Author results

4K47
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STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE LEUCYL-TRNA SYNTHETASE EDITING DOMAIN BOUND TO A BENZOXABOROLE-AMP ADDUCT
Descriptor:Leucine--tRNA ligase, [(1R,5R,6R,8S)-6-(6-aminopurin-9-yl)-3'-[(R)-oxidanyl(phenyl)methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1,3,5-triene]-8-yl]methyl dihydrogen phosphate, SULFATE ION
Authors:Hu, Q.H., Liu, R.J., Fang, Z.P., Zhang, J., Ding, Y.Y., Tan, M., Wang, M., Pan, W., Zhou, H.C., Wang, E.D.
Deposit date:2013-04-12
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Sci Rep, 3, 2013
4K48
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STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE LEUCYL-TRNA SYNTHETASE EDITING DOMAIN
Descriptor:Leucine--tRNA ligase
Authors:Hu, Q.H., Liu, R.J., Fang, Z.P., Zhang, J., Ding, Y.Y., Tan, M., Wang, M., Pan, W., Zhou, H.C., Wang, E.D.
Deposit date:2013-04-12
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Sci Rep, 3, 2013
4JAK
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CRYSTAL STRUCTURE OF TRNA (UM34/CM34) METHYLTRANSFERASE TRML FROM ESCHERICHIA COLI
Descriptor:tRNA (cytidine(34)-2'-O)-methyltransferase
Authors:Liu, R.J., Zhou, M., Wang, E.D.
Deposit date:2013-02-18
Release date:2013-07-31
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
Nucleic Acids Res., 41, 2013
4JAL
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CRYSTAL STRUCTURE OF TRNA (UM34/CM34) METHYLTRANSFERASE TRML FROM ESCHERICHIA COLI WITH SAH
Descriptor:tRNA (cytidine(34)-2'-O)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Liu, R.J., Zhou, M., Wang, E.D.
Deposit date:2013-02-18
Release date:2013-07-31
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
Nucleic Acids Res., 41, 2013
2AJG
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE
Descriptor:Leucyl-tRNA synthetase
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-01
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2AJH
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE COMPLEXES WITH METHIONINE
Descriptor:Leucyl-tRNA synthetase, METHIONINE
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-02
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
2AJI
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CRYSTAL STRUCTURE OF THE EDITING DOMAIN OF E. COLI LEUCYL-TRNA SYNTHETASE COMPLEXES WITH ISOLEUCINE
Descriptor:Leucyl-tRNA synthetase, ISOLEUCINE
Authors:Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Deposit date:2005-08-02
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Biochem.J., 394, 2006
3PZ0
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THE CRYSTAL STRUCTURE OF AALEURS-CP1
Descriptor:Leucyl-tRNA synthetase subunit alpha, CALCIUM ION
Authors:Liu, R.J., Wang, E.D.
Deposit date:2010-12-13
Release date:2011-08-24
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
3PZ5
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THE CRYSTAL STRUCTURE OF AALEURS-CP1-D20
Descriptor:Leucyl-tRNA synthetase subunit alpha
Authors:Liu, R.J., Wang, E.D.
Deposit date:2010-12-14
Release date:2011-08-24
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
3PZ6
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THE CRYSTAL STRUCTURE OF GLLEURS-CP1
Descriptor:Leucyl-tRNA synthetase
Authors:Liu, R.J., Du, D.H., Wang, E.D.
Deposit date:2010-12-14
Release date:2011-08-24
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
4XBO
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CRYSTAL STRUCTURE OF FULL LENGTH E.COLI TRMJ IN COMPLEX WITH SAH
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Liu, R.J., Long, T., Zhou, M., Wang, E.D.
