Author results

1APL
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CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS
Descriptor:DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN)
Authors:Wolberger, C., Vershon, A.K., Liu, B., Johnson, A.D., Pabo, C.O.
Deposit date:1993-10-04
Release date:1993-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 67, 1991
4WA6
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STRUCTURE OF YEAST SAGA DUBM WITH SGF73 N59D MUTANT AT 2.36 ANGSTROMS RESOLUTION
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8, Transcription and mRNA export factor SUS1, SAGA-associated factor 11, ...
Authors:Wolberger, C., Yan, M.
Deposit date:2014-08-28
Release date:2015-03-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution
To Be Published
2GMI
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MMS2/UBC13~UBIQUITIN
Descriptor:Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2, Ubiquitin
Authors:Wolberger, C., Eddins, M.J., Carlile, C.M., Gomez, K.G., Pickart, C.M.
Deposit date:2006-04-06
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
3PDH
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STRUCTURE OF SIR2TM BOUND TO A PROPIONYLATED PEPTIDE
Descriptor:NAD-dependent deacetylase, Cellular tumor antigen p53 18-residue peptide, ZINC ION
Authors:Wolberger, C., Bheda, P.
Deposit date:2010-10-22
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Sir2Tm bound to a propionylated peptide.
Protein Sci., 20, 2011
4W4U
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STRUCTURE OF YEAST SAGA DUBM WITH SGF73 Y57A MUTANT AT 2.8 ANGSTROMS RESOLUTION
Descriptor:Ubiquitin carboxyl-terminal hydrolase, Transcription and mRNA export factor SUS1, SAGA-associated factor 11, ...
Authors:Wolberger, C., Yan, M.
Deposit date:2014-08-15
Release date:2015-07-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.
J.Mol.Biol., 427, 2015
5H84
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HUMAN GCN5 BOUND TO PROPIONYL-COA
Descriptor:Histone acetyltransferase KAT2A, propionyl Coenzyme A, 1,2-ETHANEDIOL, ...
Authors:Wolberger, C., Ringel, A.E.
Deposit date:2015-12-23
Release date:2016-03-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
5H86
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HUMAN GCN5 BOUND TO BUTYRYL-COA
Descriptor:Histone acetyltransferase KAT2A, Butyryl Coenzyme A, 1,2-ETHANEDIOL
Authors:Wolberger, C., Ringel, A.E.
Deposit date:2015-12-23
Release date:2016-03-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
1AKH
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MAT A1/ALPHA2/DNA TERNARY COMPLEX
Descriptor:DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MATING-TYPE PROTEIN A-1), ...
Authors:Li, T., Jin, Y., Vershon, A.K., Wolberger, C.
Deposit date:1997-05-19
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract.
Nucleic Acids Res., 26, 1998
1YRN
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CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2 HOMEODOMAIN HETERODIMER BOUND TO DNA
Descriptor:DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*TP*AP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*TP*AP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT A1 HOMEODOMAIN), ...
Authors:Li, T., Stark, M.R., Johnson, A.D., Wolberger, C.
Deposit date:1995-11-02
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA.
Science, 270, 1995
1JAT
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MMS2/UBC13 UBIQUITIN CONJUGATING ENZYME COMPLEX
Descriptor:Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2
Authors:VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M., Wolberger, C.
Deposit date:2001-05-31
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
1JBB
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UBIQUITIN CONJUGATING ENZYME, UBC13
Descriptor:ubiquitin conjugating enzyme E2-17.5 KDA
Authors:VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M., Wolberger, C.
Deposit date:2001-06-03
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
4TWI
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THE STRUCTURE OF SIR2AF1 BOUND TO A SUCCINYLATED HISTONE PEPTIDE
Descriptor:NAD-dependent protein deacylase 1, Succinylated H4 Peptide (aa8-20), ZINC ION, ...
Authors:Ringel, A.E., Roman, C., Wolberger, C.
Deposit date:2014-06-30
Release date:2014-12-03
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
4TWJ
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THE STRUCTURE OF SIR2AF2 BOUND TO A MYRISTOYLATED HISTONE PEPTIDE
Descriptor:NAD-dependent protein deacylase 2, Histone H4 peptide, ZINC ION, ...
Authors:Ringel, A.E., Roman, C., Wolberger, C.
