Author results

6JFH
  • Download 6jfh
  • View 6jfh
Molmil generated image of 6jfh
THE ASYMMETRIC-RECONSTRUCTED CRYO-EM STRUCTURE OF ZIKA VIRUS-FABZK2B10 COMPLEX
Descriptor:ZIKV structural E protein, strutural protein M, FabZK2B10 heavy chain, ...
Authors:Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q.
Deposit date:2019-02-08
Release date:2019-04-10
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
6JFI
  • Download 6jfi
  • View 6jfi
Molmil generated image of 6jfi
THE SYMMETRIC-RECONSTRUCTED CRYO-EM STRUCTURE OF ZIKA VIRUS-FABZK2B10 COMPLEX
Descriptor:ZIKV structural protein E, strutural protein M, FabZK2B10 heavy chain, ...
Authors:Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q.
Deposit date:2019-02-08
Release date:2019-04-10
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
6A85
  • Download 6a85
  • View 6a85
Molmil generated image of 6a85
CRYSTAL STRUCTURE OF A NOVEL DNA QUADRUPLEX
Descriptor:DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*GP*GP*GP*TP*GP*CP*GP*TP*T)-3'), LITHIUM ION, SODIUM ION, ...
Authors:Liu, H.H., Gan, J.H.
Deposit date:2018-07-06
Release date:2019-03-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads.
Nucleic Acids Res., 46, 2018
6D8L
  • Download 6d8l
  • View 6d8l
Molmil generated image of 6d8l
GROUP I SELF-SPLICING INTRON P4-P6 DOMAIN MUTANT U131A (WITHOUT ISOPROPANOL SOAKING)
Descriptor:Group I self-splicing intron, MAGNESIUM ION
Authors:Shoffner, G.M.
Deposit date:2018-04-26
Release date:2018-07-18
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.140215 Å)
Cite:In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure, 26, 2018
6D8M
  • Download 6d8m
  • View 6d8m
Molmil generated image of 6d8m
GROUP I SELF-SPLICING INTRON P4-P6 DOMAIN MUTANT A125U/G126U
Descriptor:Group I self-splicing intron, MAGNESIUM ION
Authors:Shoffner, G.M.
Deposit date:2018-04-26
Release date:2018-07-04
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure, 26, 2018
6D8N
  • Download 6d8n
  • View 6d8n
Molmil generated image of 6d8n
GROUP I SELF-SPLICING INTRON P4-P6 DOMAIN MUTANT G134A/U185AA
Descriptor:Group I self-splicing intron, MAGNESIUM ION
Authors:Shoffner, G.M.
Deposit date:2018-04-26
Release date:2018-07-18
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.954271 Å)
Cite:In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure, 26, 2018
6D8O
  • Download 6d8o
  • View 6d8o
Molmil generated image of 6d8o
GROUP I SELF-SPLICING INTRON P4-P6 DOMAIN MUTANT A230U
Descriptor:Group I self-splicing intron, MAGNESIUM ION
Authors:Shoffner, G.M.
Deposit date:2018-04-26
Release date:2018-07-04
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.801125 Å)
Cite:In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure, 26, 2018
6C6N
  • Download 6c6n
  • View 6c6n
Molmil generated image of 6c6n
HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD AND CMPD-4"
Descriptor:Squalene monooxygenase, GLYCEROL, SULFATE ION, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
6C6P
  • Download 6c6p
  • View 6c6p
Molmil generated image of 6c6p
HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD AND NB-598
Descriptor:Squalene monooxygenase, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, (2E)-N-({3-[([3,3'-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
6C6R
  • Download 6c6r
  • View 6c6r
Molmil generated image of 6c6r
HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD
Descriptor:Squalene monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
5Z0S
  • Download 5z0s
  • View 5z0s
Molmil generated image of 5z0s
CRYSTAL STRUCTURE OF FGFR1 KINASE DOMAIN IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Fibroblast growth factor receptor 1, 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine
Authors:Liu, Q., Xu, Y.
Deposit date:2017-12-20
Release date:2018-12-26
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors
Molecules, 23, 2018
5YVE
  • Download 5yve
  • View 5yve
Molmil generated image of 5yve
CRYSTAL STRUCTURE OF HUMAN P2X3 RECEPTOR IN COMPLEX WITH THE AF-219 NEGATIVE ALLOSTERIC MODULATOR
Descriptor:P2X purinoceptor 3, MAGNESIUM ION, SODIUM ION, ...
Authors:Wang, Y., Hattori, M.
Deposit date:2017-11-25
Release date:2018-04-04
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Druggable negative allosteric site of P2X3 receptors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YR0
  • Download 5yr0
  • View 5yr0
Molmil generated image of 5yr0
STRUCTURE OF BECLIN1-UVRAG COILED COIL DOMAIN COMPLEX
Descriptor:Beclin-1, UV radiation resistance associated protein
Authors:Pan, X., Zhao, Y., He, Y.