Deposit date:2014-12-17
Release date:2015-12-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily
Nucleic Acids Res., 43, 2015
5B63
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CRYSTAL STRUCTURES OF E.COLI ARGINYL-TRNA SYNTHETASE (ARGRS) IN COMPLEX WITH SUBSTRATE TRNA(ARG)
Descriptor:Arginine--tRNA ligase, tRNA-Arg
Authors:Zhou, M., Ye, S., Stephen, P., Zhang, R., Wang, E.D., Giege, R., Lin, S.X.
Deposit date:2016-05-24
Release date:2017-05-31
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of E.coli arginyl-tRNA synthetase (ArgRS) in complex with substrate tRNA(Arg)
To Be Published
5WWQ
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CRYSTAL STRUCTURE OF HUMAN NSUN6
Descriptor:Putative methyltransferase NSUN6
Authors:Liu, R.J., Long, T., Wang, E.D.
Deposit date:2017-01-04
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.815 Å)
Cite:Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWR
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CRYSTAL STRUCTURE OF HUMAN NSUN6/TRNA/SFG
Descriptor:Putative methyltransferase NSUN6, tRNA, SINEFUNGIN
Authors:Liu, R.J., Long, T., Wang, E.D.
Deposit date:2017-01-04
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.096 Å)
Cite:Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWS
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CRYSTAL STRUCTURE OF HUMAN NSUN6/TRNA/SAM
Descriptor:tRNA, Putative methyltransferase NSUN6, S-ADENOSYLMETHIONINE
Authors:Liu, R.J., Long, T., Wang, E.D.
Deposit date:2017-01-04
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.247 Å)
Cite:Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWT
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CRYSTAL STRUCTURE OF HUMAN NSUN6/TRNA
Descriptor:Putative methyltransferase NSUN6, tRNA
Authors:Liu, R.J., Long, T., Wang, E.D.
Deposit date:2017-01-04
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5YYM
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CRYSTAL STRUCTURES OF E.COLI ARGINYL-TRNA SYNTHETASE (ARGRS) IN COMPLEX WITH SUBSTRATE ARG
Descriptor:Arginine--tRNA ligase, ARGININE
Authors:Zhou, M., Ye, S., Stephen, P., Zhang, R.G., Wang, E.D., Giege, R., Lin, S.X.
Deposit date:2017-12-10
Release date:2018-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures Of E.Coli Arginyl-Trna Synthetase (Argrs) In Complex With Substrates
To Be Published
5YYN
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CRYSTAL STRUCTURES OF E.COLI ARGINYL-TRNA SYNTHETASE (ARGRS) IN COMPLEX WITH SUBSTRATE TRNA(ARG)
Descriptor:Arginine--tRNA ligase, TRNA
Authors:Zhou, M., Ye, S., Stephen, P., Zhang, R.G., Wang, E.D., Giege, R., Lin, S.X.
Deposit date:2017-12-10
Release date:2018-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures Of E.Coli Arginyl-Trna Synthetase (Argrs) In Complex With Substrates
To Be Published
5ZVD
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII
Descriptor:389aa long hypothetical nucleolar protein
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVE
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SAH
Descriptor:389aa long hypothetical nucleolar protein, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.178 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVG
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SAM
Descriptor:389aa long hypothetical nucleolar protein, S-ADENOSYLMETHIONINE
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVH
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SFG
Descriptor:389aa long hypothetical nucleolar protein, SINEFUNGIN
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5FOG
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CRYSTAL STRUCTURE OF HTE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF NORVALINE (NV2AA)
Descriptor:LEUCYL-TRNA SYNTHETASE, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 1,2-ETHANEDIOL, ...
Authors:Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
Deposit date:2015-11-20
Release date:2016-08-03
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOL
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF ISOEUCINE (ILE2AA)
Descriptor:LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION, 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE
Authors:Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
Deposit date:2015-11-24
Release date:2016-08-03
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOM
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH THE ADDUCT AMP-AN6426
Descriptor:LEUCYL-TRNA SYNTHETASE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, PHOSPHATE ION
Authors:Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
Deposit date:2015-11-24
Release date:2016-08-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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