Deposit date:2014-06-30
Release date:2014-12-03
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
4DHI
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STRUCTURE OF C. ELEGANS OTUB1 BOUND TO HUMAN UBC13
Descriptor:Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N
Authors:Wiener, R., Zhang, X., Wang, T., Wolberger, C.
Deposit date:2012-01-27
Release date:2012-02-22
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The mechanism of OTUB1-mediated inhibition of ubiquitination.
Nature, 483, 2012
1AWC
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MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA
Descriptor:DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3'), PROTEIN (GA BINDING PROTEIN ALPHA), ...
Authors:Batchelor, A.H., Wolberger, C.
Deposit date:1997-10-01
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Science, 279, 1998
1B72
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PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX
Descriptor:DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ...
Authors:Piper, D.E., Batchelor, A.H., Chang, C.-P., Cleary, M.L., Wolberger, C.
Deposit date:1999-01-27
Release date:1999-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
Cell(Cambridge,Mass.), 96, 1999
1ERJ
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CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1
Descriptor:TRANSCRIPTIONAL REPRESSOR TUP1
Authors:Sprague, E.R., Redd, M.J., Johnson, A.D., Wolberger, C.
Deposit date:2000-04-06
Release date:2000-07-26
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J., 19, 2000
1K61
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MATALPHA2 HOMEODOMAIN BOUND TO DNA
Descriptor:5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*CP*AP*CP*GP*C)-3', 5'-D(*(5IU)P*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*AP*CP*AP*TP*G)-3', Mating-type protein alpha-2
Authors:Aishima, J., Gitti, R.K., Noah, J.E., Gan, H.H., Schlick, T., Wolberger, C.
Deposit date:2001-10-14
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Hoogsteen base pair embedded in undistorted B-DNA
NUCLEIC ACIDS RES., 30, 2002
1K78
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PAX5(1-149)+ETS-1(331-440)+DNA
Descriptor:Pax5/Ets Binding Site on the mb-1 promoter, Paired Box Protein Pax5, C-ets-1 Protein
Authors:Garvie, C.W., Hagman, J., Wolberger, C.
Deposit date:2001-10-18
Release date:2002-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
1K79
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ETS-1(331-440)+GGAA DUPLEX
Descriptor:DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*AP*AP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*CP*AP*TP*TP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), C-ets-1 protein
Authors:Garvie, C.W., Hagman, J., Wolberger, C.
Deposit date:2001-10-18
Release date:2002-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
1K7A
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ETS-1(331-440)+GGAG DUPLEX
Descriptor:DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*GP*AP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*CP*AP*TP*CP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), C-ets-1 Protein
Authors:Garvie, C.W., Hagman, J., Wolberger, C.
Deposit date:2001-10-18
Release date:2002-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
1LE8
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CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2-3A HETERODIMER BOUND TO DNA COMPLEX
Descriptor:5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*CP*AP*TP*CP*A)-3', 5'-D(*TP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*AP*CP*AP*TP*G)-3', MATING-TYPE PROTEIN A-1, ...
Authors:Ke, A., Mathias, J.R., Vershon, A.K., Wolberger, C.
Deposit date:2002-04-09
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATalpha2
Structure, 10, 2002
1MA3
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STRUCTURE OF A SIR2 ENZYME BOUND TO AN ACETYLATED P53 PEPTIDE
Descriptor:Transcriptional regulatory protein, Sir2 family, Cellular tumor antigen p53, ...
Authors:Avalos, J.L., Celic, I., Muhammad, S., Cosgrove, M.S., Boeke, J.D., Wolberger, C.
Deposit date:2002-07-31
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a Sir2 enzyme bound to an acetylated p53 peptide
Mol.Cell, 10, 2002
1MD0
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CRYSTAL STRUCTURE OF AN INHIBITED FRAGMENT OF ETS-1
Descriptor:C-ets-1 protein
Authors:Garvie, C.W., Pufall, M.A., Graves, B.J., Wolberger, C.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships
J.Biol.Chem., 277, 2002
1MDM
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INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA
Descriptor:PAX5/ETS BINDING SITE ON THE MB-1 PROMOTER, PAIRED BOX PROTEIN PAX-5, C-ETS-1 PROTEIN
Authors:Garvie, C.W., Pufall, M.A., Graves, B.J., Wolberger, C.
Deposit date:2002-08-07
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:STRUCTURAL ANALYSIS OF THE AUTOINHIBITION OF ETS-1 AND ITS ROLE IN PROTEIN PARTNERSHIPS
J.Biol.Chem., 277, 2002
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