1C1G
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1AK5
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1FNT
| CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION | Descriptor: | MAGNESIUM ION, PROTEASOME ACTIVATOR PROTEIN PA26, PROTEASOME COMPONENT C1, ... | Authors: | Whitby, F.G, Masters, E, Kramer, L, Knowlton, J.R, Yao, Y, Wang, C.C, Hill, C.P. | Deposit date: | 2000-08-23 | Release date: | 2001-04-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the activation of 20S proteasomes by 11S regulators. Nature, 408, 2000
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1LC3
| Crystal Structure of a Biliverdin Reductase Enzyme-Cofactor Complex | Descriptor: | Biliverdin Reductase A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION | Authors: | Whitby, F.G, Phillips, J.D, Hill, C.P, McCoubrey, W, Maines, M.D. | Deposit date: | 2002-04-05 | Release date: | 2002-07-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. J.Mol.Biol., 319, 2002
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1LC0
| Structure of Biliverdin Reductase and the Enzyme-NADH Complex | Descriptor: | Biliverdin Reductase A, PHOSPHATE ION | Authors: | Whitby, F.G, Phillips, J.D, Hill, C.P, McCoubrey, W, Maines, M.D. | Deposit date: | 2002-04-04 | Release date: | 2002-07-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. J.Mol.Biol., 319, 2002
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1NDD
| STRUCTURE OF NEDD8 | Descriptor: | CHLORIDE ION, PROTEIN (UBIQUITIN-LIKE PROTEIN NEDD8), SULFATE ION | Authors: | Whitby, F.G, Xia, G, Pickart, C.M, Hill, C.P. | Deposit date: | 1998-08-21 | Release date: | 1999-02-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J.Biol.Chem., 273, 1998
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1URO
| UROPORPHYRINOGEN DECARBOXYLASE | Descriptor: | BETA-MERCAPTOETHANOL, PROTEIN (UROPORPHYRINOGEN DECARBOXYLASE) | Authors: | Whitby, F.G, Phillips, J.D, Kushner, J.P, Hill, C.P. | Deposit date: | 1998-08-21 | Release date: | 1998-08-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human uroporphyrinogen decarboxylase. EMBO J., 17, 1998
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7RCM
| Crystal Structure of ADP-bound Galactokinase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Galactokinase, ... | Authors: | Whitby, F.G. | Deposit date: | 2021-07-07 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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7RCL
| Crystal Structure of ADP-bound Galactokinase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Galactokinase, MAGNESIUM ION, ... | Authors: | Whitby, F.G, Hall, M.D. | Deposit date: | 2021-07-07 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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7S49
| Crystal Structure of Inhibitor-bound Galactokinase | Descriptor: | (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one, Galactokinase, PHOSPHATE ION, ... | Authors: | Whitby, F.G. | Deposit date: | 2021-09-08 | Release date: | 2021-09-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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7S4C
| Crystal Structure of Inhibitor-bound Galactokinase | Descriptor: | 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid, Galactokinase, PHOSPHATE ION, ... | Authors: | Whitby, F.G. | Deposit date: | 2021-09-08 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64, 2021
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5ILS
| Autoinhibited ETV1 | Descriptor: | ETS translocation variant 1 | Authors: | Whitby, F.G, Currie, S.L. | Deposit date: | 2016-03-04 | Release date: | 2017-02-22 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
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5ILV
| Uninhibited ETV5 | Descriptor: | ETS translocation variant 5 | Authors: | Whitby, F.G, Currie, S.L. | Deposit date: | 2016-03-04 | Release date: | 2017-02-22 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
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5ILU
| Autoinhibited ETV4 | Descriptor: | ETS translocation variant 4 | Authors: | Whitby, F.G, Currie, S.L. | Deposit date: | 2016-03-04 | Release date: | 2017-02-22 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
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8UC6
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4R0R
| Ebolavirus GP Prehairpin Intermediate Mimic | Descriptor: | eboIZN21 | Authors: | Clinton, T.R, Weinstock, M.T, Jacobsen, M.T, Szabo-Fresnais, N, Pandya, M.J, Whitby, F.G, Herbert, A.S, Prugar, L.I, McKinnon, R, Hill, C.P, Welch, B.D, Dye, J.M, Eckert, D.M, Kay, M.S. | Deposit date: | 2014-08-01 | Release date: | 2014-10-22 | Last modified: | 2015-04-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets. Protein Sci., 24, 2015
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4WLQ
| Crystal structure of mUCH37-hRPN13 CTD complex | Descriptor: | Proteasomal ubiquitin receptor ADRM1, Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Authors: | Hemmis, C.W, Hill, C.P, VanderLinden, R, Whitby, F.G. | Deposit date: | 2014-10-07 | Release date: | 2015-03-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. Mol.Cell, 57, 2015
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6E93
| Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 in complex with methylated DNA | Descriptor: | DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ... | Authors: | Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A. | Deposit date: | 2018-07-31 | Release date: | 2018-11-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38. J. Biol. Chem., 293, 2018
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6E94
| Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R in complex with methylated DNA | Descriptor: | DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ... | Authors: | Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A. | Deposit date: | 2018-07-31 | Release date: | 2018-11-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.594 Å) | Cite: | Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38. J. Biol. Chem., 293, 2018
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2HTH
| Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain | Descriptor: | Ubiquitin, Vacuolar protein sorting protein 36 | Authors: | Alam, S.L, Whitby, F.G, Hill, C.P, Sundquist, W.I. | Deposit date: | 2006-07-25 | Release date: | 2006-10-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat.Struct.Mol.Biol., 13, 2006
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3RBQ
| Co-crystal structure of human UNC119 (retina gene 4) and an N-terminal Transducin-alpha mimicking peptide | Descriptor: | Guanine nucleotide-binding protein G(t) subunit alpha-1, Protein unc-119 homolog A | Authors: | Constantine, R, Whitby, F.G, Hill, C.P, Baehr, W. | Deposit date: | 2011-03-29 | Release date: | 2011-06-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | UNC119 is required for G protein trafficking in sensory neurons. Nat.Neurosci., 14, 2011
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1Z7Q
| Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator PA26 from Trypanosome brucei at 3.2 angstroms resolution | Descriptor: | Potential proteasome component C5, Proteasome component C1, Proteasome component C11, ... | Authors: | Forster, A, Whitby, F.G, Hill, C.P. | Deposit date: | 2005-03-26 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol.Cell, 18, 2005
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6PSA
| PIE12 D-PEPTIDE AGAINST HIV ENTRY (IN COMPLEX WITH IQN17 Q577R RESISTANCE MUTANT) | Descriptor: | CHLORIDE ION, IQN17, PIE12 D-peptide | Authors: | Hill, C.P, Whitby, F.G, Kay, M, Weinstock, M. | Deposit date: | 2019-07-12 | Release date: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Characterization of resistance to a potent D-peptide HIV entry inhibitor. Retrovirology, 16, 2019
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4V7O
| Proteasome Activator Complex | Descriptor: | Proteasome activator BLM10, Proteasome component C1, Proteasome component C11, ... | Authors: | Hill, C.P, Whitby, F.G. | Deposit date: | 2009-12-22 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. Mol.Cell, 37, 2010
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4LCB
| Structure of Vps4 homolog from Acidianus hospitalis | Descriptor: | CHLORIDE ION, Cell division protein CdvC, Vps4 | Authors: | Han, H, Hill, C.P, Whitby, F.G, Monroe, N. | Deposit date: | 2013-06-21 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The Oligomeric State of the Active Vps4 AAA ATPase. J.Mol.Biol., 426, 2014
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