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8GHR
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BU of 8ghr by Molmil
Structure of human ENPP1 in complex with variable heavy domain VH27.2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ...
Authors:Carozza, J.A, Wang, H, Solomon, P.E, Wells, J.A, Li, L.
Deposit date:2023-03-10
Release date:2023-08-02
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Discovery of VH domains that allosterically inhibit ENPP1.
Nat.Chem.Biol., 20, 2024
1AXI
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BU of 1axi by Molmil
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
5IC6
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BU of 5ic6 by Molmil
Crystal structure of caspase-7 DEVE peptide complex
Descriptor: Caspase-7 subunit p11, Caspase-7 subunit p20, DEVE peptide
Authors:Seaman, J.E, Julien, O, Lee, P.S, Rettenmaier, T.J, Thomsen, N.D, Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
5IC4
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BU of 5ic4 by Molmil
Crystal structure of caspase-3 DEVE peptide complex
Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, DEVE peptide
Authors:Seaman, J.E, Julien, O, Lee, P.S, Rettenmaier, T.J, Thomsen, N.D, Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
6B8Z
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BU of 6b8z by Molmil
Multiconformer model of WT PTP1B with BB3 at 273 K
Descriptor: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6B90
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BU of 6b90 by Molmil
Multiconformer model of apo WT PTP1B with glycerol at 100 K (ALTERNATIVE REFINEMENT OF PDB 1SUG showing conformational heterogeneity)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6B8T
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BU of 6b8t by Molmil
Multiconformer model of apo WT PTP1B with glycerol at 240 K
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6B8X
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BU of 6b8x by Molmil
Multiconformer model of apo WT PTP1B with glycerol at 278 K
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6BAI
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BU of 6bai by Molmil
Multiconformer model of apo K197C PTP1B at 100 K
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-12
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6B8E
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BU of 6b8e by Molmil
Multiconformer model of apo WT PTP1B with glycerol at 180 K
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-06
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
6B95
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BU of 6b95 by Molmil
Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-(2',4'-difluoro-4-hydroxy[1,1'-biphenyl]-3-yl)-2-sulfanylacetamide, Tyrosine-protein phosphatase non-receptor type 1
Authors:Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S.
Deposit date:2017-10-10
Release date:2018-06-20
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018
4RQV
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BU of 4rqv by Molmil
Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RS2
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Rettenmaier, T.J, Wells, J.A.
Deposit date:2014-11-05
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Proc.Natl.Acad.Sci.USA, 111, 2014
4RQK
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BU of 4rqk by Molmil
Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RS1
Descriptor: 3-phosphoinositide-dependent protein kinase 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Rettenmaier, T.J, Wells, J.A.
Deposit date:2014-11-03
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Proc.Natl.Acad.Sci.USA, 111, 2014
4RRV
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BU of 4rrv by Molmil
Crystal structure of PDK1 in complex with ATP and PIFtide
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Rettenmaier, T.J, Wells, J.A.
Deposit date:2014-11-06
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.412 Å)
Cite:A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Proc.Natl.Acad.Sci.USA, 111, 2014
1SHJ
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BU of 1shj by Molmil
Caspase-7 in complex with DICA allosteric inhibitor
Descriptor: 2-(2,4-DICHLORO-PHENOXY)-N-(2-MERCAPTO-ETHYL)-ACETAMIDE, Caspase-7, SULFATE ION
Authors:Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A.
Deposit date:2004-02-25
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
1SHL
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BU of 1shl by Molmil
CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR
Descriptor: 5-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID-(2-MERCAPTO-ETHYL)-AMIDE, Caspase-7
Authors:Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A.
Deposit date:2004-02-25
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
4XX9
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BU of 4xx9 by Molmil
Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RF4
Descriptor: (2-{[2-(2,6-dimethylphenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Rettenmaier, T.J, Wells, J.A.
Deposit date:2015-01-29
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.
J.Med.Chem., 58, 2015
6DF1
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BU of 6df1 by Molmil
Anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with phosphotyrosine peptide
Descriptor: Anti-phosphotyrosine antibody 4G10-4D5 heavy chain, Anti-phosphotyrosine antibody 4G10-4D5 light chain, LEU-PTR
Authors:Mou, K, Leung, K, Wells, J.A.
Deposit date:2018-05-13
Release date:2018-11-28
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
J. Am. Chem. Soc., 140, 2018
6DF2
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BU of 6df2 by Molmil
Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide
Descriptor: Anti-phosphotyrosine antibody c310-4D5 heavy chain, Anti-phosphotyrosine antibody c310-4D5 light chain, LEU-PTR-LEU
Authors:Mou, K, Leung, K, Wells, J.A.
Deposit date:2018-05-13
Release date:2018-11-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
J. Am. Chem. Soc., 140, 2018
6DEZ
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BU of 6dez by Molmil
Anti-phosphotyrosine antibody PY20-4D5 Fab complexed with sulfate
Descriptor: Anti-phosphotyrosine antibody PY20-4D5 heavy chain, Anti-phosphotyrosine antibody PY20-4D5 light chain, SULFATE ION
Authors:Mou, K, Leung, K, Wells, J.A.
Deposit date:2018-05-13
Release date:2018-11-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
J. Am. Chem. Soc., 140, 2018
6DF0
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BU of 6df0 by Molmil
anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate
Descriptor: 4G10-4D5 Antibody Light chain, 4G10-4D5 Antibody heavy chain, SULFATE ION
Authors:Mou, K, Leung, K, Wells, J.A.
Deposit date:2018-05-13
Release date:2018-11-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
J. Am. Chem. Soc., 140, 2018
3ORZ
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BU of 3orz by Molmil
PDK1 mutant bound to allosteric disulfide fragment activator 2A2
Descriptor: 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, 3-phosphoinositide-dependent protein kinase 1, 4-[4-(3-chlorophenyl)piperazin-1-yl]-4-oxobutane-1-thiol
Authors:Sadowsky, J.D, Wells, J.A.
Deposit date:2010-09-08
Release date:2011-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9995 Å)
Cite:Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Proc.Natl.Acad.Sci.USA, 108, 2011
3ORX
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BU of 3orx by Molmil
PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8
Descriptor: 2-methyl-N-(2-sulfanylethyl)-1-benzofuran-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1, CHLORIDE ION
Authors:Sadowsky, J.D, Wells, J.A.
Deposit date:2010-09-08
Release date:2011-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2044 Å)
Cite:Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OTU
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BU of 3otu by Molmil
PDK1 mutant bound to allosteric disulfide fragment activator JS30
Descriptor: 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, 3-phosphoinositide-dependent protein kinase 1, 4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-4-oxobutane-1-thiol, ...
Authors:Sadowsky, J.D, Wells, J.A.
Deposit date:2010-09-13
Release date:2011-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1013 Å)
Cite:Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Proc.Natl.Acad.Sci.USA, 108, 2011
1DN2
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BU of 1dn2 by Molmil
FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2
Descriptor: ENGINEERED PEPTIDE, IMMUNOGLOBULIN LAMBDA HEAVY CHAIN, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:DeLano, W.L, Ultsch, M.H, de Vos, A.M, Wells, J.A.
Deposit date:1999-12-15
Release date:2000-05-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Convergent solutions to binding at a protein-protein interface.
Science, 287, 2000

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