Author results

1P7Q
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CRYSTAL STRUCTURE OF HLA-A2 BOUND TO LIR-1, A HOST AND VIRAL MHC RECEPTOR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Willcox, B.E., Thomas, L.M., Bjorkman, P.J.
Deposit date:2003-05-05
Release date:2003-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor.
Nat.Immunol., 4, 2003
2GW5
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CRYSTAL STRUCTURE OF LIR-2 (ILT4) AT 1.8 : DIFFERENCES FROM LIR-1 (ILT2) IN REGIONS IMPLICATED IN THE BINDING OF THE CYTOMEGALOVIRUS CLASS I MHC HOMOLOG UL18
Descriptor:Leukocyte immunoglobulin-like receptor subfamily B member 2 precursor, ISOPROPYL ALCOHOL
Authors:Willcox, B.E., Thomas, L.M., Chapman, T.L., Heikema, A.P., West, A.P., Bjorkman, P.J.
Deposit date:2006-05-03
Release date:2006-06-20
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18.
Bmc Struct.Biol., 2, 2002
2N4I
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THE SOLUTION STRUCTURE OF SKINT-1, A CRITICAL DETERMINANT OF DENDRITIC EPIDERMAL GAMMA-DELTA T CELL SELECTION
Descriptor:Selection and upkeep of intraepithelial T-cells protein 1
Authors:Salim, M., Knowles, T.J., Hart, R., Mohammed, F., Woodward, M.J., Willcox, C.R., Overduin, M., Hayday, A.C., Willcox, B.E.
Deposit date:2015-06-18
Release date:2016-03-02
Last modified:2016-05-11
Method:SOLUTION NMR
Cite:Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.
J.Biol.Chem., 291, 2016
1MHE
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THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN HLA-E, BETA-2-MICROGLOBULIN, PEPTIDE (VMAPRTVLL), ...
Authors:O'Callaghan, C.A., Tormo, J., Willcox, B.E., Braud, V.B., Jakobsen, B.K., Stuart, D.I., Mcmichael, A.J., Bell, J.I., Jones, E.Y.
Deposit date:1998-08-24
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
Mol.Cell, 1, 1998
4NNX
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CRYSTAL STRUCTURE OF PKD2 PHOSPHOPEPTIDE BOUND TO HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-11-19
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4NNY
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CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF PKD2 PHOSPHOPEPTIDE BOUND TO HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-11-19
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4NO0
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CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF RQA_V PHOSPHOPEPTIDE BOUND TO HLA-A2 IN COMPLEX WITH LILRB1
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-11-19
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4NO2
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CRYSTAL STRUCTURE OF RQA_V PHOSPHOPEPTIDE BOUND TO HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-11-19
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4NO3
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CRYSTAL STRUCTURE OF AMPD2 PHOSPHOPEPTIDE BOUND TO HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-12-24
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4NO5
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CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF AMPD2 PHOSPHOPEPTIDE BOUND TO HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2013-11-19
Release date:2014-12-24
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
4S0U
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CRYSTAL STRUCTURE OF NKG2D IN COMPLEX WITH ULBP6
Descriptor:NKG2-D type II integral membrane protein, Retinoic acid early transcript 1L protein
Authors:Mohammed, F., Willcox, B.E.
Deposit date:2015-01-06
Release date:2016-04-20
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.
Sci Signal, 10, 2017
5LYG
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 BOUND TO MALONATE
Descriptor:Butyrophilin subfamily 3 member A1, 1,2-ETHANEDIOL, MALONATE ION
Authors:Mohammed, F., Baker, A.T., Salim, M., Willcox, B.E.
Deposit date:2016-09-28
Release date:2017-09-13
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:BTN3A1 Discriminates gamma delta T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.
ACS Chem. Biol., 12, 2017
5LYK
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 BOUND TO CITRATE
Descriptor:Butyrophilin subfamily 3 member A1, CITRATE ANION, 1,2-ETHANEDIOL
Authors:Mohammed, F., Baker, A.T., Salim, M., Willcox, B.E.
Deposit date:2016-09-28
Release date:2017-09-13
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:BTN3A1 Discriminates gamma delta T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.
ACS Chem. Biol., 12, 2017
3BGM
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CRYSTAL STRUCTURE OF PKD2 PHOSPHOPEPTIDE BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Cobbold, M., Zarling, A.L., Salim, M., Barrett-Wilt, G.A., Shabanowitz, J., Hunt, D.F., Engelhard, V.H., Willcox, B.E.
