Author results

1HYU
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CRYSTAL STRUCTURE OF INTACT AHPF
Descriptor:ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F, SULFATE ION, CHLORIDE ION, ...
Authors:Wood, Z.A., Poole, L.B., Karplus, P.A.
Deposit date:2001-01-22
Release date:2001-02-14
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of intact AhpF reveals a mirrored thioredoxin-like active site and implies large domain rotations during catalysis.
Biochemistry, 40, 2001
1N8J
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CRYSTAL STRUCTURE OF AHPC WITH ACTIVE SITE CYSTEINE MUTATED TO SERINE (C46S)
Descriptor:Alkyl hydroperoxide reductase C22 protein
Authors:Wood, Z.A., Poole, L.B., Karplus, P.A.
Deposit date:2002-11-20
Release date:2003-04-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling
Science, 300, 2003
2EWN
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ECOLI BIOTIN REPRESSOR WITH CO-REPRESSOR ANALOG
Descriptor:BirA bifunctional protein, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE
Authors:Wood, Z.A., Weaver, L.H., Matthews, B.W.
Deposit date:2005-11-04
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Co-repressor Induced Order and Biotin Repressor Dimerization: A Case for Divergent Followed by Convergent Evolution.
J.Mol.Biol., 357, 2006
4GLL
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CRYSTAL STRUCTURE OF HUMAN UDP-XYLOSE SYNTHASE.
Descriptor:UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GUANIDINE, ...
Authors:Wood, Z.A., Polizzi, S.J.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human UDP-alpha-d-xylose Synthase and Escherichia coli ArnA Conserve a Conformational Shunt That Controls Whether Xylose or 4-Keto-Xylose Is Produced.
Biochemistry, 51, 2012
1T8F
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CRYSTAL STRUCTURE OF PHAGE T4 LYSOZYME MUTANT R14A/K16A/I17A/K19A/T21A/E22A/C54T/C97A
Descriptor:Lysozyme, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:He, M.M., Wood, Z.A., Baase, W.A., Xiao, H., Matthews, B.W.
Deposit date:2004-05-12
Release date:2004-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation.
Protein Sci., 13, 2004
1T8G
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CRYSTAL STRUCTURE OF PHAGE T4 LYSOZYME MUTANT L32A/L33A/T34A/C54T/C97A/E108V
Descriptor:Lysozyme, PHOSPHATE ION, CHLORIDE ION, ...
Authors:He, M.M., Wood, Z.A., Baase, W.A., Xiao, H., Matthews, B.W.
Deposit date:2004-05-12
Release date:2004-10-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation.
Protein Sci., 13, 2004
1YEP
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STRUCTURAL AND BIOCHEMICAL ANALYSIS OF THE LINK BETWEEN ENZYMATIC ACTIVITY AND OLGOMERIZATION IN AHPC, A BACTERIAL PEROXIREDOXIN.
Descriptor:Alkyl hydroperoxide reductase subunit C, SULFATE ION
Authors:Parsonage, D., Youngblood, D.S., Sarma, G.N., Wood, Z.A., Karplus, P.A., Poole, L.B.
Deposit date:2004-12-28
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
1YEX
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STRUCTURAL AND BIOCHEMICAL ANALYSIS OF THE LINK BETWEEN ENZYMATIC ACTIVITY AND OLIGOMERIZATION IN AHPC, A BACTERIAL PEROXIREDOXIN.
Descriptor:Alkyl hydroperoxide reductase subunit C, SULFATE ION
Authors:Parsonage, D., Youngblood, D.S., Sarma, G.N., Wood, Z.A., Karplus, P.A., Poole, L.B.
Deposit date:2004-12-28
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
1YF0
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STRUCTURAL AND BIOCHEMICAL ANALYSIS OF THE LINK BETWEEN ENZYMATIC ACTIVITY AND OLIGOMERIZATION IN AHPC, A BACTERIAL PEROXIREDOXIN.
Descriptor:Alkyl hydroperoxide reductase subunit C, SULFATE ION
Authors:Parsonage, D., Youngblood, D.S., Sarma, G.N., Wood, Z.A., Karplus, P.A., Poole, L.B.
Deposit date:2004-12-29
Release date:2005-08-16
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
1YF1
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STRUCTURAL AND BIOCHEMICAL ANALYSIS OF THE LINK BETWEEN ENZYMATIC ACTIVITY AND OLIGOMERIZATION IN AHPC, A BACTERIAL PEROXIREDOXIN.
Descriptor:Alkyl hydroperoxide reductase subunit C, SODIUM ION
Authors:Parsonage, D., Youngblood, D.S., Sarma, G.N., Wood, Z.A., Karplus, P.A., Poole, L.B.
Deposit date:2004-12-29
Release date:2005-08-16
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
1ZYN
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OXIDIZED STRUCTURE OF THE N-TERMINAL DOMAIN OF SALMONELLA TYPHIMURIUM AHPF
Descriptor:Alkyl hydroperoxide reductase subunit F
Authors:Roberts, B.R., Wood, Z.A., Jonsson, T.J., Poole, L.B., Karplus, P.A.
