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5TIM
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REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
J.Mol.Biol., 220, 1991
3TIM
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THE CRYSTAL STRUCTURE OF THE "OPEN" AND THE "CLOSED" CONFORMATION OF THE FLEXIBLE LOOP OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K.
Deposit date:1990-05-15
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase.
Proteins, 10, 1991
1DUB
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2-ENOYL-COA HYDRATASE, DATA COLLECTED AT 100 K, PH 6.5
Descriptor:2-ENOYL-COA HYDRATASE, ACETOACETYL-COENZYME A
Authors:Wierenga, R.K., Engel, C.K.
Deposit date:1996-06-10
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket.
EMBO J., 15, 1996
1TRI
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THE CRYSTAL STRUCTURE OF AN ENGINEERED MONOMERIC TRIOSEPHOSPHATE ISOMERASE, MONOTIM: THE CORRECT MODELLING OF AN EIGHT-RESIDUE LOOP
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION
Authors:Wierenga, R.K.
Deposit date:1993-10-08
Release date:1994-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of an engineered monomeric triosephosphate isomerase, monoTIM: the correct modelling of an eight-residue loop.
Structure, 1, 1993
6HRV
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CRYSTAL STRUCTURE OF THE ZEBRAFISH PEROXISOMAL SCP2-THIOLASE (TYPE-1)
Descriptor:SCP2-thiolase (type-1), GLYCEROL, ACETATE ION
Authors:Wierenga, R.K., Kiema, T.R., Thapa, C.J.
Deposit date:2018-09-28
Release date:2019-01-02
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
6HSJ
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CRYSTAL STRUCTURE OF THE ZEBRAFISH PEROXISOMAL SCP2-THIOLASE (TYPE-1) IN COMPLEX WITH COA
Descriptor:SCP2-thiolase (type-1), ACETATE ION, GLYCEROL, ...
Authors:Wierenga, R.K., Kiema, T.R., Thapa, C.J.
Deposit date:2018-10-01
Release date:2019-01-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
6HSP
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CRYSTAL STRUCTURE OF THE ZEBRAFISH PEROXISOMAL SCP2-THIOLASE (TYPE-1) IN COMPLEX WITH COA AND OCTANOYL-COA
Descriptor:SCP2-thiolase (type-1), GLYCEROL, OCTANOYL-COENZYME A, ...
Authors:Wierenga, R.K., Kiema, T.R., Thapa, C.J.
Deposit date:2018-10-01
Release date:2019-01-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
4TIM
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CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCERIC ACID
Authors:Nobel, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
6TIM
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THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Noble, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1DKW
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CRYSTAL STRUCTURE OF TRIOSE-PHOSPHATE ISOMERASE WITH MODIFIED SUBSTRATE BINDING SITE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, TERTIARY-BUTYL ALCOHOL
Authors:Norledge, B.V., Lambeir, A.M., Abagyan, R.A., Rottman, A., Fernandez, A.M., Filimonov, V.V., Peter, M.G., Wierenga, R.K.
Deposit date:1999-12-08
Release date:2000-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Modeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (loop 8) of triosephosphate isomerase: toward a new substrate specificity.
Proteins, 42, 2001
3ZBG
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CRYSTAL STRUCTURE OF WILD-TYPE SCP2 THIOLASE FROM LEISHMANIA MEXICANA AT 1.85 A
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-09
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBK
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA: THE C123A MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE, CHLORIDE ION, ...
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBL
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA: THE C123S MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
3ZBN
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA. COMPLEX OF THE C123A MUTANT WITH COENZYME A.
Descriptor:3-KETOACYL-COA THIOLASE-LIKE PROTEIN, COENZYME A
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2012-11-11
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
4BI9
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CRYSTAL STRUCTURE OF WILD-TYPE SCP2 THIOLASE FROM TRYPANOSOMA BRUCEI.
Descriptor:3-KETOACYL-COA THIOLASE, PUTATIVE
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2013-04-10
Release date:2013-08-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
4BIA
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM TRYPANOSOMA BRUCEI: THE C337A MUTANT.
Descriptor:3-KETOACYL-COA THIOLASE, PUTATIVE
Authors:Harijan, R.K., Kiema, T.-R., Weiss, M.S., Michels, P.A.M., Wierenga, R.K.
