4VUB
 
 | | CCDB, A TOPOISOMERASE POISON FROM ESCHERICHIA COLI | | Descriptor: | CCDB, CHLORIDE ION | | Authors: | Loris, R, Dao-Thi, M.-H, Bahasi, E.M, Van Melderen, L, Poortmans, F, Liddington, R, Couturier, M, Wyns, L. | | Deposit date: | 1998-04-17 | | Release date: | 1998-10-14 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal structure of CcdB, a topoisomerase poison from E. coli.
J.Mol.Biol., 285, 1999
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5GSP
 | | RIBONUCLEASE T1/3'-GMP, 9 WEEKS | | Descriptor: | CALCIUM ION, GUANOSINE-3'-MONOPHOSPHATE, RIBONUCLEASE T1 | | Authors: | Zegers, I, Wyns, L. | | Deposit date: | 1997-12-09 | | Release date: | 1998-03-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.
Nat.Struct.Biol., 5, 1998
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3VUB
 | | CCDB, A TOPOISOMERASE POISON FROM E. COLI | | Descriptor: | CCDB, CHLORIDE ION | | Authors: | Loris, R, Dao-Thi, M.-H, Bahasi, E.M, Van Melderen, L, Poortmans, F, Liddington, R, Couturier, M, Wyns, L. | | Deposit date: | 1998-04-17 | | Release date: | 1998-06-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of CcdB, a topoisomerase poison from E. coli.
J.Mol.Biol., 285, 1999
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6GSP
 | | RIBONUCLEASE T1/3'-GMP, 15 WEEKS | | Descriptor: | CALCIUM ION, GUANOSINE-3'-MONOPHOSPHATE, RIBONUCLEASE T1 | | Authors: | Zegers, I, Wyns, L. | | Deposit date: | 1997-12-09 | | Release date: | 1998-03-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.
Nat.Struct.Biol., 5, 1998
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4I0C
 | | The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | | Descriptor: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | | Authors: | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | | Deposit date: | 2012-11-16 | | Release date: | 2013-10-09 | | Last modified: | 2013-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
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7GSP
 | | RIBONUCLEASE T1/2',3'-CGPS, NON-PRODUCTIVE | | Descriptor: | GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, PHOSPHATE ION, RIBONUCLEASE T1 | | Authors: | Zegers, I, Wyns, L. | | Deposit date: | 1997-12-10 | | Release date: | 1998-03-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.
Nat.Struct.Biol., 5, 1998
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2VUB
 | | CCDB, A TOPOISOMERASE POISON FROM E. COLI | | Descriptor: | CCDB, CHLORIDE ION | | Authors: | Loris, R, Dao-Thi, M.-H, Bahasi, E.M, Van Melderen, L, Poortmans, F, Liddington, R, Couturier, M, Wyns, L. | | Deposit date: | 1998-04-21 | | Release date: | 1998-06-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of CcdB, a topoisomerase poison from E. coli.
J.Mol.Biol., 285, 1999
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4GSP
 | | RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS + 3'-GMP, 7 DAYS | | Descriptor: | CALCIUM ION, GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, GUANOSINE-3'-MONOPHOSPHATE, ... | | Authors: | Zegers, I, Wyns, L. | | Deposit date: | 1997-12-02 | | Release date: | 1998-08-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.
Nat.Struct.Biol., 5, 1998
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2VCO
 | | Crystal structure of the fimbrial adhesin FimH in complex with its high-mannose epitope | | Descriptor: | NICKEL (II) ION, PROTEIN FIMH, SULFATE ION, ... | | Authors: | Wellens, A, Garofalo, C, Nguyen, H, Wyns, L, De Greve, H, Hultgren, S.J, Bouckaert, J. | | Deposit date: | 2007-09-26 | | Release date: | 2008-05-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the Fimh-Oligomannose-3 Complex.
Plos One, 3, 2008
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2X89
 | | Structure of the Beta2_microglobulin involved in amyloidogenesis | | Descriptor: | ANTIBODY, BETA-2-MICROGLOBULIN | | Authors: | Domanska, K, Srinivasan, V, Vanderhaegen, S, Pardon, E, Marquez, J.A, Bellotti, V, Wyns, L, Steyaert, J. | | Deposit date: | 2010-03-07 | | Release date: | 2011-01-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2X6M
 | | Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein | | Descriptor: | ALPHA-SYNUCLEIN PEPTIDE, HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY | | Authors: | DeGenst, E, Guilliams, T, Wellens, J, O'Day, E.M, Waudby, C.A, Meehan, S, Dumoulin, M, Hsu, S.-T.D, Cremades, N, Verschueren, K.H.G, Pardon, E, Wyns, L, Steyaert, J, Christodoulou, J, Dobson, C.M. | | Deposit date: | 2010-02-18 | | Release date: | 2010-06-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.