Deposit date:2017-11-08
Release date:2018-06-13
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BJX
  • Download 6bjx
  • View 6bjx
Molmil generated image of 6bjx
GROUP I SELF-SPLICING INTRON P4-P6 DOMAIN MUTANT U131A (WITH ISOPROPANOL SOAKING)
Descriptor:Group I self-splicing intron P4-P6 domain, MAGNESIUM ION
Authors:Shoffner, G.M.
Deposit date:2017-11-07
Release date:2018-07-04
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure, 26, 2018
5Y38
  • Download 5y38
  • View 5y38
Molmil generated image of 5y38
CRYSTAL STRUCTURE OF C7ORF59-HBXIP COMPLEX
Descriptor:Ragulator complex protein LAMTOR5, Ragulator complex protein LAMTOR4, SULFATE ION
Authors:Zhang, T., Ding, J.
Deposit date:2017-07-28
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
5Y39
  • Download 5y39
  • View 5y39
Molmil generated image of 5y39
CRYSTAL STRUCTURE OF RAGULATOR COMPLEX (P18 76-145)
Descriptor:Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Zhang, T., Ding, J.
Deposit date:2017-07-28
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
5Y3A
  • Download 5y3a
  • View 5y3a
Molmil generated image of 5y3a
CRYSTAL STRUCTURE OF RAGULATOR COMPLEX (P18 49-161)
Descriptor:Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Zhang, T., Ding, J.
Deposit date:2017-07-28
Release date:2017-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
Nat Commun, 8, 2017
5WCU
  • Download 5wcu
  • View 5wcu
Molmil generated image of 5wcu
CRYSTAL STRUCTURE OF 167 BP NUCLEOSOME BOUND TO THE GLOBULAR DOMAIN OF LINKER HISTONE H5
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Jiang, J.S., Zhou, B.R.
Deposit date:2017-07-02
Release date:2018-10-31
Method:X-RAY DIFFRACTION (5.53 Å)
Cite:Revisit of Reconstituted 30-nm Nucleosome Arrays Reveals an Ensemble of Dynamic Structures.
J. Mol. Biol., 430, 2018
5XVA
  • Download 5xva
  • View 5xva
Molmil generated image of 5xva
CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH216
Descriptor:Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone, ETHANOL
Authors:Zhao, F., Li, H.
Deposit date:2017-06-27
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.847 Å)
Cite:Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
5XVF
  • Download 5xvf
  • View 5xvf
Molmil generated image of 5xvf
CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH062
Descriptor:Serine/threonine-protein kinase PAK 4, 2-(4-azanylpiperidin-1-yl)-6-chloranyl-N-(1-methylimidazol-4-yl)quinazolin-4-amine
Authors:Zhao, F., Li, H.
Deposit date:2017-06-27
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.655 Å)
Cite:Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
5XVG
  • Download 5xvg
  • View 5xvg
Molmil generated image of 5xvg
CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH226
Descriptor:Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone, ETHANOL, ...
Authors:Zhao, F., Li, H.
Deposit date:2017-06-27
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
5XP6
  • Download 5xp6
  • View 5xp6
Molmil generated image of 5xp6
NATIVE STRUCTURE OF NDM-1 CRYSTALLIZED AT PH5.5
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
Authors:Zhang, H., Ma, G., Lai, J., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
5XP9
  • Download 5xp9
  • View 5xp9
Molmil generated image of 5xp9
CRYSTAL STRUCTURE OF BISMUTH BOUND NDM-1
Descriptor:Metallo-beta-lactamase type 2, Bismuth(III) ION, GLYCEROL
Authors:Zhang, H., Ma, G., Lai, T.P., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
5XM8
  • Download 5xm8
  • View 5xm8
Molmil generated image of 5xm8
CRYSTAL STRUCTURE OF ASFVPOLX IN COMPLEX WITH DNA ENZYME AND PB.
Descriptor:Repair DNA polymerase X, DNA (36-MER), DNA (23-mer), ...
Authors:Liu, H.H., Gan, J.H.
Deposit date:2017-05-13
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of an RNA-cleaving DNAzyme.
Nat Commun, 8, 2017
5XM9
  • Download 5xm9
  • View 5xm9
Molmil generated image of 5xm9
CRYSTAL STRUCTURE OF ASFVPOLX IN COMPLEX WITH DNA ENZYME.
Descriptor:Repair DNA polymerase X, DNA (36-MER), DNA (23-mer)
Authors:Liu, H.H., Gan, J.H.
Deposit date:2017-05-13
Release date:2018-01-24
Method:X-RAY DIFFRACTION (3.053 Å)
Cite:Crystal structure of an RNA-cleaving DNAzyme.
Nat Commun, 8, 2017