Author results

3J5M
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CRYO-EM STRUCTURE OF THE BG505 SOSIP.664 HIV-1 ENV TRIMER WITH 3 PGV04 FABS
Descriptor:BG505 SOSIP gp120, BG505 SOSIP gp41, PGV04 light chain, ...
Authors:Lyumkis, D., Julien, J.-P., Wilson, I.A., Ward, A.B.
Deposit date:2013-10-26
Release date:2013-11-13
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
Science, 342, 2013
4NCO
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CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV-1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING FAB PGT122
Descriptor:BG505 SOSIP gp120, BG505 SOSIP gp41, PGT122 light chain, ...
Authors:Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A.
Deposit date:2013-10-24
Release date:2013-11-13
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Science, 342, 2013
4NHG
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CRYSTAL STRUCTURE OF 2G12 IGG DIMER
Descriptor:2G12 IgG dimer heavy chain, 2G12 IgG dimer light chain, Hepatitis B virus receptor binding protein
Authors:Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J.
Deposit date:2013-11-05
Release date:2014-02-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (8.001 Å)
Cite:Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12.
Cell Rep, 5, 2013
4NHH
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STRUCTURE OF 2G12 IGG DIMER
Descriptor:2G12 IgG dimer light chain, Hepatitis B virus receptor binding protein, 2G12 IgG dimer heavy chain
Authors:Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J.
Deposit date:2013-11-05
Release date:2014-02-26
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12.
Cell Rep, 5, 2013
5ACO
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CRYO-EM STRUCTURE OF PGT128 FAB IN COMPLEX WITH BG505 SOSIP.664 ENV TRIMER
Descriptor:HIV-1 ENVELOPE GLYCOPROTEIN, PGT128 FAB, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lee, J.H., Ward, A.B.
Deposit date:2015-08-17
Release date:2015-09-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy.
Structure, 23, 2015
5AWN
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CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 BROADLY NEUTRALIZING ANTIBODY 3BC176 FAB
Descriptor:Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab
Authors:Lee, J.H., Wilson, I.A., Ward, A.B.
Deposit date:2015-07-06
Release date:2015-11-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015
5CCK
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CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 BROADLY NEUTRALIZING ANTIBODY 3BC315 FAB
Descriptor:Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID
Authors:Lee, J.H., Ward, A.B., Wilson, I.A.
Deposit date:2015-07-02
Release date:2015-10-07
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015
5FUU
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ECTODOMAIN OF CLEAVED WILD TYPE JR-FL ENVDCT TRIMER IN COMPLEX WITH PGT151 FAB
Descriptor:HIV-1 ENVELOPE GLYCOPROTEIN GP160, IMMUNOGLOBULIN G PGT151, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lee, J.H., Ward, A.B.
Deposit date:2016-01-29
Release date:2016-03-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-Em Structure of a Native, Fully Glycosylated and Cleaved HIV-1 Envelope Trimer
Science, 351, 2016
5I08
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PREFUSION STRUCTURE OF A HUMAN CORONAVIRUS SPIKE PROTEIN
Descriptor:Spike glycoprotein, envelope glycoprotein chimera
Authors:Kirchdoerfer, R.N., Cottrell, C.A., Wang, N., Pallesen, J., Yassine, H.M., Turner, H.L., Corbett, K.S., Graham, B.S., McLellan, J.S., Ward, A.B.
Deposit date:2016-02-03
Release date:2016-03-02
Last modified:2016-04-13
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Pre-fusion structure of a human coronavirus spike protein.
Nature, 531, 2016
5KEL
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEM
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EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91
Descriptor:BDBV91 variable Fab domain light chain, BDBV91 variable Fab domain heavy chain, c13C6 variable Fab domain heavy chain, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEN
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5V8L
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BG505 SOSIP.664 TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING HIV ANTIBODIES 3BNC117 AND PGT145
Descriptor:gp120, gp41, 3BNC117 antibody, ...
Authors:Lee, J.H., Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5V8M
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BG505 SOSIP.664 TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING HIV ANTIBODY 3BNC117
Descriptor:gp120, gp41, antibody 3BNC117, ...
Authors:Lee, J.H., Cottrell, C.A., Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2017-07-26
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5VN3
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CRYO-EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH SOLUBLE CD4 (D1-D2) AND FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF 17B
Descriptor:17b Fab light chain, Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, ...
Authors:Ozorowski, G., Pallesen, J., Ward, A.B.
Deposit date:2017-04-28
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature, 547, 2017
5VN8
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CRYO-EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF B12
Descriptor:Envelope glycoprotein gp160, b12 Fab heavy chain, b12 Fab light chain, ...
Authors:Ozorowski, G., Pallesen, J., Ward, A.B., Cottrell, C.A.
Deposit date:2017-04-28
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature, 547, 2017
5VYH
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CRYSTAL STRUCTURE OF MERS-COV S1 N-TERMINAL DOMAIN
Descriptor:S protein, N-ACETYL-D-GLUCOSAMINE, FOLIC ACID, ...
Authors:Wang, N., Wrapp, D., Pallesen, J., Ward, A.B., McLellan, J.S.
Deposit date:2017-05-25
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9H
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:MERS S, G4 VH, G4 VL, ...
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9I
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL, ...
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9J
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9K
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9L
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9M
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9N
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:MERS S, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W9O
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MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4
Descriptor:Spike glycoprotein, G4 VH, G4 VL
Authors:Pallesen, J., Ward, A.B.
Deposit date:2017-06-23
Release date:2017-08-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017