Deposit date:2013-04-10
Release date:2013-08-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
4C2J
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-KETOACYL-COA THIOLASE IN COMPLEX WITH COA
Descriptor:3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, 1,2-ETHANEDIOL, ...
Authors:Kiema, T.-R., Harijan, R.K., Wierenga, R.K.
Deposit date:2013-08-19
Release date:2014-09-03
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities
Acta Crystallogr.,Sect.D, 70, 2014
4C2K
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-KETOACYL-COA THIOLASE
Descriptor:3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, 1,2-ETHANEDIOL, ...
Authors:Kiema, T.-R., Harijan, R.K., Wierenga, R.K.
Deposit date:2013-08-19
Release date:2014-09-03
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities
Acta Crystallogr.,Sect.D, 70, 2014
4EGV
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CRYSTAL STRUCTURE OF A MONOMERIC SCP2-THIOLASE LIKE PROTEIN TYPE 1 (STLP1) FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Acetyl-CoA acetyltransferase
Authors:Janardan, N., Harijan, R.K., Wierenga, R.K., Murthy, M.R.N.
Deposit date:2012-04-01
Release date:2012-09-12
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatis.
Plos One, 7, 2012
5AB4
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI SCP2-THIOLASE LIKE PROTEIN (TBSLP) FORM-I.
Descriptor:SCP2-THIOLASE LIKE PROTEIN
Authors:Harijan, R.K., Kiema, T.R., Wierenga, R.K.
Deposit date:2015-08-01
Release date:2016-05-04
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:The Scp2-Thiolase-Like Protein (Slp) of Trypanosoma Brucei is an Enzyme Involved in Lipid Metabolism.
Proteins, 84, 2016
5AB5
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI SCP2-THIOLASE LIKE PROTEIN (TBSLP) FORM-II.
Descriptor:SCP2-THIOLASE LIKE PROTEIN, SULFATE ION
Authors:Harijan, R.K., Kiema, T.R., Wierenga, R.K.
Deposit date:2015-08-01
Release date:2016-05-04
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Scp2-Thiolase-Like Protein (Slp) of Trypanosoma Brucei is an Enzyme Involved in Lipid Metabolism.
Proteins, 84, 2016
5AB6
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI SCP2-THIOLASE LIKE PROTEIN (TBSLP) IN COMPLEX WITH ACETOACETYL-COA.
Descriptor:SCP2-THIOLASE LIKE PROTEIN, ACETOACETYL-COENZYME A, SULFATE ION
Authors:Harijan, R.K., Kiema, T.R., Wierenga, R.K.
Deposit date:2015-08-01
Release date:2016-05-04
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Scp2-Thiolase-Like Protein (Slp) of Trypanosoma Brucei is an Enzyme Involved in Lipid Metabolism.
Proteins, 84, 2016
5AB7
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI SCP2-THIOLASE LIKE PROTEIN (TBSLP) IN COMPLEX WITH MALONYL-COA.
Descriptor:SCP2-THIOLASE LIKE PROTEIN, MALONYL-COENZYME A, SULFATE ION
Authors:Harijan, R.K., Kiema, T.R., Wierenga, R.K.
Deposit date:2015-08-02
Release date:2016-05-04
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Scp2-Thiolase-Like Protein (Slp) of Trypanosoma Brucei is an Enzyme Involved in Lipid Metabolism.
Proteins, 84, 2016
5BZ4
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CRYSTAL STRUCTURE OF A T1-LIKE THIOLASE (COA-COMPLEX) FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Beta-ketothiolase, COENZYME A
Authors:Janardan, N., Harijan, R.K., Kiema, T.R., Wierenga, R.K., Murthy, M.R.N.
Deposit date:2015-06-11
Release date:2016-05-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
Acta Crystallogr.,Sect.D, 71, 2015
5LNQ
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CRYSTAL STRUCTURE OF SCP2 THIOLASE FROM LEISHMANIA MEXICANA. COMPLEX OF THE C123A MUTANT WITH ACETOACETYL-COA.
Descriptor:3-ketoacyl-CoA thiolase-like protein, ACETOACETYL-COENZYME A
Authors:Harijan, R.K., Kiema, T.-R., Wierenga, R.K.
Deposit date:2016-08-06
Release date:2017-01-18
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.
Protein Eng. Des. Sel., 30, 2017