
4ZUH
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COMPLEX STRUCTURE OF PEDV 3CLPRO MUTANT (C144A) WITH A PEPTIDE SUBSTRATE.
Descriptor:PEDV 3C-Like protease, peptide substrate SAVLQSGF
Authors:Ye, G., Fu, Z.F., Peng, G.Q.
Deposit date:2015-05-16
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease.
Virology, 494, 2016
5Y4L
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PRRSV NSP4
Descriptor:Non-structural protein
Authors:Shi, Y.J., Gang, Y., Peng, G.Q.
Deposit date:2017-08-04
Release date:2018-01-17
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus.
Vet. Microbiol., 213, 2018