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1HG3
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BU of 1hg3 by Molmil
Crystal structure of tetrameric TIM from Pyrococcus woesei.
Descriptor: 3-PHOSPHONOPROPANOIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Walden, H, Bell, G.S, Russell, R.J.M, Siebers, B, Hensel, R, Taylor, G.L.
Deposit date:2000-12-12
Release date:2001-03-07
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Tiny Tim: A Small, Tetrameric, Hyperthermostable Triosephosphate Isomerase
J.Mol.Biol., 306, 2001
1R4N
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BU of 1r4n by Molmil
APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ubiquitin-like protein NEDD8, ZINC ION, ...
Authors:Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1R4M
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BU of 1r4m by Molmil
APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex
Descriptor: Ubiquitin-like protein NEDD8, ZINC ION, amyloid beta precursor protein-binding protein 1, ...
Authors:Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1W0M
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BU of 1w0m by Molmil
Triosephosphate isomerase from Thermoproteus tenax
Descriptor: PHOSPHATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Walden, H, Taylor, G, Lorentzen, E, Pohl, E, Lilie, H, Schramm, A, Knura, T, Stubbe, K, Tjaden, B, Hensel, R.
Deposit date:2004-06-08
Release date:2004-09-09
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Function of a Regulated Archaeal Triosephosphate Isomerase Adapted to High Temperature
J.Mol.Biol., 342, 2004
1YOV
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BU of 1yov by Molmil
Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
Descriptor: Amyloid protein-binding protein 1, Ubiquitin-activating enzyme E1C, ZINC ION
Authors:Walden, H, Podgorski, M.S, Schulman, B.A.
Deposit date:2005-01-28
Release date:2005-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
Nature, 422, 2003
7ZH3
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BU of 7zh3 by Molmil
USP1 bound to ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ZINC ION
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-04-05
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
7ZH4
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BU of 7zh4 by Molmil
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-04-05
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
7ZF1
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BU of 7zf1 by Molmil
Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H.
Deposit date:2022-03-31
Release date:2022-11-16
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
Embo J., 42, 2023
8A9J
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BU of 8a9j by Molmil
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323 (consensus reconstruction)
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-06-28
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
8A9K
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BU of 8a9k by Molmil
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-06-28
Release date:2022-10-12
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
6N13
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BU of 6n13 by Molmil
UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin
Descriptor: E3 ubiquitin-protein ligase parkin, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ...
Authors:Condos, T.E.C, Dunkerley, K.M, Freeman, E.A, Barber, K.R, Aguirre, J.D, Chaugule, V.K, Xiao, Y, Konermann, L, Walden, H, Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2020-01-08
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
5OJJ
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BU of 5ojj by Molmil
Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Ubiquitin-conjugating enzyme E2 T, ...
Authors:Morreale, F.E, Testa, A, Chaugule, V.K, Bortoluzzi, A, Ciulli, A, Walden, H.
Deposit date:2017-07-21
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
J. Med. Chem., 60, 2017
7AY0
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BU of 7ay0 by Molmil
Crystal structure of truncated USP1-UAF1
Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ZINC ION
Authors:Arkinson, C, Rennie, M.L, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY2
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BU of 7ay2 by Molmil
Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ...
Authors:Arkinson, C, Rennie, M.L, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY1
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BU of 7ay1 by Molmil
Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Arkinson, C, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
6R75
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BU of 6r75 by Molmil
Crystal structure of human Ube2T E54R mutant
Descriptor: Ubiquitin-conjugating enzyme E2 T
Authors:Chaugule, V.K, Rennie, M.L, Walden, H, Arkinson, C, Kamarainen, O, Toth, R.
Deposit date:2019-03-28
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric mechanism for site-specific ubiquitination of FANCD2.
Nat.Chem.Biol., 16, 2020
5NGZ
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BU of 5ngz by Molmil
Ube2T in complex with fragment EM04
Descriptor: 1-(1,3-benzothiazol-2-yl)methanamine, Ubiquitin-conjugating enzyme E2 T
Authors:Morreale, F.E, Bortoluzzi, A, Chaugule, V.K, Arkinson, C, Walden, H, Ciulli, A.
Deposit date:2017-03-21
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
5N2W
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BU of 5n2w by Molmil
WT-Parkin and pUB complex
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ...
Authors:Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
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BU of 5n38 by Molmil
S65DParkin and pUB complex
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, ...
Authors:Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5C23
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BU of 5c23 by Molmil
Parkin (S65DUblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:Kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C1Z
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BU of 5c1z by Molmil
Parkin (UblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
4CCG
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BU of 4ccg by Molmil
Structure of an E2-E3 complex
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CHLORIDE ION, ...
Authors:Hodson, C, Purkiss, A, Walden, H.
Deposit date:2013-10-22
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Human Fancl Ring-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection.
Structure, 22, 2014
1W3T
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BU of 1w3t by Molmil
Sulfolobus solfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with D-KDGal, D-Glyceraldehyde and pyruvate
Descriptor: 2-KETO-3-DEOXY GLUCONATE ALDOLASE, 3-DEOXY-D-LYXO-HEXONIC ACID, D-Glyceraldehyde, ...
Authors:Theodossis, A, Walden, H, Westwick, E.J, Connaris, H, Lamble, H.J, Hough, D.W, Danson, M.J, Taylor, G.L.
Deposit date:2004-07-19
Release date:2004-09-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
J. Biol. Chem., 279, 2004
1W37
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BU of 1w37 by Molmil
2-keto-3-deoxygluconate(KDG) aldolase of Sulfolobus solfataricus
Descriptor: 2-KETO-3-DEOXY GLUCONATE ALDOLASE, GLYCEROL, SODIUM ION
Authors:Theodossis, A, Walden, H, Westwick, E.J, Connaris, H, Lamble, H.J, Hough, D.W, Danson, M.J, Taylor, G.L.
Deposit date:2004-07-13
Release date:2004-09-02
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
J. Biol. Chem., 279, 2004
1W3N
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BU of 1w3n by Molmil
Sulfolobus solfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with D-KDG
Descriptor: 2-KETO-3-DEOXY GLUCONATE ALDOLASE, 3-DEOXY-D-ARABINO-HEXONIC ACID, GLYCEROL
Authors:Theodossis, A, Walden, H, Westwick, E.J, Connaris, H, Lamble, H.J, Hough, D.W, Danson, M.J, Taylor, G.L.
Deposit date:2004-07-17
Release date:2004-09-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
J. Biol. Chem., 279, 2004

 

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