Deposit date:2007-11-27
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self
Nat.Immunol., 9, 2008
3BH8
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CRYSTAL STRUCTURE OF RQA_M PHOSPHOPEPTIDE BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Cobbold, M., Zarling, A.L., Salim, M., Barrett-Wilt, G.A., Shabanowitz, J., Hunt, D.F., Engelhard, V.H., Willcox, B.E.
Deposit date:2007-11-28
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self
Nat.Immunol., 9, 2008
3BH9
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CRYSTAL STRUCTURE OF RTY PHOSPHOPEPTIDE BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Cobbold, M., Zarling, A.L., Salim, M., Barrett-Wilt, G.A., Shabanowitz, J., Hunt, D.F., Engelhard, V.H., Willcox, B.E.
Deposit date:2007-11-28
Release date:2008-10-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self
Nat.Immunol., 9, 2008
3BHB
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CRYSTAL STRUCTURE OF KMD PHOSPHOPEPTIDE BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Cobbold, M., Zarling, A.L., Salim, M., Barrett-Wilt, G.A., Shabanowitz, J., Hunt, D.F., Engelhard, V.H., Willcox, B.E.
Deposit date:2007-11-28
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self
Nat.Immunol., 9, 2008
3D25
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CRYSTAL STRUCTURE OF HA-1 MINOR HISTOCOMPATIBILITY ANTIGEN BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Nicholls, S., Piper, K.P., Mohammed, F., Dafforn, T.R., Tenzer, S., Salim, M., Mahendra, P., Craddock, C., van Endert, P., Schild, H., Cobbold, M., Engelhard, V.H., Moss, P.A.H., Willcox, B.E.
Deposit date:2008-05-07
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition
Proc.Natl.Acad.Sci.USA, 106, 2009
3P2T
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CRYSTAL STRUCTURE OF LEUKOCYTE IG-LIKE RECEPTOR LILRB4 (ILT3/LIR-5/CD85K)
Descriptor:Leukocyte immunoglobulin-like receptor subfamily B member 4, SULFATE ION
Authors:Chen, Y., Nam, G., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.
Deposit date:2010-10-04
Release date:2011-03-30
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance
J.Biol.Chem., 286, 2011
3REV
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CRYSTAL STRUCTURE OF HUMAN ALLOREACTIVE TCR NB20
Descriptor:TCR NB20 ALPHA CHAIN, TCR NB20 BETA CHAIN, 1,2-ETHANEDIOL
Authors:Wood, A., Mohammed, F., Salim, M., Tranter, A., Rickinson, A.B., Moss, P.A.H., Stauss, H.J., Steven, N.M., Willcox, B.E.
Deposit date:2011-04-05
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.
Proc.Natl.Acad.Sci.USA, 108, 2011
3REW
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CRYSTAL STRUCTURE OF AN LMP2A-DERIVED PEPTIDE BOUND TO HUMAN CLASS I MHC HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Wood, A., Mohammed, F., Salim, M., Tranter, A., Rickinson, A.B., Moss, P.A.H., Stauss, H.J., Steven, N.M., Willcox, B.E.
Deposit date:2011-04-05
Release date:2012-01-18
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.
Proc.Natl.Acad.Sci.USA, 108, 2011
6EWA
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CRYSTAL STRUCTURE OF HLA-A2 IN COMPLEX WITH LILRB1
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Stones, D.H., Willcox, B.E., Mohammed, F.
Deposit date:2017-11-03
Release date:2018-11-07
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Application of the immunoregulatory receptor LILRB1 as a crystallisation chaperone for human class I MHC complexes.
J. Immunol. Methods, 464, 2019
6EWC
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CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF RLS PHOSPHOPEPTIDE BOUND TO HLA-A2 IN COMPLEX WITH LILRB1
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2017-11-03
Release date:2018-11-07
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Application of the immunoregulatory receptor LILRB1 as a crystallisation chaperone for human class I MHC complexes.
J. Immunol. Methods, 464, 2019
6EWO
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CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF RTF PHOSPHOPEPTIDE BOUND TO HLA-A2 IN COMPLEX WITH LILRB1
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Mohammed, F., Stones, D.H., Willcox, B.E.
Deposit date:2017-11-06
Release date:2018-11-07
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Application of the immunoregulatory receptor LILRB1 as a crystallisation chaperone for human class I MHC complexes.
J. Immunol. Methods, 464, 2019
1RT1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Esnouf, R., Hopkins, A., Willcox, B., Jones, Y., Ross, C., Stammers, D., Stuart, D.
Deposit date:1996-03-16
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
J.Med.Chem., 39, 1996
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