Author results

5WL2
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VH1-69 GERMLINE ANTIBODY WITH CDR H3 SEQUENCE OF CR9114
Descriptor:Heavy chain of VH1-69 germline antibody with CDR H3 sequence of CR9114, Germline-reverted light chain of CR9114
Authors:Wilson, I.A., Lang, S.
Deposit date:2017-07-25
Release date:2018-08-01
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem.
To Be Published
1GAR
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TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID
Authors:Wilson, I.A., Klein, C., Chen, P., Arevalo, J.H.
Deposit date:1994-12-08
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
J.Mol.Biol., 249, 1995
1KQ3
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CRYSTAL STRUCTURE OF A GLYCEROL DEHYDROGENASE (TM0423) FROM THERMOTOGA MARITIMA AT 1.5 A RESOLUTION
Descriptor:glycerol dehydrogenase, ZINC ION, CHLORIDE ION, ...
Authors:Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
Deposit date:2002-01-03
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
1KQ4
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CRYSTAL STRUCTURE OF A THY1-COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA AT 2.25 A RESOLUTION
Descriptor:HYPOTHETICAL PROTEIN TM0449, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
Deposit date:2002-01-03
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
1ZIW
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HUMAN TOLL-LIKE RECEPTOR 3 EXTRACELLULAR DOMAIN STRUCTURE
Descriptor:Toll-like receptor 3, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Choe, J.
Deposit date:2005-04-27
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Science, 309, 2005
5CEY
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CRYSTAL STRUCTURE OF FAB 9H+3L, A PUTATIVE PRECURSOR OF THE PGT121 FAMILY OF POTENT HIV-1 ANTIBODIES
Descriptor:Antibody 9H+3L Fab light chain, Antibody 9H+3L Fab heavy chain, GLYCEROL, ...
Authors:Wilson, I.A., Garces, F.
Deposit date:2015-07-07
Release date:2015-12-23
Last modified:2016-01-06
Method:X-RAY DIFFRACTION (2.387 Å)
Cite:Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity, 43, 2015
5CEZ
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CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV-1 ENV TRIMER IN COMPLEX WITH AN EARLY PUTATIVE PRECURSOR OF THE PGT121 FAMILY AT 3.0 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 3H+109L Fab Light Chain, 3H+109L Fab Heavy Chain, ...
Authors:Wilson, I.A., Garces, F.
Deposit date:2015-07-08
Release date:2015-12-23
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.031 Å)
Cite:Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity, 43, 2015
5T08
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS
Descriptor:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Tzarum, N., Zhu, X.
Deposit date:2016-08-15
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1895 Å)
Cite:A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0B
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH 6'-SLN
Descriptor:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Tzarum, N., Zhu, X.
Deposit date:2016-08-15
Release date:2017-06-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0D
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH 3'-SLN
Descriptor:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Tzarum, N., Zhu, X.
Deposit date:2016-08-15
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.864 Å)
Cite:A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0E
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH LSTA
Descriptor:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Tzarum, N., Zhu, X.
Deposit date:2016-08-15
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.089 Å)
Cite:A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5TG8
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CRYSTAL STRUCTURE OF H15 HEMAGGLUTININ FROM A/SHEARWATER/WA/2576/1979 H15N9 INFLUENZA VIRUS
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Tzarum, N.
Deposit date:2016-09-27
Release date:2017-04-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Unique Structural Features of Influenza Virus H15 Hemagglutinin.
J. Virol., 91, 2017
5TG9
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CRYSTAL STRUCTURE OF H15 HEMAGGLUTININ FROM A/SHEARWATER/WA/2576/1979 H15N9 INFLUENZA VIRUS IN COMPLEX WITH 3'-SLN
Descriptor:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Tzarum, N.
Deposit date:2016-09-27
Release date:2017-04-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.749 Å)
Cite:Unique Structural Features of Influenza Virus H15 Hemagglutinin.
J. Virol., 91, 2017
5W5S
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141019 (P5)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-ZCL-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-15
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.284 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W5U
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141037 (P4)
Descriptor:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.461 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6I
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141046 (P3)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6R
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141099 (P6)
Descriptor:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.731 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6T
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP151070 (P7)
Descriptor:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-ZCL-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6U
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP121068 (P2)
Descriptor:Hemagglutinin, ACE-ARG-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2017-06-16
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.878 Å)
Cite:Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
6CEX
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CRYSTAL STRUCTURE OF THE A/HONG KONG/1/1968 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE N-CYCLOHEXYLTAURINE
Descriptor:Hemagglutinin, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:wilson, I.A., Kadam, R.U.
Deposit date:2018-02-12
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CF5
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CRYSTAL STRUCTURE OF THE A/VIET NAM/1203/2004(H5N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE N-CYCLOHEXYLTAURINE
Descriptor:Hemagglutinin, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wilson, I.A., Kadam, R.U.
Deposit date:2018-02-13
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MU3
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ANTI-HIV-1 FAB 2G12 + MAN7 RE-REFINEMENT
Descriptor:Fab 2G12, light chain, heavy chain, ...
Authors:Wilson, I.A., Calarese, D.A., Stanfield, R.L.
Deposit date:2018-10-22
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.327 Å)
Cite:Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proc. Natl. Acad. Sci. U.S.A., 102, 2005
6MUB
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ANTI-HIV-1 FAB 2G12 + MAN5 RE-REFINEMENT
Descriptor:Fab 2G12, light chain, heavy chain, ...
Authors:Wilson, I.A., Calarese, D.A., Stanfield, R.L.
Deposit date:2018-10-22
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proc. Natl. Acad. Sci. U.S.A., 102, 2005
2B1G
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2005-09-15
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2B1I
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
Authors:Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2005-09-15
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007