J.Mol.Biol., 402, 2010
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1G7Y
 | | THE CRYSTAL STRUCTURE OF THE 58KD VEGETATIVE LECTIN FROM THE TROPICAL LEGUME DOLICHOS BIFLORUS | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, STEM/LEAF LECTIN DB58, ... | | Authors: | Buts, L, Hamelryck, T.W, Loris, R, Dao-Thi, M.-H, Wyns, L, Etzler, M.E. | | Deposit date: | 2000-11-15 | | Release date: | 2000-11-29 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Weak protein-protein interactions in lectins: the crystal structure of a vegetative lectin from the legume Dolichos biflorus.
J.Mol.Biol., 309, 2001
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3ENR
 | | ZINC-CALCIUM CONCANAVALIN A AT PH 6.15 | | Descriptor: | CALCIUM ION, Concanavalin-A, ZINC ION | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1999-02-11 | | Release date: | 2000-09-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
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1G8W
 | | IMPROVED STRUCTURE OF PHYTOHEMAGGLUTININ-L FROM THE KIDNEY BEAN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LEUCOAGGLUTINATING PHYTOHEMAGGLUTININ, ... | | Authors: | Buts, L, Hamelryck, T.W, Dao-Thi, M, Loris, R, Wyns, L, Etzler, M.E. | | Deposit date: | 2000-11-21 | | Release date: | 2000-12-13 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Weak protein-protein interactions in lectins: the crystal structure of a vegetative lectin from the legume Dolichos biflorus.
J.Mol.Biol., 309, 2001
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1LEM
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1X75
 | | CcdB:GyrA14 complex | | Descriptor: | Cytotoxic protein ccdB, DNA gyrase subunit A | | Authors: | Dao-Thi, M.H, Van Melderen, L, De Genst, E, Wyns, L, Loris, R. | | Deposit date: | 2004-08-13 | | Release date: | 2005-05-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular Basis of Gyrase Poisoning by the Addiction Toxin CcdB
J.Mol.Biol., 348, 2005
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2ENR
 | | CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH CADMIUM HAVING A CADMIUM ION BOUND IN BOTH THE S1 SITE AND THE S2 SITE | | Descriptor: | CADMIUM ION, CONCANAVALIN A | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1998-07-14 | | Release date: | 1999-02-16 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
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2LAL
 | | CRYSTAL STRUCTURE DETERMINATION AND REFINEMENT AT 2.3 ANGSTROMS RESOLUTION OF THE LENTIL LECTIN | | Descriptor: | CALCIUM ION, LENTIL LECTIN (ALPHA CHAIN), LENTIL LECTIN (BETA CHAIN), ... | | Authors: | Loris, R, Steyaert, J, Maes, D, Lisgarten, J, Pickersgill, R, Wyns, L. | | Deposit date: | 1993-06-10 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural analysis of two crystal forms of lentil lectin at 1.8 A resolution.
Proteins, 20, 1994
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2ES4
 | | Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase | | Descriptor: | CALCIUM ION, IODIDE ION, Lipase, ... | | Authors: | Pauwels, K, Wyns, L, Tommassen, J, Savvides, S.N, Van Gelder, P. | | Deposit date: | 2005-10-25 | | Release date: | 2006-03-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of a membrane-based steric chaperone in complex with its lipase substrate.
Nat.Struct.Mol.Biol., 13, 2006
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2FMD
 | | Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin | | Descriptor: | CALCIUM ION, Lectin, MANGANESE (II) ION, ... | | Authors: | Buts, L, Garcia-Pino, A, Wyns, L, Loris, R. | | Deposit date: | 2006-01-09 | | Release date: | 2006-08-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis of carbohydrate recognition by a Man(alpha1-2)Man-specific lectin from Bowringia milbraedii.
Glycobiology, 16, 2006
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2GME
 | | Metal-free (apo) P. angolensis seed lectin | | Descriptor: | SULFATE ION, lectin | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Loris, R. | | Deposit date: | 2006-04-06 | | Release date: | 2006-07-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin.
J.Mol.Biol., 361, 2006
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2GNM
 | | P. angolensis lectin (PAL) treated with EDTA for 39 hours | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, alpha-D-mannopyranose, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Loris, R. | | Deposit date: | 2006-04-10 | | Release date: | 2006-07-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin.
J.Mol.Biol., 361, 2006
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2GMM
 | | Metal-free (apo) P. angolensis seed lectin in complex with Man-alpha(1-2)Man | | Descriptor: | SULFATE ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, lectin | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Loris, R. | | Deposit date: | 2006-04-07 | | Release date: | 2006-07-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin.
J.Mol.Biol., 361, 2006
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2GND
 | | One hour EDTA treatment, P. angolensis lectin | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, alpha-D-mannopyranose, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Loris, R. | | Deposit date: | 2006-04-10 | | Release date: | 2006-07-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin.
J.Mol.Biol., 361, 2006
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2GN3
 | | Metal-free (apo-PAL) in complex with alpha-D-Met-Man | | Descriptor: | SULFATE ION, alpha-D-mannopyranose, lectin, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Loris, R. | | Deposit date: | 2006-04-09 | | Release date: | 2006-07-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin.
J.Mol.Biol., 361, 2006
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