Author results

5WL2
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VH1-69 GERMLINE ANTIBODY WITH CDR H3 SEQUENCE OF CR9114
分子名称:Heavy chain of VH1-69 germline antibody with CDR H3 sequence of CR9114, Germline-reverted light chain of CR9114
著者Wilson, I.A., Lang, S.
登録日2017-07-25
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem.
To Be Published
1GAR
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TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION
分子名称:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID
著者Wilson, I.A., Klein, C., Chen, P., Arevalo, J.H.
登録日1994-12-08
公開日1995-07-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
J.Mol.Biol., 249, 1995
1KQ3
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CRYSTAL STRUCTURE OF A GLYCEROL DEHYDROGENASE (TM0423) FROM THERMOTOGA MARITIMA AT 1.5 A RESOLUTION
分子名称:glycerol dehydrogenase, ZINC ION, CHLORIDE ION, ...
著者Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
登録日2002-01-03
公開日2002-02-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
1KQ4
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CRYSTAL STRUCTURE OF A THY1-COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA AT 2.25 A RESOLUTION
分子名称:HYPOTHETICAL PROTEIN TM0449, FLAVIN-ADENINE DINUCLEOTIDE
著者Wilson, I.A., Miller, M.D., Joint Center for Structural Genomics (JCSG)
登録日2002-01-03
公開日2002-02-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Proc.Natl.Acad.Sci.USA, 99, 2002
1ZIW
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HUMAN TOLL-LIKE RECEPTOR 3 EXTRACELLULAR DOMAIN STRUCTURE
分子名称:Toll-like receptor 3, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Choe, J.
登録日2005-04-27
公開日2005-06-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Science, 309, 2005
5CEY
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CRYSTAL STRUCTURE OF FAB 9H+3L, A PUTATIVE PRECURSOR OF THE PGT121 FAMILY OF POTENT HIV-1 ANTIBODIES
分子名称:Antibody 9H+3L Fab light chain, Antibody 9H+3L Fab heavy chain, GLYCEROL, ...
著者Wilson, I.A., Garces, F.
登録日2015-07-07
公開日2015-12-23
最終更新日2016-01-06
実験手法X-RAY DIFFRACTION (2.387 Å)
主引用文献Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity, 43, 2015
5CEZ
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CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV-1 ENV TRIMER IN COMPLEX WITH AN EARLY PUTATIVE PRECURSOR OF THE PGT121 FAMILY AT 3.0 ANGSTROM
分子名称:Envelope glycoprotein gp160, 3H+109L Fab Light Chain, 3H+109L Fab Heavy Chain, ...
著者Wilson, I.A., Garces, F.
登録日2015-07-08
公開日2015-12-23
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (3.031 Å)
主引用文献Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity, 43, 2015
5T08
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS
分子名称:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE
著者Wilson, I.A., Tzarum, N., Zhu, X.
登録日2016-08-15
公開日2017-06-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.1895 Å)
主引用文献A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0B
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH 6'-SLN
分子名称:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Tzarum, N., Zhu, X.
登録日2016-08-15
公開日2017-06-14
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0D
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH 3'-SLN
分子名称:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Tzarum, N., Zhu, X.
登録日2016-08-15
公開日2017-06-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.864 Å)
主引用文献A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5T0E
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CRYSTAL STRUCTURE OF H6 HEMAGGLUTININ G225D MUTANT FROM TAIWAN (2013) H6N1 INFLUENZA VIRUS IN COMPLEX WITH LSTA
分子名称:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Tzarum, N., Zhu, X.
登録日2016-08-15
公開日2017-06-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.089 Å)
主引用文献A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
EMBO Mol Med, 9, 2017
5TG8
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CRYSTAL STRUCTURE OF H15 HEMAGGLUTININ FROM A/SHEARWATER/WA/2576/1979 H15N9 INFLUENZA VIRUS
分子名称:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE
著者Wilson, I.A., Tzarum, N.
登録日2016-09-27
公開日2017-04-12
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Unique Structural Features of Influenza Virus H15 Hemagglutinin.
J. Virol., 91, 2017
5TG9
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CRYSTAL STRUCTURE OF H15 HEMAGGLUTININ FROM A/SHEARWATER/WA/2576/1979 H15N9 INFLUENZA VIRUS IN COMPLEX WITH 3'-SLN
分子名称:Hemagglutinin, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Tzarum, N.
登録日2016-09-27
公開日2017-04-12
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.749 Å)
主引用文献Unique Structural Features of Influenza Virus H15 Hemagglutinin.
J. Virol., 91, 2017
5W5S
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141019 (P5)
分子名称:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-ZCL-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-15
公開日2017-10-04
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.284 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W5U
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141037 (P4)
分子名称:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-15
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.461 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6I
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141046 (P3)
分子名称:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-16
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6R
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP141099 (P6)
分子名称:Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-16
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.731 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6T
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP151070 (P7)
分子名称:Hemagglutinin, ACE-PH8-ORN-MLE-GLU-TYR-ZCL-GLU-TRP-LEU-SER-9WV, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-16
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
5W6U
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CRYSTAL STRUCTURE OF THE A/PUERTO RICO/8/1934 (H1N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH CYCLIC PEPTIDE CP121068 (P2)
分子名称:Hemagglutinin, ACE-ARG-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, N-ACETYL-D-GLUCOSAMINE
著者Wilson, I.A., Kadam, R.U.
登録日2017-06-16
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.878 Å)
主引用文献Potent peptidic fusion inhibitors of influenza virus.
Science, 358, 2017
6CEX
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CRYSTAL STRUCTURE OF THE A/HONG KONG/1/1968 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE N-CYCLOHEXYLTAURINE
分子名称:Hemagglutinin, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
著者wilson, I.A., Kadam, R.U.
登録日2018-02-12
公開日2018-04-04
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CF5
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CRYSTAL STRUCTURE OF THE A/VIET NAM/1203/2004(H5N1) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH SMALL MOLECULE N-CYCLOHEXYLTAURINE
分子名称:Hemagglutinin, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
著者Wilson, I.A., Kadam, R.U.
登録日2018-02-13
公開日2018-04-04
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MU3
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ANTI-HIV-1 FAB 2G12 + MAN7 RE-REFINEMENT
分子名称:Fab 2G12, light chain, heavy chain, ...
著者Wilson, I.A., Calarese, D.A., Stanfield, R.L.
登録日2018-10-22
公開日2018-10-31
実験手法X-RAY DIFFRACTION (2.327 Å)
主引用文献Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proc. Natl. Acad. Sci. U.S.A., 102, 2005
6MUB
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ANTI-HIV-1 FAB 2G12 + MAN5 RE-REFINEMENT
分子名称:Fab 2G12, light chain, heavy chain, ...
著者Wilson, I.A., Calarese, D.A., Stanfield, R.L.
登録日2018-10-22
公開日2018-10-31
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proc. Natl. Acad. Sci. U.S.A., 102, 2005
2B1G
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, POTASSIUM ION, ...
著者Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2B1I
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
分子名称:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
著者Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007