Deposit date:2005-06-10
Release date:2005-06-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF
Protein Sci., 14, 2005
1ZYP
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SYNCHROTRON REDUCED FORM OF THE N-TERMINAL DOMAIN OF SALMONELLA TYPHIMURIUM AHPF
Descriptor:Alkyl hydroperoxide reductase subunit F
Authors:Roberts, B.R., Wood, Z.A., Jonsson, T.J., Poole, L.B., Karplus, P.A.
Deposit date:2005-06-10
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF
Protein Sci., 14, 2005
3PRJ
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ROLE OF PACKING DEFECTS IN THE EVOLUTION OF ALLOSTERY AND INDUCED FIT IN HUMAN UDP-GLUCOSE DEHYDROGENASE.
Descriptor:UDP-glucose 6-dehydrogenase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE-XYLOPYRANOSE
Authors:Kadirvelraj, R., Wood, Z.A.
Deposit date:2010-11-29
Release date:2011-06-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose Dehydrogenase.
Biochemistry, 50, 2011
3PTZ
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ROLE OF PACKING DEFECTS IN THE EVOLUTION OF ALLOSTERY AND INDUCED FIT IN HUMAN UDP-GLUCOSE DEHYDROGENASE.
Descriptor:UDP-glucose 6-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE-XYLOPYRANOSE
Authors:Kadirvelraj, R., Wood, Z.A.
Deposit date:2010-12-03
Release date:2011-06-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose Dehydrogenase.
Biochemistry, 50, 2011
3TF5
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STRUCTURE OF UDP-GLUCOSE DEHYDROGENASE V132 DELETION
Descriptor:UDP-glucose 6-dehydrogenase
Authors:Sennett, N.C., Wood, Z.A.
Deposit date:2011-08-15
Release date:2011-10-12
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational flexibility in the allosteric regulation of human UDP-{alpha}-D-glucose 6-dehydrogenase.
Biochemistry, 50, 2011
4EDF
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DIMERIC HUGDH, K94E
Descriptor:UDP-glucose 6-dehydrogenase, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Sennett, N.C., Wood, Z.A.
Deposit date:2012-03-27
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Cofactor binding triggers a molecular switch to allosterically activate human UDP-{alpha}-D-glucose 6-dehydrogenase.
Biochemistry, 51, 2012
4LK3
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CRYSTAL STRUCTURE OF HUMAN UDP-XYLOSE SYNTHASE R236A SUBSTITUTION
Descriptor:UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE, ...
Authors:Walsh Jr., R.M., Polizzi, S.J., Wood, Z.A.
Deposit date:2013-07-05
Release date:2013-08-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.
Biochemistry, 54, 2015
4M55
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CRYSTAL STRUCTURE OF HUMAN UDP-XYLOSE SYNTHASE R236H SUBSTITUTION
Descriptor:UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYROPHOSPHATE 2-, ...
Authors:Walsh Jr., R.M., Polizzi, S.J., Wood, Z.A.
Deposit date:2013-08-08
Release date:2013-08-28
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.
Biochemistry, 54, 2015
4RJT
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CRYSTAL STRUCTURE OF UNLIGANDED, FULL LENGTH HUGDH AT PH 7.0
Descriptor:UDP-glucose 6-dehydrogenase, CHLORIDE ION
Authors:Sidlo, A.M., Wood, Z.A.
Deposit date:2014-10-09
Release date:2014-12-31
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Hysteresis in Human UDP-Glucose Dehydrogenase Is Due to a Restrained Hexameric Structure That Favors Feedback Inhibition.
Biochemistry, 53, 2014
4S3M
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EVIDENCE OF KINETIC COOPERATIVITY IN DIMERIC KETOPANTOATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:2-dehydropantoate 2-reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sanchez, J.E., Walsh Jr., R.M., Wood, Z.A.
Deposit date:2015-02-19
Release date:2015-03-11
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus.
Biochemistry, 54, 2015
4YCA
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EVIDENCE OF KINETIC COOPERATIVITY IN DIMERIC KETOPANTOATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:2-dehydropantoate 2-reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sanchez, J.E., Gross, P.G., Goetze, R., Walsh Jr., R.M., Peeples, W.B., Wood, Z.A.
Deposit date:2015-02-19
Release date:2015-03-11
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus.
Biochemistry, 54, 2015
5TJH
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HUGDH A136M SUBSTITUTION
Descriptor:UDP-glucose 6-dehydrogenase, PYROPHOSPHATE 2-, CHLORIDE ION, ...
Authors:Beattie, N.R., Wood, Z.A.
Deposit date:2016-10-04
Release date:2016-11-02
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase.
Biochemistry, 56, 2017
5VCM
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ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE WITH BOUND UDP AND MANGANESE
Descriptor:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Sanders, J.H., Kadirvelraj, R., Wood, Z.A.
Deposit date:2017-03-31
Release date:2018-04-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5VCR
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ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE WITH BOUND URANIUM DIOXIDE
Descriptor:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, URANYL (VI) ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sanders, J.H., Kadirvelraj, R., Wood, Z.A.
Deposit date:2017-03-31
Release date:2018-04-11
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5VCS
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ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE WITH BOUND ACCEPTOR
Descriptor:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Sanders, J.H., Kadirvelraj, R., Wood, Z.A.
Deposit date:2017-03-31
Release date:2018-04-11
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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